PMID- 26956917
OWN - NLM
STAT- MEDLINE
DCOM- 20170103
LR  - 20181113
IS  - 2045-2322 (Electronic)
IS  - 2045-2322 (Linking)
VI  - 6
DP  - 2016 Mar 9
TI  - Interleukin-31 expression and relation to disease severity in human asthma.
PG  - 22835
LID - 10.1038/srep22835 [doi]
LID - 22835
AB  - Interleukin 31 (IL-31) is a novel T helper type 2 effector cytokine that plays an 
      important role in the pathogenesis of allergic diseases. However, its role in 
      human asthma remains unclear. The aim of this study was to measure IL-31 levels 
      in the serum, bronchoalveolar lavage fluid (BALF) and bronchial tissue of 
      asthmatics and healthy subjects, and identify its possible correlation to disease 
      severity. We quantified IL-31 levels in the serum of patients with asthma 
      (n = 44), as well as in controls (n = 22). Of these subjects, 9 asthmatics and 
      five controls underwent bronchoscopy with endobronchial biopsy and BALF 
      collection. Our data showed that serum and BALF IL-31 levels were significantly 
      elevated in patients with asthma compared with controls. Expressions of IL-31 and 
      IL-31 receptor (IL-31RA and OSMR) were more prominent in the bronchial tissue in 
      severe compared to mild asthma and controls. Serum IL-31 levels correlated 
      positively with Th2 related cytokines (IL-5, IL-13, and TSLP), asthma severity or 
      total serum immunoglobulin E (IgE), and inversely with asthma control and the 
      forced expiratory volume in 1 second (FEV1). The current data may provide insight 
      into the underlying pathogenesis of asthma, in which IL-31 has an important 
      pathogenic role.
FAU - Lai, Tianwen
AU  - Lai T
AD  - Department of Respiratory and Critical Care Medicine, Affiliated Hospital, 
      Institute of Respiratory Diseases, Guangdong Medical College, Zhanjiang, China.
FAU - Wu, Dong
AU  - Wu D
AD  - Department of Respiratory and Critical Care Medicine, Affiliated Hospital, 
      Institute of Respiratory Diseases, Guangdong Medical College, Zhanjiang, China.
FAU - Li, Wen
AU  - Li W
AD  - Department of Respiratory and Critical Care Medicine, Affiliated Hospital, 
      Institute of Respiratory Diseases, Guangdong Medical College, Zhanjiang, China.
FAU - Chen, Min
AU  - Chen M
AD  - Department of Respiratory and Critical Care Medicine, Affiliated Hospital, 
      Institute of Respiratory Diseases, Guangdong Medical College, Zhanjiang, China.
FAU - Yi, Zhennan
AU  - Yi Z
AD  - Department of Respiratory and Critical Care Medicine, Affiliated Hospital, 
      Institute of Respiratory Diseases, Guangdong Medical College, Zhanjiang, China.
FAU - Huang, Dan
AU  - Huang D
AD  - Department of Respiratory and Critical Care Medicine, Affiliated Hospital, 
      Institute of Respiratory Diseases, Guangdong Medical College, Zhanjiang, China.
FAU - Jing, Zhiliang
AU  - Jing Z
AD  - Department of pathology, Affiliated Hospital, Guangdong Medical College, 
      Zhanjiang, China.
FAU - Lu, Yingying
AU  - Lu Y
AD  - Department of Respiratory and Critical Care Medicine, Affiliated Hospital, 
      Institute of Respiratory Diseases, Guangdong Medical College, Zhanjiang, China.
FAU - Lv, Quanchao
AU  - Lv Q
AD  - Department of Respiratory and Critical Care Medicine, Affiliated Hospital, 
      Institute of Respiratory Diseases, Guangdong Medical College, Zhanjiang, China.
FAU - Li, Dongming
AU  - Li D
AD  - Department of Respiratory and Critical Care Medicine, Affiliated Hospital, 
      Institute of Respiratory Diseases, Guangdong Medical College, Zhanjiang, China.
FAU - Wu, Bin
AU  - Wu B
AD  - Department of Respiratory and Critical Care Medicine, Affiliated Hospital, 
      Institute of Respiratory Diseases, Guangdong Medical College, Zhanjiang, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20160309
PL  - England
TA  - Sci Rep
JT  - Scientific reports
JID - 101563288
RN  - 0 (IL31 protein, human)
RN  - 0 (Interleukins)
SB  - IM
MH  - Adult
MH  - Asthma/*pathology
MH  - Blood Chemical Analysis
MH  - Bronchi/chemistry
MH  - Bronchoalveolar Lavage Fluid/chemistry
MH  - Female
MH  - Humans
MH  - Interleukins/*analysis/*blood
MH  - Male
MH  - Middle Aged
MH  - Respiratory Mucosa/chemistry
PMC - PMC4783779
EDAT- 2016/03/10 06:00
MHDA- 2017/01/04 06:00
PMCR- 2016/03/09
CRDT- 2016/03/10 06:00
PHST- 2015/10/09 00:00 [received]
PHST- 2016/02/19 00:00 [accepted]
PHST- 2016/03/10 06:00 [entrez]
PHST- 2016/03/10 06:00 [pubmed]
PHST- 2017/01/04 06:00 [medline]
PHST- 2016/03/09 00:00 [pmc-release]
AID - srep22835 [pii]
AID - 10.1038/srep22835 [doi]
PST - epublish
SO  - Sci Rep. 2016 Mar 9;6:22835. doi: 10.1038/srep22835.