PMID- 26967713
OWN - NLM
STAT- MEDLINE
DCOM- 20170208
LR  - 20170208
IS  - 1651-226X (Electronic)
IS  - 0284-186X (Linking)
VI  - 55
IP  - 5
DP  - 2016 May
TI  - Young patients with hematologic and lymphatic malignancies have an increased risk 
      of hip and knee arthroplasty.
PG  - 567-71
LID - 10.3109/0284186X.2015.1119884 [doi]
AB  - Background Skeletal complications such as osteonecrosis (ON) are potential 
      adverse events in patients treated for cancer, especially in those treated for 
      hematologic and lymphatic malignancies (HLMs). ON may damage the hip or knee 
      joints and may lead to arthrosis requiring total joint arthroplasty (TJA). The 
      aim of this study was to address the risk of TJA in patients with cancer, 
      especially those treated for HLM, in a nationwide population-based setting. 
      Material and methods All patients who had undergone TJA after cancer diagnosis 
      between the years 2000 and 2012 were identified by linking the Arthroplasty 
      Register and the Cancer Registry. Standardized incidence ratios (SIRs) of TJAs 
      were calculated to assess whether patients with any cancer, but especially HLM, 
      have increased risk for TJA when compared with the general population. Results In 
      patients with HLM or other cancer, the overall SIRs were similar compared with 
      the general population. However, in HLM patients under 50 years of age, the SIR 
      was 7.6, and in patients under 35 years of age, it was 45.5. The corresponding 
      SIRs in patients with other cancers were 3.6 and 6.6, respectively. The highest 
      SIRs, including all age groups, were among patients with acute lymphoblastic 
      leukemia (SIR = 4.5) and acute myeloid leukemia (SIR = 1.9). Discussion HLMs 
      imply an increased risk for TJA compared with the general population. The risk is 
      especially high in patients younger than 50 years, regardless of the type of HLM. 
      Young patients with HLM, as well as their healthcare providers, should be aware 
      of the highly increased risk of skeletal complications requiring TJA.
FAU - Niinimaki, Tuukka T
AU  - Niinimaki TT
AD  - a Department of Surgery , Oulu University Hospital and University of Oulu , Oulu 
      , Finland ;
FAU - Ohtonen, Pasi
AU  - Ohtonen P
AD  - b Division of Operative Care and Medical Research Center Oulu , Oulu University 
      Hospital and University of Oulu , Oulu , Finland ;
FAU - Harila-Saari, Arja H
AU  - Harila-Saari AH
AD  - c Department of Women's and Children's Health , Karolinska Institutet , Stockholm 
      , Sweden ;
FAU - Niinimaki, Riitta A
AU  - Niinimaki RA
AD  - d Department of Children and Adolescents , Oulu University Hospital and 
      University of Oulu , Oulu , Finland.
LA  - eng
PT  - Journal Article
DEP - 20160311
PL  - Sweden
TA  - Acta Oncol
JT  - Acta oncologica (Stockholm, Sweden)
JID - 8709065
RN  - 0 (Adrenal Cortex Hormones)
SB  - IM
MH  - Adolescent
MH  - Adrenal Cortex Hormones/adverse effects/therapeutic use
MH  - Adult
MH  - Age Factors
MH  - Aged
MH  - Aged, 80 and over
MH  - Arthroplasty, Replacement, Hip/*statistics & numerical data
MH  - Arthroplasty, Replacement, Knee/*statistics & numerical data
MH  - Child
MH  - Female
MH  - Finland/epidemiology
MH  - Hematologic Neoplasms/complications/*epidemiology/therapy
MH  - Hematopoietic Stem Cell Transplantation/adverse effects
MH  - Hip Joint/pathology/surgery
MH  - Humans
MH  - Incidence
MH  - Knee Joint/pathology/surgery
MH  - Male
MH  - Middle Aged
MH  - Osteonecrosis/*epidemiology/etiology/surgery
MH  - Risk
MH  - Young Adult
EDAT- 2016/03/12 06:00
MHDA- 2017/02/09 06:00
CRDT- 2016/03/12 06:00
PHST- 2016/03/12 06:00 [entrez]
PHST- 2016/03/12 06:00 [pubmed]
PHST- 2017/02/09 06:00 [medline]
AID - 10.3109/0284186X.2015.1119884 [doi]
PST - ppublish
SO  - Acta Oncol. 2016 May;55(5):567-71. doi: 10.3109/0284186X.2015.1119884. Epub 2016 
      Mar 11.