PMID- 26956903
OWN - NLM
STAT- MEDLINE
DCOM- 20170214
LR  - 20220310
IS  - 1432-2323 (Electronic)
IS  - 0364-2313 (Linking)
VI  - 40
IP  - 7
DP  - 2016 Jul
TI  - Minimally Invasive Versus Open Pancreatic Surgery in Patients with Multiple 
      Endocrine Neoplasia Type 1.
PG  - 1729-36
LID - 10.1007/s00268-016-3456-7 [doi]
AB  - OBJECTIVE: The role of minimally invasive pancreatic surgery for pancreatic 
      neuroendocrine neoplasms (pNENs) in patients with multiple endocrine neoplasia 
      type 1 (MEN1) is not well defined. The aim of this study was to compare the 
      outcome of minimally invasive versus open pancreatic resections in patients with 
      MEN1. MATERIALS AND METHODS: Prospectively collected data of MEN1 patients who 
      underwent a primary distal pancreatic resection and/or enucleation for 
      non-functioning pNENs or insulinoma were retrospectively analyzed regarding the 
      outcome of minimally invasive or open pancreatic resections. RESULTS: 
      Thirty-three patients underwent primary pancreatic resection for either organic 
      hyperinsulinism (n = 9, 27 %) or non-functioning pNENs >1 cm in size (n = 24, 
      73 %) between 1987 and 2015. 21 (64 %) patients underwent an open surgical (group 
      1) and 12 patients (36 %) a minimally invasive approach, either laparoscopic 
      (n = 8) or robotic assisted (n = 4) (group 2). Both groups were comparable 
      regarding age, gender, number, and size of pancreatic tumors. In both groups, the 
      hyperinsulinism of all patients (9/9,100 %) could be cured and all NF-pNENs >1 cm 
      could be resected. Group 2 had a significant shorter operative time (200 vs. 
      260 min; p = 0.036), less intraoperative blood loss (120 vs. 280 ml; p < 0.001), 
      and a shorter hospital stay (11 vs. 15.5 days; p = 0.034). The rate of patients 
      with postoperative complications, especially postoperative pancreatic fistulas, 
      was not different between groups (62 % group 1 vs. 67 % group 2, p = 0.74). 
      CONCLUSION: Minimally invasive distal pancreatic resections and enucleations are 
      feasible and safe in MEN1 patients with insulinoma or non-functioning pNENs.
FAU - Lopez, Caroline L
AU  - Lopez CL
AD  - Department of Visceral, Thoracic and Vascular Surgery, Philipps University 
      Marburg, 35041, Baldingerstrasse, Marburg, Germany. lopez@med.uni-marburg.de.
FAU - Albers, Max B
AU  - Albers MB
AD  - Department of Visceral, Thoracic and Vascular Surgery, Philipps University 
      Marburg, 35041, Baldingerstrasse, Marburg, Germany.
FAU - Bollmann, Carmen
AU  - Bollmann C
AD  - Department of Visceral, Thoracic and Vascular Surgery, Philipps University 
      Marburg, 35041, Baldingerstrasse, Marburg, Germany.
FAU - Manoharan, Jerena
AU  - Manoharan J
AD  - Department of Visceral, Thoracic and Vascular Surgery, Philipps University 
      Marburg, 35041, Baldingerstrasse, Marburg, Germany.
FAU - Waldmann, Jens
AU  - Waldmann J
AD  - Department of Visceral, Thoracic and Vascular Surgery, Philipps University 
      Marburg, 35041, Baldingerstrasse, Marburg, Germany.
FAU - Fendrich, Volker
AU  - Fendrich V
AD  - Department of Visceral, Thoracic and Vascular Surgery, Philipps University 
      Marburg, 35041, Baldingerstrasse, Marburg, Germany.
FAU - Bartsch, Detlef K
AU  - Bartsch DK
AD  - Department of Visceral, Thoracic and Vascular Surgery, Philipps University 
      Marburg, 35041, Baldingerstrasse, Marburg, Germany.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - World J Surg
JT  - World journal of surgery
JID - 7704052
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Child
MH  - Female
MH  - Humans
MH  - Insulinoma/*surgery
MH  - Laparoscopy
MH  - Male
MH  - Middle Aged
MH  - *Minimally Invasive Surgical Procedures
MH  - Multiple Endocrine Neoplasia Type 1/*surgery
MH  - Neuroendocrine Tumors/*surgery
MH  - *Pancreatectomy
MH  - Pancreatic Fistula/*epidemiology
MH  - Pancreatic Neoplasms/*surgery
MH  - Postoperative Complications/*epidemiology
MH  - Retrospective Studies
MH  - Robotic Surgical Procedures
MH  - Treatment Outcome
MH  - Young Adult
EDAT- 2016/03/10 06:00
MHDA- 2017/02/15 06:00
CRDT- 2016/03/10 06:00
PHST- 2016/03/10 06:00 [entrez]
PHST- 2016/03/10 06:00 [pubmed]
PHST- 2017/02/15 06:00 [medline]
AID - 10.1007/s00268-016-3456-7 [pii]
AID - 10.1007/s00268-016-3456-7 [doi]
PST - ppublish
SO  - World J Surg. 2016 Jul;40(7):1729-36. doi: 10.1007/s00268-016-3456-7.