PMID- 26959059
OWN - NLM
STAT- MEDLINE
DCOM- 20161213
LR  - 20220408
IS  - 2072-6643 (Electronic)
IS  - 2072-6643 (Linking)
VI  - 8
IP  - 3
DP  - 2016 Mar 5
TI  - The Potential Protective Action of Vitamin D in Hepatic Insulin Resistance and 
      Pancreatic Islet Dysfunction in Type 2 Diabetes Mellitus.
PG  - 147
LID - 10.3390/nu8030147 [doi]
LID - 147
AB  - Vitamin D deficiency (i.e., hypovitaminosis D) is associated with increased 
      insulin resistance, impaired insulin secretion, and poorly controlled glucose 
      homeostasis, and thus is correlated with the risk of metabolic diseases, 
      including type 2 diabetes mellitus (T2DM). The liver plays key roles in glucose 
      and lipid metabolism, and its dysregulation leads to abnormalities in hepatic 
      glucose output and triglyceride accumulation. Meanwhile, the pancreatic islets 
      are constituted in large part by insulin-secreting beta cells. Consequently, islet 
      dysfunction, such as occurs in T2DM, produces hyperglycemia. In this review, we 
      provide a critical appraisal of the modulatory actions of vitamin D in hepatic 
      insulin sensitivity and islet insulin secretion, and we discuss the potential 
      roles of a local vitamin D signaling in regulating hepatic and pancreatic islet 
      functions. This information provides a scientific basis for establishing the 
      benefits of the maintenance, or dietary manipulation, of adequate vitamin D 
      status in the prevention and management of obesity-induced T2DM and non-alcoholic 
      fatty liver disease.
FAU - Leung, Po Sing
AU  - Leung PS
AD  - School of Biomedical Sciences, Faculty of Medicine, The Chinese University of 
      Hong Kong, Shatin, Hong Kong, China. psleung@cuhk.edu.hk.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20160305
PL  - Switzerland
TA  - Nutrients
JT  - Nutrients
JID - 101521595
RN  - 0 (Blood Glucose)
RN  - 0 (Insulin)
RN  - 1406-16-2 (Vitamin D)
SB  - IM
MH  - Animals
MH  - Blood Glucose/metabolism
MH  - Diabetes Mellitus, Type 2/epidemiology/*metabolism/physiopathology/prevention & 
      control
MH  - Humans
MH  - Insulin/blood
MH  - *Insulin Resistance
MH  - Islets of Langerhans/*metabolism/physiopathology
MH  - Liver/*metabolism/physiopathology
MH  - Protective Factors
MH  - Risk Factors
MH  - Signal Transduction
MH  - Vitamin D/*metabolism
MH  - Vitamin D Deficiency/epidemiology/*metabolism/physiopathology
PMC - PMC4808876
OTO - NOTNLM
OT  - HepG2
OT  - calcitriol
OT  - glucose homeostasis
OT  - hypovitaminosis D
OT  - insulin secretion
OT  - lipid metabolism
EDAT- 2016/03/10 06:00
MHDA- 2016/12/15 06:00
PMCR- 2016/03/01
CRDT- 2016/03/10 06:00
PHST- 2015/11/20 00:00 [received]
PHST- 2016/02/26 00:00 [revised]
PHST- 2016/02/29 00:00 [accepted]
PHST- 2016/03/10 06:00 [entrez]
PHST- 2016/03/10 06:00 [pubmed]
PHST- 2016/12/15 06:00 [medline]
PHST- 2016/03/01 00:00 [pmc-release]
AID - nu8030147 [pii]
AID - nutrients-08-00147 [pii]
AID - 10.3390/nu8030147 [doi]
PST - epublish
SO  - Nutrients. 2016 Mar 5;8(3):147. doi: 10.3390/nu8030147.