PMID- 26968381
OWN - NLM
STAT- MEDLINE
DCOM- 20161013
LR  - 20181113
IS  - 1476-069X (Electronic)
IS  - 1476-069X (Linking)
VI  - 15
DP  - 2016 Mar 12
TI  - Neurodevelopmental outcomes among 2- to 3-year-old children in Bangladesh with 
      elevated blood lead and exposure to arsenic and manganese in drinking water.
PG  - 44
LID - 10.1186/s12940-016-0127-y [doi]
LID - 44
AB  - BACKGROUND: The people of Bangladesh are currently exposed to high concentrations 
      of arsenic and manganese in drinking water, as well as elevated lead in many 
      regions. The objective of this study was to investigate associations between 
      environmental exposure to these contaminants and neurodevelopmental outcomes 
      among Bangladeshi children. METHODS: We evaluated data from 524 children, members 
      of an ongoing prospective birth cohort established to study the effects of 
      prenatal and early childhood arsenic exposure in the Sirajdikhan and Pabna 
      Districts of Bangladesh. Water was collected from the family's primary drinking 
      source during the first trimester of pregnancy and at ages 1, 12 and 20-40 
      months. At age 20-40 months, blood lead was measured and neurodevelopmental 
      outcomes were assessed using a translated, culturally-adapted version of the 
      Bayley Scales of Infant and Toddler Development, Third Edition (BSID-III). 
      RESULTS: Median blood lead concentrations were higher in Sirajdikhan than Pabna 
      (7.6 vs. <LODmug/dL, p <0.0001) and water arsenic concentrations were lower (1.5 
      vs 25.7 mug/L, p <0.0001). Increased blood lead was associated with decreased 
      cognitive scores in Sirajdikhan (beta = -0.17, SE = 0.09, p = 0.05), whereas 
      increased water arsenic was associated with decreased cognitive scores in Pabna 
      (beta = -0.06, SE = 0.03, p = 0.05). Water manganese was associated with fine motor 
      scores in an inverse-U relationship in Pabna. CONCLUSION: Where blood lead levels 
      are high, lead is associated with decreased cognitive scores on the BSID-III, and 
      effects of other metals are not detected. In the setting of lower lead levels, 
      the adverse effects of arsenic and manganese on neurodevelopment are observed.
FAU - Rodrigues, Ema G
AU  - Rodrigues EG
AD  - Department of Neurology, Boston Children's Hospital, Boston, MA, USA. 
      Ema.Rodrigues@childrens.harvard.edu.
AD  - Department of Environmental Health, Harvard T.H. Chan School of Public Health, 
      Boston, MA, USA. Ema.Rodrigues@childrens.harvard.edu.
AD  - Department of Neurology, Harvard Medical School, Boston, MA, USA. 
      Ema.Rodrigues@childrens.harvard.edu.
FAU - Bellinger, David C
AU  - Bellinger DC
AD  - Department of Neurology, Boston Children's Hospital, Boston, MA, USA.
AD  - Department of Environmental Health, Harvard T.H. Chan School of Public Health, 
      Boston, MA, USA.
AD  - Department of Neurology, Harvard Medical School, Boston, MA, USA.
FAU - Valeri, Linda
AU  - Valeri L
AD  - Department of Psychiatry (Biostatistics), McLean Hospital, Belmont, MA, USA.
AD  - Department of Psychiatry, Harvard Medical School, Boston, MA, USA.
FAU - Hasan, Md Omar Sharif Ibne
AU  - Hasan MO
AD  - Dhaka Community Hospital, Dhaka, Bangladesh.
FAU - Quamruzzaman, Quazi
AU  - Quamruzzaman Q
AD  - Dhaka Community Hospital, Dhaka, Bangladesh.
FAU - Golam, Mostofa
AU  - Golam M
AD  - Dhaka Community Hospital, Dhaka, Bangladesh.
FAU - Kile, Molly L
AU  - Kile ML
AD  - Department of Public Health, Oregon State University, Corvallis, OR, USA.
FAU - Christiani, David C
AU  - Christiani DC
AD  - Department of Environmental Health, Harvard T.H. Chan School of Public Health, 
      Boston, MA, USA.
FAU - Wright, Robert O
AU  - Wright RO
AD  - Department of Preventive Medicine, Mount Sinai School of Medicine, New York, NY, 
      USA.
FAU - Mazumdar, Maitreyi
AU  - Mazumdar M
AD  - Department of Neurology, Boston Children's Hospital, Boston, MA, USA.
AD  - Department of Environmental Health, Harvard T.H. Chan School of Public Health, 
      Boston, MA, USA.
AD  - Department of Neurology, Harvard Medical School, Boston, MA, USA.
LA  - eng
GR  - P30 ES000002/ES/NIEHS NIH HHS/United States
GR  - P30 ES023515/ES/NIEHS NIH HHS/United States
GR  - ES P42 ES016454/ES/NIEHS NIH HHS/United States
GR  - U54 HD090255/HD/NICHD NIH HHS/United States
GR  - K23 ES017437/ES/NIEHS NIH HHS/United States
GR  - P42 ES016454/ES/NIEHS NIH HHS/United States
GR  - R01 ES011622/ES/NIEHS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20160312
PL  - England
TA  - Environ Health
JT  - Environmental health : a global access science source
JID - 101147645
RN  - 0 (Drinking Water)
RN  - 0 (Environmental Pollutants)
RN  - 2P299V784P (Lead)
RN  - 42Z2K6ZL8P (Manganese)
RN  - N712M78A8G (Arsenic)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Arsenic/analysis/*toxicity
MH  - Bangladesh/epidemiology
MH  - Child Development/drug effects
MH  - Child, Preschool
MH  - Cognition/*drug effects
MH  - Drinking Water/analysis
MH  - Environmental Exposure/adverse effects
MH  - Environmental Pollutants/analysis/*toxicity
MH  - Female
MH  - Humans
MH  - Infant
MH  - Lead/blood/*toxicity
MH  - Male
MH  - Manganese/analysis/*toxicity
MH  - Neurodevelopmental Disorders/*chemically induced/epidemiology
MH  - Pregnancy
MH  - Pregnancy Trimester, First
MH  - Young Adult
PMC - PMC4788832
OTO - NOTNLM
OT  - Arsenic
OT  - Cognitive function
OT  - Lead
OT  - Manganese
EDAT- 2016/03/13 06:00
MHDA- 2016/10/14 06:00
PMCR- 2016/03/12
CRDT- 2016/03/13 06:00
PHST- 2015/11/17 00:00 [received]
PHST- 2016/03/07 00:00 [accepted]
PHST- 2016/03/13 06:00 [entrez]
PHST- 2016/03/13 06:00 [pubmed]
PHST- 2016/10/14 06:00 [medline]
PHST- 2016/03/12 00:00 [pmc-release]
AID - 10.1186/s12940-016-0127-y [pii]
AID - 127 [pii]
AID - 10.1186/s12940-016-0127-y [doi]
PST - epublish
SO  - Environ Health. 2016 Mar 12;15:44. doi: 10.1186/s12940-016-0127-y.