PMID- 26969440
OWN - NLM
STAT- MEDLINE
DCOM- 20161111
LR  - 20220330
IS  - 1095-9939 (Electronic)
IS  - 0048-3575 (Linking)
VI  - 128
DP  - 2016 Mar
TI  - Reduction of chlorpyrifos-induced toxicity in human lymphocytes by selected 
      phosphodiesterase inhibitors.
PG  - 57-62
LID - S0048-3575(15)30043-2 [pii]
LID - 10.1016/j.pestbp.2015.10.005 [doi]
AB  - One of the most famous and commonly used compounds from organophosphate (OP) 
      family is chlorpyrifos (CP) which is widespreadly used as a powerful insecticide. 
      Previous studies have shown that OPs induce oxidative stress, inflammation and 
      apoptosis by generating the free radicals. The protective effects of three 
      members of phosphodiesterase inhibitor (PDEI) family, including rolipram (RLP), 
      milrinon (MLR) and pentoxifylline (PTX) were evaluated in the human lymphocytes 
      against CP's toxicity. In this case, the level of oxidative stress biomarkers, 
      the viability of the cells and the rate of apoptosis by flow cytometry were 
      investigated. The results of this study revealed that CP makes a significant 
      increase in the level of inflammatory and oxidative stress markers such as 
      meyloperoxidase (MPO), lipid peroxidation (LPO), total thiol molecules (TTM) and 
      total antioxidant potential (TAP), and also makes an enhancement in the rate of 
      apoptosis process. On the other hand, PDEIs and specifically the combination of 
      them restored the negative effects of CP and significantly prevented the 
      apoptosis and oxidative stress imbalance. It is concluded that these PDEIs have 
      positive effects in attenuation, recovery, and protection of CP-induced toxicity 
      in the human lymphocytes.
CI  - Copyright (c) 2015 Elsevier Inc. All rights reserved.
FAU - Jowzi, Narges
AU  - Jowzi N
AD  - Faculty of Pharmacy, and Pharmaceutical Sciences Research Center, Tehran 
      University of Medical Sciences, Tehran 1417614411, Iran.
FAU - Rahimifard, Mahban
AU  - Rahimifard M
AD  - Faculty of Pharmacy, and Pharmaceutical Sciences Research Center, Tehran 
      University of Medical Sciences, Tehran 1417614411, Iran.
FAU - Navaei-Nigjeh, Mona
AU  - Navaei-Nigjeh M
AD  - Faculty of Pharmacy, and Pharmaceutical Sciences Research Center, Tehran 
      University of Medical Sciences, Tehran 1417614411, Iran; Department of Tissue 
      Engineering, School of Advanced Technologies in Medicine, Tehran University of 
      Medical Sciences, Tehran, Iran.
FAU - Baeeri, Maryam
AU  - Baeeri M
AD  - Faculty of Pharmacy, and Pharmaceutical Sciences Research Center, Tehran 
      University of Medical Sciences, Tehran 1417614411, Iran.
FAU - Darvishi, Behrad
AU  - Darvishi B
AD  - Faculty of Pharmacy, and Pharmaceutical Sciences Research Center, Tehran 
      University of Medical Sciences, Tehran 1417614411, Iran.
FAU - Rezvanfar, Mohammad Amin
AU  - Rezvanfar MA
AD  - Faculty of Pharmacy, and Pharmaceutical Sciences Research Center, Tehran 
      University of Medical Sciences, Tehran 1417614411, Iran.
FAU - Abdollahi, Mohammad
AU  - Abdollahi M
AD  - Faculty of Pharmacy, and Pharmaceutical Sciences Research Center, Tehran 
      University of Medical Sciences, Tehran 1417614411, Iran; Endocrinology & 
      Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences 
      Institute, Tehran University of Medical Sciences, Tehran, Iran; Toxicology and 
      Poisoning Research Center, Tehran University of Medical Sciences, Tehran, Iran.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20151009
PL  - United States
TA  - Pestic Biochem Physiol
JT  - Pesticide biochemistry and physiology
JID - 1301573
RN  - 0 (Organophosphorus Compounds)
RN  - 0 (Phosphodiesterase Inhibitors)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - EC 1.11.1.7 (Peroxidase)
RN  - EC 3.1.1.7 (Acetylcholinesterase)
RN  - JCS58I644W (Chlorpyrifos)
SB  - IM
MH  - Acetylcholinesterase/metabolism
MH  - Chlorpyrifos/*toxicity
MH  - Flow Cytometry
MH  - Humans
MH  - Lipid Peroxidation
MH  - Lymphocytes/*drug effects
MH  - Organophosphorus Compounds/*toxicity
MH  - Peroxidase/metabolism
MH  - Phosphodiesterase Inhibitors/*pharmacology
MH  - Tumor Necrosis Factor-alpha/metabolism
OTO - NOTNLM
OT  - Apoptosis
OT  - Chlorpyrifos
OT  - Human lymphocytes
OT  - Oxidative stress
OT  - Phosphodiesterase inhibitors
EDAT- 2016/03/13 06:00
MHDA- 2016/11/12 06:00
CRDT- 2016/03/13 06:00
PHST- 2015/04/04 00:00 [received]
PHST- 2015/08/25 00:00 [revised]
PHST- 2015/10/07 00:00 [accepted]
PHST- 2016/03/13 06:00 [entrez]
PHST- 2016/03/13 06:00 [pubmed]
PHST- 2016/11/12 06:00 [medline]
AID - S0048-3575(15)30043-2 [pii]
AID - 10.1016/j.pestbp.2015.10.005 [doi]
PST - ppublish
SO  - Pestic Biochem Physiol. 2016 Mar;128:57-62. doi: 10.1016/j.pestbp.2015.10.005. 
      Epub 2015 Oct 9.