PMID- 26962178
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230217
IS  - 1541-6100 (Electronic)
IS  - 0022-3166 (Print)
IS  - 0022-3166 (Linking)
VI  - 146
IP  - 4
DP  - 2015 Apr 1
TI  - Protective Effects of the Mediterranean Diet on Type 2 Diabetes and Metabolic 
      Syndrome.
PG  - 920S-927S
LID - 10.3945/jn.115.218487 [doi]
AB  - Several studies provide evidence supporting a beneficial effect from the 
      traditional Mediterranean diet (MedDiet) on the risk of type 2 diabetes mellitus 
      (T2DM) and metabolic syndrome (MetS). This review summarizes the current 
      scientific evidence from epidemiologic studies and clinical trials on the 
      relation between the MedDiet and T2DM and MetS and the possible mechanisms 
      underlying the reported associations. A recent meta-analysis of prospective 
      cohort studies showed that greater adherence to the MedDiet was associated with a 
      significant reduction in the risk of diabetes. The MedDiet has also been found to 
      be beneficial in the prevention of gestational diabetes. Four large prospective 
      studies have observed inverse associations between the MedDiet and MetS or its 
      components. Few randomized controlled trials (RCTs) have evaluated the effect of 
      the MedDiet on T2DM and MetS. Results from the landmark PREvencion con DIeta 
      MEDiterranea (PREDIMED) nutrition intervention trial showed that participants 
      assigned to the MedDiet had a significant 30% reduction in the risk of T2DM and 
      that it also promoted the reversion of MetS and its components, hyperglycemia and 
      central obesity. In addition, 5 RCTs showed the beneficial effects of the MedDiet 
      compared with other dietary patterns on glycemic control in patients with T2DM. A 
      recent meta-analysis of RCTs revealed that, compared with a variety of control 
      diets, the MedDiet was associated with beneficial effects on all MetS components. 
      Bioactive components of the MedDiet synergize to affect various metabolic 
      pathways, leading to a reduced cardiometabolic disease risk. The abundance of 
      healthy, nutrient-dense foods that make up the plant-based MedDiet predicts its 
      bioactivity and potential to beneficially influence metabolic pathways that lead 
      to MetS and T2DM, as well as other chronic conditions. Abundant epidemiologic and 
      clinical trial evidence supports the role of the MedDiet on the prevention and 
      management of T2DM and MetS.
CI  - (c) 2016 American Society for Nutrition.
FAU - Salas-Salvado, Jordi
AU  - Salas-Salvado J
AD  - Human Nutrition Unit, University Hospital of Sant Joan de Reus, Department of 
      Biochemistry and Biotechnology, Faculty of Medicine and Health Sciences, Pere 
      Virgili Health Research Center, Rovira i Virgili University, Reus, Spain.
AD  - Biomedical Research Centre in Physiopathology of Obesity and Nutrition, Carlos 
      III Health Institute, Madrid, Spain.
FAU - Guasch-Ferre, Marta
AU  - Guasch-Ferre M
AD  - Human Nutrition Unit, University Hospital of Sant Joan de Reus, Department of 
      Biochemistry and Biotechnology, Faculty of Medicine and Health Sciences, Pere 
      Virgili Health Research Center, Rovira i Virgili University, Reus, Spain.
AD  - Biomedical Research Centre in Physiopathology of Obesity and Nutrition, Carlos 
      III Health Institute, Madrid, Spain.
FAU - Lee, Chih-Hao
AU  - Lee CH
AD  - Department of Genetics and Complex Diseases, Division of Biological Sciences, 
      Harvard T.H. Chan School of Public Health, Boston, MA.
FAU - Estruch, Ramon
AU  - Estruch R
AD  - Biomedical Research Centre in Physiopathology of Obesity and Nutrition, Carlos 
      III Health Institute, Madrid, Spain.
AD  - Department of Internal Medicine, August Pi i Sunyer Biomedical Research 
      Institute, Hospital Clinic, University of Barcelona, Barcelona, Spain.
FAU - Clish, Clary B
AU  - Clish CB
AD  - Broad Institute of MIT and Harvard, Cambridge, MA.
FAU - Ros, Emilio
AU  - Ros E
AD  - Biomedical Research Centre in Physiopathology of Obesity and Nutrition, Carlos 
      III Health Institute, Madrid, Spain.
AD  - Lipid Clinic, Endocrinology and Nutrition Service, August Pi i Sunyer Biomedical 
      Research Institute, Hospital Clinic, University of Barcelona, Barcelona, Spain.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Nutr
JT  - The Journal of nutrition
JID - 0404243
SB  - IM
PMC - PMC4807638
OTO - NOTNLM
OT  - Mediterranean diet
OT  - cardiovascular disease
OT  - diabetes
OT  - metabolic syndrome
OT  - metabolic syndrome components
OT  - review
COIS- Author disclosures: JS-S has received grants from the International Nut and Dried 
      Fruit Foundation and is a nonpaid member of the scientific advisory board of the 
      International Nut and Dried Fruit Foundation. ER has received grants from the 
      California Walnut Commission and is a nonpaid member of its scientific advisory 
      committee. MG-F, C-HL, RE, and CBC, no conflicts of interest.
EDAT- 2016/03/11 06:00
MHDA- 2016/03/11 06:01
PMCR- 2017/04/01
CRDT- 2016/03/11 06:00
PHST- 2015/06/12 00:00 [received]
PHST- 2015/07/27 00:00 [revised]
PHST- 2015/09/18 00:00 [accepted]
PHST- 2016/03/11 06:00 [pubmed]
PHST- 2016/03/11 06:01 [medline]
PHST- 2016/03/11 06:00 [entrez]
PHST- 2017/04/01 00:00 [pmc-release]
AID - S0022-3166(23)00589-8 [pii]
AID - 218487 [pii]
AID - 10.3945/jn.115.218487 [doi]
PST - ppublish
SO  - J Nutr. 2015 Apr 1;146(4):920S-927S. doi: 10.3945/jn.115.218487.