PMID- 26955325
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20160309
LR  - 20200929
IS  - 1662-4548 (Print)
IS  - 1662-453X (Electronic)
IS  - 1662-453X (Linking)
VI  - 10
DP  - 2016
TI  - Sexual Behavior Increases Cell Proliferation in the Rostral Migratory Stream and 
      Promotes the Differentiation of the New Cells into Neurons in the Accessory 
      Olfactory Bulb of Female Rats.
PG  - 48
LID - 10.3389/fnins.2016.00048 [doi]
LID - 48
AB  - We have previously demonstrated, that 15 days after female rats pace the sexual 
      interaction, there is an increase in the number of new cells that reach the 
      granular cell layer (GrL) of the accessory olfactory bulb (AOB). The aim of the 
      present study was to evaluate, if the first sexual experience in the female rat 
      increases cell proliferation in the subventricular zone (SVZ) and the rostral 
      migratory stream (RMS). We also tested if this behavior promotes the survival of 
      the new cells that integrate into the main olfactory bulb (MOB) and AOB 45 days 
      after the behavioral test. Sexually, naive female rats were injected with the DNA 
      synthesis marker 5'-bromo-2'-deoxyuridine (BrdU) on the day of the behavioral 
      test. They were randomly divided into the following groups: Female rats placed 
      alone in the mating cage (1); Females exposed to amyl acetate odor [banana scent, 
      (2)]; Females that could see, hear, and smell the male but physical contact was 
      not possible [exposed to male, (3)]; Female rats that could pace the sexual 
      interaction (4); and females that mated without the possibility of pacing the 
      sexual interaction (5). Animals were sacrificed 2 days after the behavioral test 
      (proliferation) or 45 days later (survival). Our results show that 2 days after 
      females were exposed to banana scent or to the male, they had a higher number of 
      cells in the SVZ. Females, that mated in pace and no-paced conditions had more 
      new cells in the RMS. At 45 days, no significant differences were found in the 
      number of new cells that survived in the MOB or in the AOB. However, mating 
      increased the percentage of new cells, that differentiated into neurons in the 
      GrL of the AOB. These new cells expressed c-Fos after a second sexual encounter 
      just before the females were sacrificed. No significant differences in plasma 
      levels of estradiol and progesterone were observed between groups. Our results 
      indicate that the first sexual experience increases cell proliferation in the RMS 
      and mating 45 days later enhances the number of new cells that differentiate into 
      neurons in the AOB. These new neurons are activated by sexual stimulation.
FAU - Corona, Rebeca
AU  - Corona R
AD  - Instituto de Neurobiologia, Universidad Nacional Autonoma de Mexico Mexico, 
      Mexico.
FAU - Retana-Marquez, Socorro
AU  - Retana-Marquez S
AD  - Departamento de Biologia de la Reproduccion, Universidad Autonoma 
      Metropolitana-Iztapalapa Mexico, Mexico.
FAU - Portillo, Wendy
AU  - Portillo W
AD  - Instituto de Neurobiologia, Universidad Nacional Autonoma de Mexico Mexico, 
      Mexico.
FAU - Paredes, Raul G
AU  - Paredes RG
AD  - Instituto de Neurobiologia, Universidad Nacional Autonoma de Mexico Mexico, 
      Mexico.
LA  - eng
PT  - Journal Article
DEP - 20160226
PL  - Switzerland
TA  - Front Neurosci
JT  - Frontiers in neuroscience
JID - 101478481
PMC - PMC4767934
OTO - NOTNLM
OT  - cell proliferation
OT  - cell survival
OT  - neurogenesis and sexual behavior
OT  - olfactory bulbs
OT  - paced mating
EDAT- 2016/03/10 06:00
MHDA- 2016/03/10 06:01
PMCR- 2016/01/01
CRDT- 2016/03/09 06:00
PHST- 2015/12/15 00:00 [received]
PHST- 2016/02/03 00:00 [accepted]
PHST- 2016/03/09 06:00 [entrez]
PHST- 2016/03/10 06:00 [pubmed]
PHST- 2016/03/10 06:01 [medline]
PHST- 2016/01/01 00:00 [pmc-release]
AID - 10.3389/fnins.2016.00048 [doi]
PST - epublish
SO  - Front Neurosci. 2016 Feb 26;10:48. doi: 10.3389/fnins.2016.00048. eCollection 
      2016.