PMID- 26968847
OWN - NLM
STAT- MEDLINE
DCOM- 20170310
LR  - 20181113
IS  - 1600-0560 (Electronic)
IS  - 0303-6987 (Print)
IS  - 0303-6987 (Linking)
VI  - 43
IP  - 6
DP  - 2016 Jun
TI  - The self-reported use of immunostains and cytogenetic testing in the diagnosis of 
      melanoma by practicing U.S. pathologists of 10 selected states.
PG  - 492-7
LID - 10.1111/cup.12705 [doi]
AB  - BACKGROUNDS: The diagnosis of melanoma can be challenging, especially in lesions 
      for which the histopathologic criteria bridge two or more taxonomic categories. 
      Newer genomic analytical methods of fluorescence in situ hybridization (FISH) and 
      comparative genomic hybridization (CGH) have been introduced as ancillary 
      techniques to differentiate benign and malignant melanocytic proliferations. 
      METHODS: We evaluated how pathologists perceive and are incorporating these new 
      cytogenetic testing technologies into their practices. We conducted a study of 
      207 U.S. pathologists who interpret melanocytic lesions in clinical practice in 
      10 SEER states. Pathologists were surveyed regarding perceptions and utilization 
      of FISH and/or CGH in their clinical practices. RESULTS: Results showed that 38% 
      of pathologists use FISH and/or CGH in interpreting melanocytic lesions. 
      Pathologists reporting FISH and/or CGH use were significantly younger (p < 0.05), 
      were fellowship trained or board certified in dermatopathology (p < 0.001) and 
      were affiliated with an academic institute (p < 0.001). Pathologists reporting 
      that their colleagues consider them an expert in the assessment of melanocytic 
      lesions were more likely to employ FISH and/or CGH in their practices than 
      non-experts. CONCLUSIONS: Early users of cytogenetic testing technologies in 
      cutaneous pathology are more likely to be younger, affiliated with an academic 
      institution and fellowship trained or board certified in dermatopathology.
CI  - (c) 2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
FAU - Zhao, Ge
AU  - Zhao G
AD  - Division of Dermatology, Department of Medicine, University of Washington School 
      of Medicine, Seattle, WA, USA.
FAU - Lee, Kachiu C
AU  - Lee KC
AD  - Department of Dermatology, Massachusetts General Hospital, Harvard University, 
      Boston, MA, USA.
FAU - Kwon, Gina
AU  - Kwon G
AD  - Division of Dermatology, Department of Medicine, University of Washington School 
      of Medicine, Seattle, WA, USA.
FAU - Frederick, Paul D
AU  - Frederick PD
AD  - Department of Medicine, University of Washington School of Medicine, Seattle, WA, 
      USA.
FAU - Onega, Tracy L
AU  - Onega TL
AD  - Department of Biomedical Data Science, Norris Cotton Cancer Center, Lebanon, NH, 
      USA.
AD  - Department of Epidemiology, Norris Cotton Cancer Center, Lebanon, NH, USA.
AD  - Department of Community and Family Medicine, Geisel School of Medicine at 
      Dartmouth, The Dartmouth Institute for Health Policy and Clinical Practice, 
      Lebanon, NH, USA.
FAU - Piepkorn, Michael W
AU  - Piepkorn MW
AD  - Division of Dermatology, Department of Medicine, University of Washington School 
      of Medicine, Seattle, WA, USA.
AD  - Dermatopathology Northwest, Bellevue, WA, USA.
FAU - Knezevich, Stevan
AU  - Knezevich S
AD  - Pathology Associates, Clovis, CA, USA.
FAU - Barnhill, Raymond L
AU  - Barnhill RL
AD  - Department of Pathology, Faculty of Medicine, University of Paris Descartes, 
      Paris, France.
AD  - Institut Curie, Paris, France.
FAU - Elder, David E
AU  - Elder DE
AD  - Department of Pathology, University of Pennsylvania, Philadelphia, PA, USA.
FAU - Elmore, Joann G
AU  - Elmore JG
AD  - Department of Medicine, University of Washington School of Medicine, Seattle, WA, 
      USA.
LA  - eng
GR  - K05 CA104699/CA/NCI NIH HHS/United States
GR  - R01 CA151306/CA/NCI NIH HHS/United States
GR  - T32 AR056969/AR/NIAMS NIH HHS/United States
PT  - Clinical Trial
PT  - Journal Article
PT  - Multicenter Study
DEP - 20160407
PL  - United States
TA  - J Cutan Pathol
JT  - Journal of cutaneous pathology
JID - 0425124
RN  - 0 (Immunosuppressive Agents)
SB  - IM
CIN - J Cutan Pathol. 2017 Jun;44(6):599-600. PMID: 28393383
MH  - Adult
MH  - Aged
MH  - Female
MH  - Humans
MH  - Immunosuppressive Agents/*administration & dosage
MH  - *In Situ Hybridization, Fluorescence
MH  - Male
MH  - *Melanoma/diagnosis/drug therapy/pathology
MH  - Middle Aged
MH  - *Self Medication
MH  - *Self Report
MH  - United States
PMC - PMC5592970
MID - NIHMS900859
OTO - NOTNLM
OT  - CGH
OT  - FISH
OT  - dermatopathology
EDAT- 2016/03/13 06:00
MHDA- 2017/03/11 06:00
PMCR- 2017/09/11
CRDT- 2016/03/13 06:00
PHST- 2015/12/21 00:00 [received]
PHST- 2016/02/25 00:00 [revised]
PHST- 2016/03/05 00:00 [accepted]
PHST- 2016/03/13 06:00 [entrez]
PHST- 2016/03/13 06:00 [pubmed]
PHST- 2017/03/11 06:00 [medline]
PHST- 2017/09/11 00:00 [pmc-release]
AID - 10.1111/cup.12705 [doi]
PST - ppublish
SO  - J Cutan Pathol. 2016 Jun;43(6):492-7. doi: 10.1111/cup.12705. Epub 2016 Apr 7.