PMID- 26969607
OWN - NLM
STAT- MEDLINE
DCOM- 20170330
LR  - 20170330
IS  - 1442-200X (Electronic)
IS  - 1328-8067 (Linking)
VI  - 58
IP  - 11
DP  - 2016 Nov
TI  - Increased oxidative stress in patients with severe disability: Association with 
      nutrition.
PG  - 1183-1187
LID - 10.1111/ped.12977 [doi]
AB  - BACKGROUND: Previous studies have described a role of oxidative stress in the 
      pathogenesis of various pediatric disorders, but investigation into oxidative 
      stress status in patients with severe disability remains limited. The aim of the 
      present study was therefore to clarify the oxidative stress status in patients 
      with severe disability, focusing specifically on intake of three major nutrients 
      and micronutrients with antioxidant activities. METHODS: Thirty-one patients with 
      severe disability (mean age, 14.1 +/- 7.8 years) were enrolled. Three in vivo 
      biomarkers, plasma biological antioxidant potential (BAP), plasma reactive oxygen 
      metabolite-derived compounds (d-ROM), and urinary 8-hydroxydeoxyguanosine 
      (8-OHdG), were determined for evaluating oxidative status. The dietary intake of 
      three major nutrients and various micronutrients was estimated from dietary 
      records over a 3 day period. RESULTS: In patients with severe disability, BAP was 
      significantly lower and d-ROM and 8-OHdG significantly higher than in historical 
      controls. Among these markers, a significant positive correlation was found in 
      BAP versus d-ROM and d-ROM versus 8-OHdG. On multiple regression analysis, a 
      significant inverse association between 8-OHdG and carotenoid intake was seen. 
      CONCLUSION: The oxidative/antioxidative balance shifts towards oxidative status 
      dominance in patients with severe disability. More research is needed on 
      nutritional intake of antioxidative nutrients to determine whether they can be 
      used to reduce oxidative stress.
CI  - (c) 2016 Japan Pediatric Society.
FAU - Kawaguchi, Chiharu
AU  - Kawaguchi C
AD  - Department of Pediatrics, Todaiji Medical and Education Center, Nara, Japan.
FAU - Morinaga, Marie
AU  - Morinaga M
AD  - Faculty of Human Life and Environment, Nara Women's University, Nara, Japan.
FAU - Kubota, Masaru
AU  - Kubota M
AD  - Faculty of Human Life and Environment, Nara Women's University, Nara, Japan.
AD  - Faculty of Agriculture, Ryukoku University, Kyoto, Japan.
FAU - Saito, Hiromi
AU  - Saito H
AD  - Faculty of Human Life and Environment, Nara Women's University, Nara, Japan.
FAU - Tomiwa, Kiyotaka
AU  - Tomiwa K
AD  - Department of Pediatrics, Todaiji Medical and Education Center, Nara, Japan.
FAU - Uchiike, Nobuo
AU  - Uchiike N
AD  - Health Management Center, Nara Medical University, Nara, Japan.
LA  - eng
PT  - Journal Article
DEP - 20160710
PL  - Australia
TA  - Pediatr Int
JT  - Pediatrics international : official journal of the Japan Pediatric Society
JID - 100886002
RN  - 0 (Antioxidants)
RN  - 0 (Biomarkers)
RN  - 0 (Reactive Oxygen Species)
SB  - IM
MH  - Adolescent
MH  - Antioxidants
MH  - Biomarkers/*blood
MH  - Child
MH  - Child, Preschool
MH  - *Disabled Persons
MH  - Female
MH  - Humans
MH  - Infant
MH  - Male
MH  - *Nutritional Status
MH  - *Oxidative Stress
MH  - Reactive Oxygen Species/blood
OTO - NOTNLM
OT  - 8-hydroxydeoxyguanosine
OT  - biological antioxidant potential
OT  - disabled patient
OT  - micronutrient
OT  - oxidative stress
EDAT- 2016/03/13 06:00
MHDA- 2017/03/31 06:00
CRDT- 2016/03/13 06:00
PHST- 2015/12/21 00:00 [received]
PHST- 2016/02/25 00:00 [revised]
PHST- 2016/03/04 00:00 [accepted]
PHST- 2016/03/13 06:00 [pubmed]
PHST- 2017/03/31 06:00 [medline]
PHST- 2016/03/13 06:00 [entrez]
AID - 10.1111/ped.12977 [doi]
PST - ppublish
SO  - Pediatr Int. 2016 Nov;58(11):1183-1187. doi: 10.1111/ped.12977. Epub 2016 Jul 10.