PMID- 26960438
OWN - NLM
STAT- MEDLINE
DCOM- 20180102
LR  - 20181113
IS  - 1573-7284 (Electronic)
IS  - 0393-2990 (Print)
IS  - 0393-2990 (Linking)
VI  - 31
IP  - 10
DP  - 2016 Oct
TI  - Proton pump inhibitors and gastroenteritis.
PG  - 1057-1063
AB  - An association between proton pump inhibitor (PPI) therapy and bacterial 
      gastroenteritis has been suggested as well as contradicted. The aim of this study 
      was to examine the association between the use of PPIs and occurrence of 
      bacterial gastroenteritis in the prospective Rotterdam Study. The Rotterdam Study 
      is a population-based cohort study among 14,926 subjects aged 45 years and older 
      with up to 24 years of follow-up. Analyses were performed with a generalized 
      estimating equations method in participants who handed-in a diagnostic stool 
      sample. Furthermore, a nested case-control analysis was performed using the total 
      cohort as a reference group. A bacterial microorganism was isolated in 125 
      samples, whereas 1174 samples were culture negative. In the generalized 
      estimating equations analysis, we found that participants with a bacterial 
      gastroenteritis were more likely than controls to be current users of PPIs 
      (adjusted OR 1.94; 95 % CI 1.15-3.25). Different sensitivity analyses did not 
      change this result. A considerably higher effect was observed (adjusted OR 6.14; 
      95 % CI 3.81-9.91), using the total cohort as a reference in a nested 
      case-control analysis. Current PPI therapy is associated with an increased risk 
      of bacterial gastroenteritis. However, by reducing the risk of selection and 
      information bias in our study design, we demonstrated that the effect is lower 
      than previously assumed.
FAU - Hassing, Robert-Jan
AU  - Hassing RJ
AD  - Department of Epidemiology, Erasmus Medical Centre, Wytemaweg 80, 3015 CN, 
      Rotterdam, The Netherlands.
AD  - Department of Internal Medicine, Rijnstate Hospital, Arnhem, The Netherlands.
FAU - Verbon, Annelies
AU  - Verbon A
AD  - Department of Medical Microbiology and Infectious Diseases, Erasmus Medical 
      Centre, Rotterdam, The Netherlands.
FAU - de Visser, Herman
AU  - de Visser H
AD  - Star Medisch Diagnostisch Centrum, Rotterdam, The Netherlands.
FAU - Hofman, Albert
AU  - Hofman A
AD  - Department of Epidemiology, Erasmus Medical Centre, Wytemaweg 80, 3015 CN, 
      Rotterdam, The Netherlands.
FAU - Stricker, Bruno H
AU  - Stricker BH
AD  - Department of Epidemiology, Erasmus Medical Centre, Wytemaweg 80, 3015 CN, 
      Rotterdam, The Netherlands. b.stricker@erasmusmc.nl.
AD  - Inspectorate of Health Care, Utrecht, The Netherlands. b.stricker@erasmusmc.nl.
LA  - eng
PT  - Journal Article
DEP - 20160310
PL  - Netherlands
TA  - Eur J Epidemiol
JT  - European journal of epidemiology
JID - 8508062
RN  - 0 (Proton Pump Inhibitors)
SB  - IM
MH  - Aged
MH  - Campylobacter Infections/chemically induced
MH  - Case-Control Studies
MH  - Dysentery, Bacillary/chemically induced
MH  - Feces/microbiology
MH  - Female
MH  - Gastroenteritis/*chemically induced/microbiology
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Prospective Studies
MH  - Proton Pump Inhibitors/*adverse effects
MH  - Salmonella Infections/chemically induced
MH  - Yersinia Infections/chemically induced
PMC - PMC5065595
OTO - NOTNLM
OT  - Campylobacter
OT  - Cohort study
OT  - Gastroenteritis
OT  - Proton pump inhibitor
OT  - Salmonella
COIS- Compliance with ethical standards Conflicts of interest All authors report no 
      potential conflicts.
EDAT- 2016/03/11 06:00
MHDA- 2018/01/03 06:00
PMCR- 2016/03/10
CRDT- 2016/03/11 06:00
PHST- 2015/11/02 00:00 [received]
PHST- 2016/03/01 00:00 [accepted]
PHST- 2016/03/11 06:00 [pubmed]
PHST- 2018/01/03 06:00 [medline]
PHST- 2016/03/11 06:00 [entrez]
PHST- 2016/03/10 00:00 [pmc-release]
AID - 10.1007/s10654-016-0136-8 [pii]
AID - 136 [pii]
AID - 10.1007/s10654-016-0136-8 [doi]
PST - ppublish
SO  - Eur J Epidemiol. 2016 Oct;31(10):1057-1063. doi: 10.1007/s10654-016-0136-8. Epub 
      2016 Mar 10.