PMID- 26959740
OWN - NLM
STAT- MEDLINE
DCOM- 20170131
LR  - 20181113
IS  - 1949-2553 (Electronic)
IS  - 1949-2553 (Linking)
VI  - 7
IP  - 14
DP  - 2016 Apr 5
TI  - A single-nucleotide polymorphism in the 3'-UTR region of the adipocyte fatty acid 
      binding protein 4 gene is associated with prognosis of triple-negative breast 
      cancer.
PG  - 18984-98
LID - 10.18632/oncotarget.7920 [doi]
AB  - Triple-negative breast cancer (TNBC) is a subtype of breast cancer with poor 
      prognosis and high heterogeneity. The aim of this study was to screen patients 
      for single-nucleotide polymorphisms (SNPs) associated with the prognosis of TNBC. 
      Database-derived SNPs (NextBio, Ensembl, NCBI and MirSNP) located in the 
      3'-untranslated regions (3'-UTRs) of genes that are differentially expressed in 
      breast cancer were selected. The possible associations between 111 SNPs and 
      progression risk among 323 TNBC patients were investigated using a two-step 
      case-control study with a discovery cohort (n=162) and a validation cohort 
      (n=161). We identified the rs1054135 SNP in the adipocyte fatty acid binding 
      protein 4 (FABP4) gene as a predictor of TNBC recurrence. The G allele of 
      rs1054135 was associated with a reduced risk of disease progression as well as a 
      prolonged disease-free survival time (DFS), with a hazard ratio (HR) for 
      recurrence in the combined sample of 0.269 [95%CI: 0.098-0.735;P=0.001]. Notably, 
      for individuals having the rs1054135 SNP with the AA/AG genotype, the magnitude 
      of increased tumour recurrence risk for overweight patients (BMI>/=25kg/m2) was 
      significantly elevated (HR2.53; 95%CI: 1.06-6.03). Immunohistochemical staining 
      of adipocytes adjacent to TNBC tissues showed that the expression level of FABP4 
      was statistically significantly lower in patients with the rs1054135-GG genotype 
      and those in the disease-free group (P=0.0004 and P=0.0091, respectively). These 
      results suggested that the expression of a lipid metabolism-related gene and an 
      important SNP in the 3'-UTR of FABP4 are associated with TNBC prognosis, which 
      may aid in the screening of high-risk patients with TNBC recurrence and the 
      development of novel chemotherapeutic agents.
FAU - Wang, Wenmiao
AU  - Wang W
AD  - Department of Medical Oncology, Cancer Institute and Hospital, Peking Union 
      Medical College, Chinese Academy of Medical Sciences, Beijing, P.R. China.
AD  - Phase I Clinical Trial Center, Beijing Shijitan Hospital, Capital Medical 
      University, The 9th Clinical College, Beijing, P.R. China.
FAU - Yuan, Peng
AU  - Yuan P
AD  - Department of Medical Oncology, Cancer Institute and Hospital, Peking Union 
      Medical College, Chinese Academy of Medical Sciences, Beijing, P.R. China.
FAU - Yu, Dianke
AU  - Yu D
AD  - Department of Etiology and Carcinogenesis, Cancer Institute and Hospital, Chinese 
      Academy of Medical Science and Peking Union Medical College, Beijing, P.R. China.
FAU - Du, Feng
AU  - Du F
AD  - Department of Medical Oncology, Cancer Institute and Hospital, Peking Union 
      Medical College, Chinese Academy of Medical Sciences, Beijing, P.R. China.
FAU - Zhu, Anjie
AU  - Zhu A
AD  - Department of Medical Oncology, Cancer Institute and Hospital, Peking Union 
      Medical College, Chinese Academy of Medical Sciences, Beijing, P.R. China.
FAU - Li, Qing
AU  - Li Q
AD  - Department of Medical Oncology, Cancer Institute and Hospital, Peking Union 
      Medical College, Chinese Academy of Medical Sciences, Beijing, P.R. China.
FAU - Zhang, Pin
AU  - Zhang P
AD  - Department of Medical Oncology, Cancer Institute and Hospital, Peking Union 
      Medical College, Chinese Academy of Medical Sciences, Beijing, P.R. China.
FAU - Lin, Dongxin
AU  - Lin D
AD  - Department of Etiology and Carcinogenesis, Cancer Institute and Hospital, Chinese 
      Academy of Medical Science and Peking Union Medical College, Beijing, P.R. China.
FAU - Xu, Binghe
AU  - Xu B
AD  - Department of Medical Oncology, Cancer Institute and Hospital, Peking Union 
      Medical College, Chinese Academy of Medical Sciences, Beijing, P.R. China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Oncotarget
JT  - Oncotarget
JID - 101532965
RN  - 0 (3' Untranslated Regions)
RN  - 0 (FABP4 protein, human)
RN  - 0 (Fatty Acid-Binding Proteins)
SB  - IM
MH  - 3' Untranslated Regions
MH  - Adipocytes/metabolism/pathology
MH  - Adult
MH  - Case-Control Studies
MH  - Cohort Studies
MH  - Disease-Free Survival
MH  - Fatty Acid-Binding Proteins/*genetics/metabolism
MH  - Female
MH  - Genotype
MH  - Humans
MH  - Polymorphism, Single Nucleotide
MH  - Prognosis
MH  - Triple Negative Breast Neoplasms/*genetics/metabolism/pathology
PMC - PMC4951346
OTO - NOTNLM
OT  - 3'-untranslated regions
OT  - FABP4
OT  - genetic variant
OT  - prognosis
OT  - triple-negative breast cancer
COIS- CONFLICTS OF INTEREST The authors declare no conflicts of interest.
EDAT- 2016/03/10 06:00
MHDA- 2017/02/01 06:00
PMCR- 2016/04/05
CRDT- 2016/03/10 06:00
PHST- 2015/07/13 00:00 [received]
PHST- 2016/01/29 00:00 [accepted]
PHST- 2016/03/10 06:00 [entrez]
PHST- 2016/03/10 06:00 [pubmed]
PHST- 2017/02/01 06:00 [medline]
PHST- 2016/04/05 00:00 [pmc-release]
AID - 7920 [pii]
AID - 10.18632/oncotarget.7920 [doi]
PST - ppublish
SO  - Oncotarget. 2016 Apr 5;7(14):18984-98. doi: 10.18632/oncotarget.7920.