PMID- 26956025 OWN - NLM STAT- MEDLINE DCOM- 20161020 LR - 20220318 IS - 1475-2891 (Electronic) IS - 1475-2891 (Linking) VI - 15 DP - 2016 Mar 8 TI - The effect of moderate intensity exercise in the postprandial period on the inflammatory response to a high-fat meal: an experimental study. PG - 24 LID - 10.1186/s12937-016-0134-4 [doi] LID - 24 AB - BACKGROUND: Consuming a high-fat meal (HFM) may lead to postprandial lipemia (PPL) and inflammation. Postprandial exercise has been shown to effectively attenuate PPL. However, little is known about the impact of postprandial exercise on systemic inflammation and whether PPL and inflammation are associated. The purpose of this study was to determine whether moderate intensity exercise performed 60 min following a true-to-life HFM would attenuate PPL and inflammation. METHODS: Thirty-nine young adults (18-40 year) with no known metabolic disease were randomized to either a control group (CON) who remained sedentary during the postprandial period or an exercise (EX) group who walked at 60 % VO2peak to expend approximately 5 kcal/kgbw one-hour following the HFM. Participants consumed a HFM of 10 kcal/kgbw and blood draws were performed immediately before, 2 h and 4 h post-HFM. RESULTS: At baseline, there were no differences between EX and CON groups for any metabolic or inflammatory markers (p > 0.05). Postprandial triglycerides (TRG) increased from baseline to 4 h in the EX and CON groups (p < 0.001), with no differences between groups (p = 0.871). High density lipoprotein cholesterol (HDL-C) decreased in both groups across time (p < 0.001) with no differences between groups (p = 0.137). Interleukin-6 (IL-6) was significant as a quadratic function over time (p = 0.005), decreasing from baseline to 2 h then increasing and returning to baseline at 4 h in all participants with no difference between groups (p = 0.276). Tumor necrosis factor-alpha (TNF-alpha) was not different from baseline to 4 h between groups (p > 0.05). There was an increase in soluble vascular adhesion molecule (sVCAM-1) from baseline to 4 h (p = 0.027) for all participants along with a group x time interaction (p = 0.020). Changes in TRG were associated with changes in interleukin-10 (IL-10) from 0 to 2 h (p = 0.007), but were not associated with changes in any other inflammatory marker in the postprandial period (p > 0.05). CONCLUSIONS: Despite significant increases in PPL following a HFM, moderate intensity exercise in the postprandial period did not mitigate the PPL nor the inflammatory response to the HFM. These results indicate that in populations with low metabolic risk, PPL and inflammation following a HFM may not be directly related. FAU - Teeman, Colby S AU - Teeman CS AD - Department of Food, Nutrition, Dietetics and Health, Kansas State University, 212 Justin Hall, 1324 Lovers Lane, Manhattan, KS, 66506, USA. cteeman@ksu.edu. AD - Physical Activity and Nutrition-Clinical Research Consortium (PAN-CRC), Department of Human Nutrition, Kansas State University, 1105 Sunset Ave, Manhattan, KS, 66502, USA. cteeman@ksu.edu. FAU - Kurti, Stephanie P AU - Kurti SP AD - Department of Kinesiology, Kansas State University, 1A Natatorium, 920 Denison Ave, Manhattan, KS, 66506, USA. stephkurti@ksu.edu. AD - Physical Activity and Nutrition-Clinical Research Consortium (PAN-CRC), Department of Human Nutrition, Kansas State University, 1105 Sunset Ave, Manhattan, KS, 66502, USA. stephkurti@ksu.edu. FAU - Cull, Brooke J AU - Cull BJ AD - Department of Food, Nutrition, Dietetics and Health, Kansas State University, 212 Justin Hall, 1324 Lovers Lane, Manhattan, KS, 66506, USA. brooke1@ksu.edu. AD - Physical Activity and Nutrition-Clinical Research Consortium (PAN-CRC), Department of Human Nutrition, Kansas State University, 1105 Sunset Ave, Manhattan, KS, 66502, USA. brooke1@ksu.edu. FAU - Emerson, Sam R AU - Emerson SR AD - Department of Food, Nutrition, Dietetics and Health, Kansas State University, 212 Justin Hall, 1324 Lovers Lane, Manhattan, KS, 66506, USA. same@ksu.edu. AD - Physical Activity and Nutrition-Clinical Research Consortium (PAN-CRC), Department of Human Nutrition, Kansas State University, 1105 Sunset Ave, Manhattan, KS, 66502, USA. same@ksu.edu. FAU - Haub, Mark D AU - Haub MD AD - Department of Food, Nutrition, Dietetics and Health, Kansas State University, 212 Justin Hall, 1324 Lovers Lane, Manhattan, KS, 66506, USA. haub@ksu.edu. AD - Physical Activity and Nutrition-Clinical Research Consortium (PAN-CRC), Department of Human Nutrition, Kansas State University, 1105 Sunset Ave, Manhattan, KS, 66502, USA. haub@ksu.edu. FAU - Rosenkranz, Sara K AU - Rosenkranz SK AD - Department of Food, Nutrition, Dietetics and Health, Kansas State University, 212 Justin Hall, 1324 Lovers Lane, Manhattan, KS, 66506, USA. sararose@ksu.edu. AD - Physical Activity and Nutrition-Clinical Research Consortium (PAN-CRC), Department of Human Nutrition, Kansas State University, 1105 Sunset Ave, Manhattan, KS, 66502, USA. sararose@ksu.edu. LA - eng PT - Journal Article PT - Randomized Controlled Trial DEP - 20160308 PL - England TA - Nutr J JT - Nutrition journal JID - 101152213 RN - 0 (Blood Glucose) RN - 0 (Cholesterol, HDL) RN - 0 (Cholesterol, LDL) RN - 0 (Dietary Fats) RN - 0 (Interleukin-6) RN - 0 (Triglycerides) RN - 0 (Tumor Necrosis Factor-alpha) RN - 130068-27-8 (Interleukin-10) SB - IM MH - Adolescent MH - Adult MH - Anthropometry MH - Blood Glucose/metabolism MH - Cholesterol, HDL/blood MH - Cholesterol, LDL/blood MH - Dietary Fats/*administration & dosage MH - Exercise/*physiology MH - Female MH - Humans MH - Hyperlipidemias/blood/therapy MH - Inflammation/*blood MH - Interleukin-10/blood MH - Interleukin-6/blood MH - Male MH - Meals MH - Oxygen Consumption MH - Postprandial Period/*physiology MH - Surveys and Questionnaires MH - Triglycerides/blood MH - Tumor Necrosis Factor-alpha/blood MH - Young Adult PMC - PMC4784313 EDAT- 2016/03/10 06:00 MHDA- 2016/10/21 06:00 PMCR- 2016/03/08 CRDT- 2016/03/10 06:00 PHST- 2015/10/14 00:00 [received] PHST- 2016/01/26 00:00 [accepted] PHST- 2016/03/10 06:00 [entrez] PHST- 2016/03/10 06:00 [pubmed] PHST- 2016/10/21 06:00 [medline] PHST- 2016/03/08 00:00 [pmc-release] AID - 10.1186/s12937-016-0134-4 [pii] AID - 134 [pii] AID - 10.1186/s12937-016-0134-4 [doi] PST - epublish SO - Nutr J. 2016 Mar 8;15:24. doi: 10.1186/s12937-016-0134-4.