PMID- 26966693
OWN - NLM
STAT- MEDLINE
DCOM- 20161101
LR  - 20201226
IS  - 2314-7156 (Electronic)
IS  - 2314-8861 (Print)
IS  - 2314-7156 (Linking)
VI  - 2016
DP  - 2016
TI  - Dendritic Cells under Hypoxia: How Oxygen Shortage Affects the Linkage between 
      Innate and Adaptive Immunity.
PG  - 5134329
LID - 10.1155/2016/5134329 [doi]
LID - 5134329
AB  - Dendritic cells (DCs) are considered as one of the main regulators of immune 
      responses. They collect antigens, process them, and present typical antigenic 
      structures to lymphocytes, thereby inducing an adaptive immune response. All 
      these processes take place under conditions of oxygen shortage (hypoxia) which is 
      often not considered in experimental settings. This review highlights how deeply 
      hypoxia modulates human as well as mouse immature and mature dendritic cell 
      functions. It tries to link in vitro results to actual in vivo studies and 
      outlines how hypoxia-mediated shaping of dendritic cells affects the activation 
      of (innate) immunity.
FAU - Winning, Sandra
AU  - Winning S
AD  - Institut fur Physiologie, Universitat Duisburg-Essen, Hufelandstrasse 55, 45122 
      Essen, Germany.
FAU - Fandrey, Joachim
AU  - Fandrey J
AD  - Institut fur Physiologie, Universitat Duisburg-Essen, Hufelandstrasse 55, 45122 
      Essen, Germany.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20160204
PL  - Egypt
TA  - J Immunol Res
JT  - Journal of immunology research
JID - 101627166
RN  - 0 (Antigens)
RN  - 0 (Cytokines)
RN  - S88TT14065 (Oxygen)
SB  - IM
MH  - Adaptive Immunity/*drug effects
MH  - Animals
MH  - Antigen Presentation/drug effects
MH  - Antigens/immunology
MH  - Cytokines/genetics/immunology
MH  - Dendritic Cells/*drug effects/immunology/pathology
MH  - Gene Expression Regulation
MH  - Humans
MH  - Hypoxia/*immunology/pathology
MH  - Immunity, Innate/*drug effects
MH  - Inflammation
MH  - Lymphocytes/drug effects/immunology/pathology
MH  - Mice
MH  - Oxygen/*pharmacology
MH  - Signal Transduction
PMC - PMC4757696
EDAT- 2016/03/12 06:00
MHDA- 2016/11/02 06:00
PMCR- 2016/02/04
CRDT- 2016/03/12 06:00
PHST- 2015/11/09 00:00 [received]
PHST- 2016/01/07 00:00 [revised]
PHST- 2016/01/13 00:00 [accepted]
PHST- 2016/03/12 06:00 [entrez]
PHST- 2016/03/12 06:00 [pubmed]
PHST- 2016/11/02 06:00 [medline]
PHST- 2016/02/04 00:00 [pmc-release]
AID - 10.1155/2016/5134329 [doi]
PST - ppublish
SO  - J Immunol Res. 2016;2016:5134329. doi: 10.1155/2016/5134329. Epub 2016 Feb 4.