PMID- 26965439
OWN - NLM
STAT- MEDLINE
DCOM- 20171023
LR  - 20220316
IS  - 1532-2092 (Electronic)
IS  - 1099-5129 (Print)
IS  - 1099-5129 (Linking)
VI  - 19
IP  - 3
DP  - 2017 Mar 1
TI  - Clinical predictors of cardiac magnetic resonance late gadolinium enhancement in 
      patients with atrial fibrillation.
PG  - 371-377
LID - 10.1093/europace/euw019 [doi]
AB  - AIMS: This study aims to examine the association of clinical co-morbidities with 
      the presence of left atrial (LA) late gadolinium enhancement (LGE) on cardiac 
      magnetic resonance (CMR). Previous studies have established the severity of LA 
      LGE to be associated with atrial fibrillation (AF) recurrence following AF 
      ablation. We sought to determine whether baseline clinical characteristics were 
      associated with LGE extent among patients presenting for an initial AF ablation. 
      METHODS AND RESULTS: The cohort consisted of 179 consecutive patients with no 
      prior cardiac ablation procedures who underwent pre-procedure LGE-CMR. The extent 
      of LA LGE for each patient was calculated using the image intensity ratio, 
      normalized to the mean blood pool intensity, corresponding to a bipolar voltage 
      </=0.3 mV. The association of LGE extent with baseline clinical characteristics was 
      examined using non-parametric and multivariable models. The mean age of the 
      cohort was 60.9 +/- 9.6 years and 128 (72%) were male. In total, 56 (31%) patients 
      had persistent AF. The mean LA volume was 118.4 +/- 41.6 mL, and the mean LA LGE 
      extent was 14.1 +/- 10.4%. There was no association with any clinical variables 
      with LGE extent by quartiles in the multivariable model. Extent of LGE as a 
      continuous variable was positively, but weakly associated with LA volume in a 
      multivariable model adjusting for age, body mass index, AF persistence, and left 
      ventricular ejection fraction (1.5% scar/mL, P = 0.038). CONCLUSION: In a cohort 
      of patients presenting for initial AF ablation, the presence of pre-ablation LA 
      LGE extent was weakly, but positively associated with increasing LA volume.
CI  - Published on behalf of the European Society of Cardiology. All rights reserved. (c) 
      The Author 2016. For permissions please email: journals.permissions@oup.com.
FAU - Chrispin, Jonathan
AU  - Chrispin J
AD  - Department of Cardiology, Johns Hopkins University School of Medicine, 1800 
      Orleans Street, Zayed 7125, Baltimore, MD 21287, USA.
FAU - Ipek, Esra Gucuk
AU  - Ipek EG
AD  - Department of Cardiology, Johns Hopkins University School of Medicine, 1800 
      Orleans Street, Zayed 7125, Baltimore, MD 21287, USA.
FAU - Habibi, Mohammadali
AU  - Habibi M
AD  - Department of Cardiology, Johns Hopkins University School of Medicine, 1800 
      Orleans Street, Zayed 7125, Baltimore, MD 21287, USA.
FAU - Yang, Eunice
AU  - Yang E
AD  - Department of Cardiology, Johns Hopkins University School of Medicine, 1800 
      Orleans Street, Zayed 7125, Baltimore, MD 21287, USA.
FAU - Spragg, David
AU  - Spragg D
AD  - Department of Cardiology, Johns Hopkins University School of Medicine, 1800 
      Orleans Street, Zayed 7125, Baltimore, MD 21287, USA.
FAU - Marine, Joseph E
AU  - Marine JE
AD  - Department of Cardiology, Johns Hopkins University School of Medicine, 1800 
      Orleans Street, Zayed 7125, Baltimore, MD 21287, USA.
FAU - Ashikaga, Hiroshi
AU  - Ashikaga H
AD  - Department of Cardiology, Johns Hopkins University School of Medicine, 1800 
      Orleans Street, Zayed 7125, Baltimore, MD 21287, USA.
AD  - Department of Biomedical Engineering, Johns Hopkins University School of 
      Medicine, Baltimore, MD, USA.
FAU - Rickard, John
AU  - Rickard J
AD  - Department of Cardiology, Johns Hopkins University School of Medicine, 1800 
      Orleans Street, Zayed 7125, Baltimore, MD 21287, USA.
FAU - Berger, Ronald D
AU  - Berger RD
AD  - Department of Cardiology, Johns Hopkins University School of Medicine, 1800 
      Orleans Street, Zayed 7125, Baltimore, MD 21287, USA.
AD  - Department of Biomedical Engineering, Johns Hopkins University School of 
      Medicine, Baltimore, MD, USA.
FAU - Zimmerman, Stefan L
AU  - Zimmerman SL
AD  - Department of Radiology and Radiological Sciences, Johns Hopkins University 
      School of Medicine, Baltimore, MD, USA.
FAU - Calkins, Hugh
AU  - Calkins H
AD  - Department of Cardiology, Johns Hopkins University School of Medicine, 1800 
      Orleans Street, Zayed 7125, Baltimore, MD 21287, USA.
FAU - Nazarian, Saman
AU  - Nazarian S
AD  - Department of Cardiology, Johns Hopkins University School of Medicine, 1800 
      Orleans Street, Zayed 7125, Baltimore, MD 21287, USA.
AD  - Department of Epidemiology, Johns Hopkins University School of Medicine, 
      Baltimore, MD, USA.
LA  - eng
PT  - Journal Article
PL  - England
TA  - Europace
JT  - Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal 
      of the working groups on cardiac pacing, arrhythmias, and cardiac cellular 
      electrophysiology of the European Society of Cardiology
JID - 100883649
RN  - 0 (Contrast Media)
RN  - K2I13DR72L (Gadolinium DTPA)
SB  - IM
MH  - Aged
MH  - Atrial Fibrillation/*diagnostic imaging/physiopathology/surgery
MH  - Atrial Function, Left
MH  - Atrial Remodeling
MH  - Catheter Ablation
MH  - Contrast Media/*administration & dosage
MH  - Female
MH  - Fibrosis
MH  - Gadolinium DTPA/*administration & dosage
MH  - Heart Atria/*diagnostic imaging/physiopathology/surgery
MH  - Humans
MH  - Linear Models
MH  - Logistic Models
MH  - *Magnetic Resonance Imaging
MH  - Male
MH  - Middle Aged
MH  - Multivariate Analysis
MH  - Odds Ratio
MH  - Predictive Value of Tests
MH  - Prospective Studies
MH  - Registries
MH  - Risk Factors
MH  - Stroke Volume
MH  - Ventricular Function, Left
PMC - PMC5834111
OTO - NOTNLM
OT  - Ablation
OT  - Atrial fibrillation
OT  - Cardiac magnetic resonance imaging
OT  - Delayed enhancement magnetic resonance
OT  - Fibrosis
EDAT- 2016/03/12 06:00
MHDA- 2017/10/24 06:00
PMCR- 2018/03/01
CRDT- 2016/03/12 06:00
PHST- 2015/10/19 00:00 [received]
PHST- 2016/01/18 00:00 [accepted]
PHST- 2016/03/12 06:00 [pubmed]
PHST- 2017/10/24 06:00 [medline]
PHST- 2016/03/12 06:00 [entrez]
PHST- 2018/03/01 00:00 [pmc-release]
AID - euw019 [pii]
AID - 10.1093/europace/euw019 [doi]
PST - ppublish
SO  - Europace. 2017 Mar 1;19(3):371-377. doi: 10.1093/europace/euw019.