PMID- 26968992
OWN - NLM
STAT- MEDLINE
DCOM- 20180205
LR  - 20220410
IS  - 1615-2573 (Electronic)
IS  - 0910-8327 (Linking)
VI  - 31
IP  - 12
DP  - 2016 Dec
TI  - Impact of left ventricular systolic dysfunction on the outcomes of percutaneous 
      edge-to-edge mitral valve repair using MitraClip.
PG  - 1988-1996
AB  - Left ventricular systolic dysfunction (LVD) is associated with poor outcomes 
      after mitral regurgitation (MR) surgery. MitraClip (MC) is a novel treatment 
      option for MR patients with a high surgical risk. However, outcomes of LVD 
      patients underwent MC remain unclear. In total of 194 patients after MC 
      implantation, 75 patients (39 %) had severe LVD (LV ejection fraction </=30 %). 
      Patients with severe LVD were primarily male and also younger. Logistic 
      euroSCOREs were comparable between the two groups. Functional MR was more common 
      in patients with severe LVD, while New York Heart Association (NYHA) class was 
      similar between the two groups. N-terminal pro-B-type natriuretic peptide 
      (NT-proBNP) was significantly higher in patients with LVD. In addition to similar 
      improvements in MR severity, NYHA class, and NT-proBNP levels, the survival rates 
      were not different between patients with and without severe LVD. Among patients 
      with severe LVD, the long-term survival rates were significantly lower in 
      patients aged >/=75 years, those with NT-proBNP >5000 pg/mL, and those with atrial 
      fibrillation (AF). In conclusion, severe LVD was not associated with the 
      mortality after MC implantation. MC might be feasible and effective even in the 
      patients with severe MR and low LVEF. However, we need to carefully observe 
      severe LVD patients who are elderly, have a high NT-proBNP level, and have AF, as 
      these might be considered high-risk subjects.
FAU - Kaneko, Hidehiro
AU  - Kaneko H
AD  - Department of Cardiology, Heart Center Brandenburg, Bernau, Germany.
AD  - Department of Cardiology, Medical School Brandenburg, Ladeburger Strasse 17, 
      16321, Bernau, Germany.
FAU - Neuss, Michael
AU  - Neuss M
AD  - Department of Cardiology, Heart Center Brandenburg, Bernau, Germany.
AD  - Department of Cardiology, Medical School Brandenburg, Ladeburger Strasse 17, 
      16321, Bernau, Germany.
FAU - Schau, Thomas
AU  - Schau T
AD  - Department of Cardiology, Heart Center Brandenburg, Bernau, Germany.
AD  - Department of Cardiology, Medical School Brandenburg, Ladeburger Strasse 17, 
      16321, Bernau, Germany.
FAU - Weissenborn, Jens
AU  - Weissenborn J
AD  - Department of Cardiology, Heart Center Brandenburg, Bernau, Germany.
AD  - Department of Cardiology, Medical School Brandenburg, Ladeburger Strasse 17, 
      16321, Bernau, Germany.
FAU - Butter, Christian
AU  - Butter C
AD  - Department of Cardiology, Heart Center Brandenburg, Bernau, Germany. 
      c.butter@immanuel.de.
AD  - Department of Cardiology, Medical School Brandenburg, Ladeburger Strasse 17, 
      16321, Bernau, Germany. c.butter@immanuel.de.
LA  - eng
PT  - Journal Article
DEP - 20160311
PL  - Japan
TA  - Heart Vessels
JT  - Heart and vessels
JID - 8511258
RN  - 0 (Biomarkers)
RN  - 0 (Peptide Fragments)
RN  - 0 (pro-brain natriuretic peptide (1-76))
RN  - 114471-18-0 (Natriuretic Peptide, Brain)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Biomarkers/blood
MH  - Databases, Factual
MH  - Echocardiography, Transesophageal
MH  - Female
MH  - *Heart Valve Prosthesis
MH  - Heart Valve Prosthesis Implantation/adverse effects/*instrumentation/mortality
MH  - Humans
MH  - Kaplan-Meier Estimate
MH  - Male
MH  - Middle Aged
MH  - Mitral Valve/physiopathology/*surgery
MH  - Mitral Valve Insufficiency/complications/mortality/physiopathology/*surgery
MH  - Natriuretic Peptide, Brain/blood
MH  - Peptide Fragments/blood
MH  - Prosthesis Design
MH  - Retrospective Studies
MH  - Severity of Illness Index
MH  - Systole
MH  - Time Factors
MH  - Treatment Outcome
MH  - Ventricular Dysfunction, Left/*complications/mortality/physiopathology
MH  - *Ventricular Function, Left
OTO - NOTNLM
OT  - Left ventricular dysfunction
OT  - Left ventricular ejection fraction
OT  - MitraClip
OT  - Percutaneous edge-to-edge mitral valve repair
EDAT- 2016/03/13 06:00
MHDA- 2018/02/06 06:00
CRDT- 2016/03/13 06:00
PHST- 2015/12/01 00:00 [received]
PHST- 2016/02/19 00:00 [accepted]
PHST- 2016/03/13 06:00 [pubmed]
PHST- 2018/02/06 06:00 [medline]
PHST- 2016/03/13 06:00 [entrez]
AID - 10.1007/s00380-016-0822-1 [pii]
AID - 10.1007/s00380-016-0822-1 [doi]
PST - ppublish
SO  - Heart Vessels. 2016 Dec;31(12):1988-1996. doi: 10.1007/s00380-016-0822-1. Epub 
      2016 Mar 11.