PMID- 26956891
OWN - NLM
STAT- MEDLINE
DCOM- 20161213
LR  - 20181113
IS  - 1477-7819 (Electronic)
IS  - 1477-7819 (Linking)
VI  - 14
DP  - 2016 Mar 8
TI  - Downregulation of selenium-binding protein 1 is associated with poor prognosis in 
      lung squamous cell carcinoma.
PG  - 70
LID - 10.1186/s12957-016-0832-6 [doi]
LID - 70
AB  - BACKGROUND: We found that selenium-binding protein 1 (SBP1) was progressively 
      decreased in the human bronchial epithelial carcinogenic processes. Knockdown of 
      SBP1 in immortalized human bronchial epithelial cell line 16HBE cells 
      significantly increased the efficiency of B[a]P-induced cell transformation. 
      However, the relationship between SBP1 expression and clinicopathological factors 
      of patients has not been defined completely. The specific role of SBP1 in 
      prognosis of lung squamous cell carcinoma (LSCC) is still unknown. METHODS: 
      Tissue samples from 82 patients treated by pulmonary lobectomy for LSCC were 
      used. Immunohistochemistry and western blotting were used to detect the 
      expressions of SBP1 protein. The relationships between the expression level of 
      SBP1 and the clinicopathological features of patients were analyzed. Cox 
      proportional hazard regression analysis and Kaplan-Meier method were used to 
      perform survival analysis. RESULTS: Expressions of SBP1 proteins were 
      significantly lower in LSCC tissues than that in the corresponding normal 
      bronchial epithelium (NBE) tissues (P = 0.000). In LSCC, The expression levels of 
      SBP1 had not correlated with patients' age, gender, smoking state, primary tumor 
      stages (T), TNM clinical stages, and distant metastasis (M) (P > 0.05). However, 
      downregulation of SBP1 was significantly associated with higher lymph node 
      metastasis and lower overall survival rate (P < 0.05). Cox regression analysis 
      indicated low expressions of SBP1 can be an independent prognostic factor for 
      poor overall survival in LSCC patients (P = 0.002). CONCLUSIONS: Downregulation 
      of SBP1 may play a key role in the tumorigenic process of LSCC. SBP1 may be a 
      novel potential prognostic factor of LSCC.
FAU - Tan, Xing
AU  - Tan X
AD  - School of Nursing, University of South China, 28# Changsheng Road West, Hengyang, 
      421001, Hunan, China. 445679540@qq.com.
FAU - Liao, Li
AU  - Liao L
AD  - School of Nursing, University of South China, 28# Changsheng Road West, Hengyang, 
      421001, Hunan, China. 254251558@qq.com.
FAU - Wan, Yan-Ping
AU  - Wan YP
AD  - School of Nursing, University of South China, 28# Changsheng Road West, Hengyang, 
      421001, Hunan, China. wanyy1991@aliyun.com.
FAU - Li, Mei-Xiang
AU  - Li MX
AD  - School of Medicine, University of South China, Hengyang, 421001, China. 
      meixiangle@163.com.
FAU - Chen, Si-Han
AU  - Chen SH
AD  - School of Medicine, University of South China, Hengyang, 421001, China. 
      172140411@qq.com.
FAU - Mo, Wen-Juan
AU  - Mo WJ
AD  - School of Nursing, University of South China, 28# Changsheng Road West, Hengyang, 
      421001, Hunan, China. 764971367@qq.com.
FAU - Zhao, Qiong-Lan
AU  - Zhao QL
AD  - School of Nursing, University of South China, 28# Changsheng Road West, Hengyang, 
      421001, Hunan, China. 386212360@qq.com.
FAU - Huang, Li-Fang
AU  - Huang LF
AD  - School of Nursing, University of South China, 28# Changsheng Road West, Hengyang, 
      421001, Hunan, China. 450392434@qq.com.
FAU - Zeng, Gu-Qing
AU  - Zeng GQ
AD  - School of Nursing, University of South China, 28# Changsheng Road West, Hengyang, 
      421001, Hunan, China. zengguqing0123@163.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20160308
PL  - England
TA  - World J Surg Oncol
JT  - World journal of surgical oncology
JID - 101170544
RN  - 0 (Biomarkers, Tumor)
RN  - 0 (Selenium-Binding Proteins)
SB  - IM
MH  - Biomarkers, Tumor/*metabolism
MH  - Blotting, Western
MH  - Carcinoma, Squamous Cell/metabolism/*secondary
MH  - Down-Regulation
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Immunoenzyme Techniques
MH  - Lung Neoplasms/metabolism/*pathology
MH  - Lymphatic Metastasis
MH  - Male
MH  - Middle Aged
MH  - Neoplasm Staging
MH  - Prognosis
MH  - Selenium-Binding Proteins/*metabolism
MH  - Survival Rate
PMC - PMC4782367
EDAT- 2016/03/10 06:00
MHDA- 2016/12/15 06:00
PMCR- 2016/03/08
CRDT- 2016/03/10 06:00
PHST- 2015/07/30 00:00 [received]
PHST- 2016/03/01 00:00 [accepted]
PHST- 2016/03/10 06:00 [entrez]
PHST- 2016/03/10 06:00 [pubmed]
PHST- 2016/12/15 06:00 [medline]
PHST- 2016/03/08 00:00 [pmc-release]
AID - 10.1186/s12957-016-0832-6 [pii]
AID - 832 [pii]
AID - 10.1186/s12957-016-0832-6 [doi]
PST - epublish
SO  - World J Surg Oncol. 2016 Mar 8;14:70. doi: 10.1186/s12957-016-0832-6.