PMID- 26961224 OWN - NLM STAT- MEDLINE DCOM- 20160919 LR - 20240324 IS - 1472-6882 (Electronic) IS - 1472-6882 (Linking) VI - 16 DP - 2016 Mar 9 TI - Combination with Red ginseng and Polygoni Multiflori ameliorates highfructose diet induced metabolic syndrome. PG - 98 LID - 10.1186/s12906-016-1063-7 [doi] LID - 98 AB - BACKGROUND: Metabolic syndrome such as dyslipidemia, hypertension, obesity, impaired glucose tolerance and fatty liver, can be caused by modification of diet by means of overconsumption of high fructose diet. This study was designed to investigate whether combination with Red ginseng and Polygoni Multiflori Radix (RGPM), widely used traditional herbal medicine, ameliorates on highfructose (HF) diet-induced metabolic syndrome. METHODS: SD rats were fed the 60% HF diet with/without rosiglitazone, and RGPM 100, 300 mg/kg/day, respectively. All groups received regular diet or HF diet, respectively, for 8 weeks. The last three groups treatment of rosiglitazone and RPGM orally for a period of 6 weeks. RESULTS: Chronic treatment with RGPM significantly decreased body weight, fat weight and adipocyte size. RGPM significantly prevented the development of the metabolic disturbances such as hypertension, hyperlipidemia and impaired glucose tolerance. RGPM also led to increase in high density lipoprotein level in the HF group. RGPM suppressed high-fructose diet induced vascular inflammation marker expression such as adhesion molecules and ET-1 in aorta as well as increasing of C-reactive protein (CRP) levels in plasma. Similarly, RGPM attenuated hepatic lipid accumulation by inhibition of monocyte chemoattractant protein-1 (MCP-1) expression. CONCLUSION: An administration of RGPM may be a beneficial therapy for the treatment of metabolic syndrome through the improvement of hypertension, obesity, hyperlipidemia, vascular inflammation and insulin resistance. FAU - Kho, Min Chul AU - Kho MC AD - College of Oriental Medicine and Professional Graduate School of Oriental Medicine, Wonkwang University, Shinyong-dong, Iksan, Jeonbuk, 570-749, Korea. AD - Hanbang Body-fluid Research Center, Wonkwang University, Shinyong-dong, Iksan, Jeonbuk, 570-749, Korea. FAU - Lee, Yun Jung AU - Lee YJ AD - College of Oriental Medicine and Professional Graduate School of Oriental Medicine, Wonkwang University, Shinyong-dong, Iksan, Jeonbuk, 570-749, Korea. AD - Hanbang Body-fluid Research Center, Wonkwang University, Shinyong-dong, Iksan, Jeonbuk, 570-749, Korea. FAU - Park, Ji Hun AU - Park JH AD - Hanbang Body-fluid Research Center, Wonkwang University, Shinyong-dong, Iksan, Jeonbuk, 570-749, Korea. FAU - Cha, Jeong Dan AU - Cha JD AD - Department of Research Development, Institute of Jinan Red Ginseng, Jinan, Korea. FAU - Choi, Kyung Min AU - Choi KM AD - Department of Research Development, Institute of Jinan Red Ginseng, Jinan, Korea. FAU - Kang, Dae Gill AU - Kang DG AD - College of Oriental Medicine and Professional Graduate School of Oriental Medicine, Wonkwang University, Shinyong-dong, Iksan, Jeonbuk, 570-749, Korea. dgkang@wku.ac.kr. AD - Hanbang Body-fluid Research Center, Wonkwang University, Shinyong-dong, Iksan, Jeonbuk, 570-749, Korea. dgkang@wku.ac.kr. AD - Brain Korea (BK)21 plus team, Professional Graduate School of Oriental Medicine, Wonkwang University, Iksan, Jeonbuk, 540-749, Republic of Korea. dgkang@wku.ac.kr. FAU - Lee, Ho Sub AU - Lee HS AD - College of Oriental Medicine and Professional Graduate School of Oriental Medicine, Wonkwang University, Shinyong-dong, Iksan, Jeonbuk, 570-749, Korea. host@wku.ac.kr. AD - Hanbang Body-fluid Research Center, Wonkwang University, Shinyong-dong, Iksan, Jeonbuk, 570-749, Korea. host@wku.ac.kr. AD - Brain Korea (BK)21 plus team, Professional Graduate School of Oriental Medicine, Wonkwang University, Iksan, Jeonbuk, 540-749, Republic of Korea. host@wku.ac.kr. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20160309 PL - England TA - BMC Complement Altern Med JT - BMC complementary and alternative medicine JID - 101088661 RN - 0 (Blood Glucose) RN - 0 (Chemokine CCL2) RN - 0 (Drugs, Chinese Herbal) RN - 0 (Inflammation Mediators) RN - 0 (Lipoproteins, HDL) RN - 30237-26-4 (Fructose) RN - 9007-41-4 (C-Reactive Protein) SB - IM MH - Adipose Tissue/metabolism MH - Animals MH - Blood Glucose/metabolism MH - Blood Pressure MH - Body Composition/drug effects MH - Body Weight/drug effects MH - C-Reactive Protein/metabolism MH - Chemokine CCL2/blood MH - Diet/adverse effects MH - Drug Therapy, Combination MH - Drugs, Chinese Herbal/pharmacology/*therapeutic use MH - Fructose/*administration & dosage/adverse effects MH - Inflammation Mediators/metabolism MH - Lipoproteins, HDL/blood MH - Male MH - Metabolic Syndrome/*drug therapy/etiology/metabolism MH - Obesity/complications/*drug therapy/metabolism MH - *Panax MH - *Phytotherapy MH - *Polygonum MH - Rats, Sprague-Dawley PMC - PMC4784406 EDAT- 2016/03/11 06:00 MHDA- 2016/09/20 06:00 PMCR- 2016/03/09 CRDT- 2016/03/11 06:00 PHST- 2015/11/11 00:00 [received] PHST- 2016/02/19 00:00 [accepted] PHST- 2016/03/11 06:00 [entrez] PHST- 2016/03/11 06:00 [pubmed] PHST- 2016/09/20 06:00 [medline] PHST- 2016/03/09 00:00 [pmc-release] AID - 10.1186/s12906-016-1063-7 [pii] AID - 1063 [pii] AID - 10.1186/s12906-016-1063-7 [doi] PST - epublish SO - BMC Complement Altern Med. 2016 Mar 9;16:98. doi: 10.1186/s12906-016-1063-7.