PMID- 26960698
OWN - NLM
STAT- MEDLINE
DCOM- 20161213
LR  - 20181113
IS  - 1432-2072 (Electronic)
IS  - 0033-3158 (Linking)
VI  - 233
IP  - 8
DP  - 2016 Apr
TI  - Rottlerin impairs the formation and maintenance of psychostimulant-supported 
      memory.
PG  - 1455-65
LID - 10.1007/s00213-016-4251-8 [doi]
AB  - RATIONALE AND OBJECTIVE: Since brain proteins such as protein kinase C (PKC), 
      brain-derived neurotrophic factor (BDNF), and mammalian target of rapamycin 
      (mTOR) are involved in the establishment and maintenance of psychostimulant 
      memory, we sought to determine if systemic treatment with rottlerin, a natural 
      compound affecting all these proteins, may modulate stimulant-supported memory. 
      MATERIALS AND METHODS: Stimulant-induced conditioned place preference (CPP) was 
      used in modeling stimulant-supported memory. RESULTS: Three cocaine (10 mg/kg; 
      COC) or three methamphetamine (1 mg/kg; MA) conditioning trials reliably 
      established the drug-induced CPP in male C57BL/6 mice. An intra-peritoneal 
      rottlerin injection (5 mg/kg) at least 24 h prior to the first COC or first MA 
      conditioning trial prevented the establishment of CPP. Following the 
      establishment of the COC- or MA-induced CPP, saline conditioning trial was used 
      to extinguish the CPP. Rottlerin (5 mg/kg, intra-peritoneal (i.p.)) administered 
      20 h prior to the first saline conditioning trial diminished subsequent drug- and 
      stressor-primed reinstatement of the extinguished CPP. Rottlerin (5 mg/kg, i.p.) 
      produced a fast-onset and long-lasting increase in hippocampal BDNF levels. 
      However, treatment with a BDNF tropomyosin receptor kinase B (TrkB) receptor 
      antagonist, K252a (5 mug/kg), did not affect rottlerin's suppressing effect on 
      COC-induced CPP and treatment with 7,8-dihydroxyflavone (10 mg/kg x 6, 7,8-DHF), 
      a selective TrkB agonist, prior to each conditioning trial did not affect 
      COC-induced CPP. CONCLUSION: These results suggest that systemic rottlerin 
      treatment may impair the formation of COC- and MA-supported memory. Importantly, 
      such a treatment may advance our understanding of the underlying mechanism 
      through which extinction training resulted in the "forgetting" of the COC- and 
      MA-supported memory.
FAU - Liao, Tien You
AU  - Liao TY
AD  - Institute of Behavioral Medicine, National Cheng Kung University College of 
      Medicine, 1 University Rd., Tainan, 70101, Taiwan, ROC.
FAU - Tzeng, Wen-Yu
AU  - Tzeng WY
AD  - Institute of Behavioral Medicine, National Cheng Kung University College of 
      Medicine, 1 University Rd., Tainan, 70101, Taiwan, ROC.
FAU - Wu, Hsin-Hua
AU  - Wu HH
AD  - Institute of Behavioral Medicine, National Cheng Kung University College of 
      Medicine, 1 University Rd., Tainan, 70101, Taiwan, ROC.
FAU - Cherng, Chianfang G
AU  - Cherng CG
AD  - Department of Health Psychology, Chang Jung Christian University, Tainan, 71101, 
      Taiwan, ROC.
FAU - Wang, Ching-Yi
AU  - Wang CY
AD  - Institute of Basic Medical Sciences, National Cheng Kung University College of 
      Medicine, Tainan, 70101, Taiwan, ROC.
FAU - Hu, Sherry S-J
AU  - Hu SS
AD  - Department of Psychology, National Cheng Kung University, Tainan, 70101, Taiwan, 
      ROC.
FAU - Yu, Lung
AU  - Yu L
AD  - Institute of Behavioral Medicine, National Cheng Kung University College of 
      Medicine, 1 University Rd., Tainan, 70101, Taiwan, ROC. lungyu@mail.ncku.edu.tw.
AD  - Institute of Basic Medical Sciences, National Cheng Kung University College of 
      Medicine, Tainan, 70101, Taiwan, ROC. lungyu@mail.ncku.edu.tw.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20160310
PL  - Germany
TA  - Psychopharmacology (Berl)
JT  - Psychopharmacology
JID - 7608025
RN  - 0 (Acetophenones)
RN  - 0 (Benzopyrans)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Central Nervous System Stimulants)
RN  - 44RAL3456C (Methamphetamine)
RN  - E29LP3ZMUH (rottlerin)
RN  - EC 2.7.10.1 (Receptor, trkB)
RN  - I5Y540LHVR (Cocaine)
SB  - IM
MH  - Acetophenones/*pharmacology
MH  - Animals
MH  - Benzopyrans/*pharmacology
MH  - Brain-Derived Neurotrophic Factor/metabolism
MH  - Central Nervous System Stimulants/antagonists & inhibitors/*pharmacology
MH  - Cocaine/*pharmacology
MH  - Male
MH  - Memory/*drug effects/physiology
MH  - Methamphetamine/*pharmacology
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Receptor, trkB/metabolism
OTO - NOTNLM
OT  - BDNF
OT  - Cocaine
OT  - Conditioning
OT  - Drug memory
OT  - Methamphetamine
OT  - Rottlerin
EDAT- 2016/03/11 06:00
MHDA- 2016/12/15 06:00
CRDT- 2016/03/11 06:00
PHST- 2015/09/14 00:00 [received]
PHST- 2016/02/07 00:00 [accepted]
PHST- 2016/03/11 06:00 [entrez]
PHST- 2016/03/11 06:00 [pubmed]
PHST- 2016/12/15 06:00 [medline]
AID - 10.1007/s00213-016-4251-8 [pii]
AID - 10.1007/s00213-016-4251-8 [doi]
PST - ppublish
SO  - Psychopharmacology (Berl). 2016 Apr;233(8):1455-65. doi: 
      10.1007/s00213-016-4251-8. Epub 2016 Mar 10.