PMID- 26958340
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20160309
LR  - 20220309
IS  - 2047-1440 (Print)
IS  - 2047-1440 (Electronic)
IS  - 2047-1440 (Linking)
VI  - 5
DP  - 2016
TI  - Some considerations on the current debate about typing resolution in solid organ 
      transplantation.
PG  - 3
LID - 10.1186/s13737-016-0032-5 [doi]
LID - 3
AB  - BACKGROUND: The shortage of suitable organs and achieved tolerance are 
      uncontested main concerns in transplantation. Long waiting lists for deceased 
      donors and limited numbers of living donors are the current scenarios. Kidney 
      grafts from living donors have better overall survival compared to cadaveric and 
      require less aggressive immunosuppressive regimens. The human leukocyte antigen 
      (HLA) labs have the key role to test the recipient and donors compatibility based 
      on typing and antibody profile. The current standard molecular procedure in solid 
      organ transplantation is low-resolution typing, at the antigen level. MAIN TEXT: 
      In this commentary, the merits of high versus low degree of typing resolution in 
      solid organ transplantation are discussed. Critical questions and reasons to 
      bring high-resolution typing as a routine test in health system are considered. 
      Specifically, with the introduction of the next-generation sequencing (NGS) in 
      HLA, the pros and cons in living donation and benefits after deceased donation 
      are critically evaluated. CONCLUSION: NGS has the potential to improve the 
      transplant rates and the overall graft survival. Alternative strategies to 
      increase in demanding the number of transplants are briefly highlighted.
FAU - Vogiatzi, Paraskevi
AU  - Vogiatzi P
AD  - Department of Pathology, Tissue Typing Laboratory, University of Michigan, 2900 
      Huron Parkway, Ann Arbor, MI 48105 USA.
LA  - eng
PT  - Journal Article
DEP - 20160308
PL  - England
TA  - Transplant Res
JT  - Transplantation research
JID - 101597592
PMC - PMC4782307
OTO - NOTNLM
OT  - Allele-based mismatch
OT  - Antigen-based mismatch
OT  - Cadaveric donor
OT  - HLA typing
OT  - Living donor
OT  - Next generation sequencing
OT  - Solid organ transplantation
EDAT- 2016/03/10 06:00
MHDA- 2016/03/10 06:01
PMCR- 2016/03/08
CRDT- 2016/03/10 06:00
PHST- 2015/07/01 00:00 [received]
PHST- 2016/01/28 00:00 [accepted]
PHST- 2016/03/10 06:00 [entrez]
PHST- 2016/03/10 06:00 [pubmed]
PHST- 2016/03/10 06:01 [medline]
PHST- 2016/03/08 00:00 [pmc-release]
AID - 32 [pii]
AID - 10.1186/s13737-016-0032-5 [doi]
PST - epublish
SO  - Transplant Res. 2016 Mar 8;5:3. doi: 10.1186/s13737-016-0032-5. eCollection 2016.