PMID- 2695468
OWN - NLM
STAT- MEDLINE
DCOM- 19900323
LR  - 20190816
IS  - 0167-5273 (Print)
IS  - 0167-5273 (Linking)
VI  - 25 Suppl 1
DP  - 1989
TI  - Pathogenetic mechanisms in essential hypertension. Analogies between a rat model 
      and the human disease.
PG  - S29-36
AB  - Essential hypertension is a genetic disease. Its phenotypic expression depends on 
      the interaction between genetic and environmental factors. In prehypertensive 
      rats of the Milan hypertensive strain (MHS) a genetically inherited increase of 
      tubular reabsorption was found, which causes the increase of blood pressure. 
      Studies of ion transport systems in these rats have shown that the Na-K 
      cotransport activity is increased both in erythrocytes and in tubular cells of 
      MHS rats compared with their normotensive controls (MNS) and that this alteration 
      is genetically linked to the transmission of high blood pressure levels. Also, in 
      young human normotensives prone to develop essential hypertension there is an 
      abnormal pattern of renal function which could be in agreement with a primitive 
      increase in tubular reabsorption. Studies of erythrocyte ion transport systems in 
      these subjects suggest that at least in a subgroup of humans predisposed to 
      develop essential hypertension a pathogenetic mechanism similar to the one 
      proposed for the MHS rat can be at work.
FAU - Cusi, D
AU  - Cusi D
AD  - Institute of Medical Sciences, Postgraduate School of Nephrology, University of 
      Milano, Italy.
FAU - Alberghini, E
AU  - Alberghini E
FAU - Pati, P
AU  - Pati P
FAU - Tripodi, G
AU  - Tripodi G
FAU - Barlassina, C
AU  - Barlassina C
FAU - Colombo, R
AU  - Colombo R
FAU - Cova, T
AU  - Cova T
FAU - Niutta, E
AU  - Niutta E
FAU - Vezzoli, G
AU  - Vezzoli G
FAU - Bianchi, G
AU  - Bianchi G
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - Netherlands
TA  - Int J Cardiol
JT  - International journal of cardiology
JID - 8200291
SB  - IM
MH  - Animals
MH  - Disease Models, Animal
MH  - Humans
MH  - Hypertension/*physiopathology
MH  - Rats
MH  - Species Specificity
RF  - 29
EDAT- 1989/01/01 00:00
MHDA- 1989/01/01 00:01
CRDT- 1989/01/01 00:00
PHST- 1989/01/01 00:00 [pubmed]
PHST- 1989/01/01 00:01 [medline]
PHST- 1989/01/01 00:00 [entrez]
AID - 0167-5273(89)90090-9 [pii]
AID - 10.1016/0167-5273(89)90090-9 [doi]
PST - ppublish
SO  - Int J Cardiol. 1989;25 Suppl 1:S29-36. doi: 10.1016/0167-5273(89)90090-9.