PMID- 26960692
OWN - NLM
STAT- MEDLINE
DCOM- 20170207
LR  - 20181113
IS  - 1423-0380 (Electronic)
IS  - 1010-4283 (Linking)
VI  - 37
IP  - 8
DP  - 2016 Aug
TI  - Body composition of the host influences dendritic cell phenotype in patients 
      treated for colorectal cancer.
PG  - 11359-64
LID - 10.1007/s13277-016-5009-y [doi]
AB  - Dendritic cells (DCs) are antigen-presenting cells that can acquire tumour 
      antigens and initiate cytotoxic T cell reactions. Obesity has been proposed as a 
      cause for tumours escaping immune surveillance, but few studies investigate the 
      impact of other body composition parameters. We examined the relationship of DC 
      phenotype with computer tomography (CT)-defined parameters in patients with 
      colorectal cancer (CRC). DCs were identified within peripheral blood mononuclear 
      cells by flow cytometry as HLA-DR positive and negative for markers of other cell 
      lineages in 21 patients. Analysis of CT scans was used to calculate lumbar 
      skeletal muscle index (LSMI) and mean muscle attenuation (MA). Positive 
      correlation between the LSMI and expression of CD40 in all DCs (r = 0.45; 
      p = 0.04) was demonstrated. The MA was positively correlated with scavenger 
      receptor CD36 [all DCs (r = 0.60; p = 0.01) and myeloid DCs (r = 0.63; 
      p < 0.01)]. However, the MA was negatively correlated with CCR7 expression in all 
      DCs (r = -0.46, p = 0.03.) and with CD83 [all DCs (r = -0.63; p = 0.01) and 
      myeloid DCs (r = -0.75; p < 0.01)]. There were no relationships between the fat 
      indexes and the DC phenotype. These results highlight a direct relationship 
      between muscle depletion and changes in stimulatory, migratory and fatty 
      acid-processing potential of DC in patients with CRC.
FAU - Malietzis, George
AU  - Malietzis G
AD  - Antigen Presentation Research Group, Imperial College London, North West London 
      Hospitals Campus, Watford Road, Harrow, HA1 3UJ, UK.
AD  - Department of Surgery, St. Mark's Hospital, Watford Road, Harrow Middlesex, HA1 
      3UJ, UK.
FAU - Lee, Gui Han
AU  - Lee GH
AD  - Antigen Presentation Research Group, Imperial College London, North West London 
      Hospitals Campus, Watford Road, Harrow, HA1 3UJ, UK.
AD  - Department of Surgery, St. Mark's Hospital, Watford Road, Harrow Middlesex, HA1 
      3UJ, UK.
FAU - Al-Hassi, Hafid O
AU  - Al-Hassi HO
AD  - Antigen Presentation Research Group, Imperial College London, North West London 
      Hospitals Campus, Watford Road, Harrow, HA1 3UJ, UK.
FAU - Bernardo, David
AU  - Bernardo D
AD  - Antigen Presentation Research Group, Imperial College London, North West London 
      Hospitals Campus, Watford Road, Harrow, HA1 3UJ, UK.
AD  - Gastroenterology Unit, Hospital Universitario de La Princesa and Instituto de 
      Investigacion Sanitaria Princesa (IIS-IP), Centro de Investigacion Biomedica en 
      Red de Enfermedades Hepaticas y Digestivas (CIBEREHD), Madrid, 28006, Spain.
FAU - Blakemore, Alexandra I F
AU  - Blakemore AI
AD  - Section of Investigative Medicine, Division of Diabetes, Endocrinology, and 
      Metabolism, Faculty of Medicine|, Imperial College, London, W12 0NN, UK.
AD  - Department of Life Sciences, Brunel University London, Middlesex, UB8 3PH, UK.
FAU - Kennedy, Robin H
AU  - Kennedy RH
AD  - Department of Surgery, St. Mark's Hospital, Watford Road, Harrow Middlesex, HA1 
      3UJ, UK.
FAU - Moorghen, Morgan
AU  - Moorghen M
AD  - Department of Histopathology, St. Mark's Hospital, Watford Road, Harrow 
      Middlesex, HA1 3UJ, UK.
FAU - Jenkins, John T
AU  - Jenkins JT
AD  - Department of Surgery, St. Mark's Hospital, Watford Road, Harrow Middlesex, HA1 
      3UJ, UK.
FAU - Knight, Stella C
AU  - Knight SC
AD  - Antigen Presentation Research Group, Imperial College London, North West London 
      Hospitals Campus, Watford Road, Harrow, HA1 3UJ, UK. s.knight@imperial.ac.uk.
LA  - eng
PT  - Journal Article
DEP - 20160310
PL  - Netherlands
TA  - Tumour Biol
JT  - Tumour biology : the journal of the International Society for Oncodevelopmental 
      Biology and Medicine
JID - 8409922
SB  - IM
MH  - Adult
MH  - Aged
MH  - Body Composition/*immunology
MH  - Colorectal Neoplasms/*immunology/*pathology
MH  - Dendritic Cells/*immunology
MH  - Female
MH  - Flow Cytometry
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Phenotype
MH  - Tomography, X-Ray Computed
OTO - NOTNLM
OT  - Body composition
OT  - Colorectal cancer
OT  - Dendritic cells
OT  - Myopenia
EDAT- 2016/03/11 06:00
MHDA- 2017/02/09 06:00
CRDT- 2016/03/11 06:00
PHST- 2015/10/29 00:00 [received]
PHST- 2016/03/01 00:00 [accepted]
PHST- 2016/03/11 06:00 [entrez]
PHST- 2016/03/11 06:00 [pubmed]
PHST- 2017/02/09 06:00 [medline]
AID - 10.1007/s13277-016-5009-y [pii]
AID - 10.1007/s13277-016-5009-y [doi]
PST - ppublish
SO  - Tumour Biol. 2016 Aug;37(8):11359-64. doi: 10.1007/s13277-016-5009-y. Epub 2016 
      Mar 10.