PMID- 26970335
OWN - NLM
STAT- MEDLINE
DCOM- 20170317
LR  - 20170817
IS  - 1651-2227 (Electronic)
IS  - 0803-5253 (Linking)
VI  - 105
IP  - 11
DP  - 2016 Nov
TI  - High levels of omega-3 fatty acids in milk from omega-3 fatty acid-supplemented 
      mothers are related to less immunoglobulin E-associated disease in infancy.
PG  - 1337-1347
LID - 10.1111/apa.13395 [doi]
AB  - AIM: We previously reported a protective effect of maternal omega-3 fatty acid 
      supplements on the development of immunoglobulin E (IgE)-associated disease in 
      infancy. This study assessed omega-3 long-chain polyunsaturated fatty acids 
      (LCPUFA) in maternal milk in relation to omega-3 LCPUFA supplementation and the 
      development of allergic disease in their infants. METHODS: This study randomised 
      95 pregnant women at risk of having an allergic infant, to daily supplements of 
      2.6 g omega-3 LCPUFA or a placebo of 2.7 g soya bean oil from gestational week 25 
      until 3 months of lactation. Breast milk samples were collected as colostrum, at 
      one and 3 months. Milk fatty acids were related to allergic outcome in the 
      infants at 24 months. RESULTS: Omega-3 milk fatty acids were higher in women who 
      received omega-3 supplements than the placebo group (p < 0.01). Higher 
      proportions of milk eicosapentaenoic acid and docosahexaenoic acid and a lower 
      arachidonic/eicosapentaenoic acid ratio were associated with an absence of 
      IgE-associated disease in the infants. None of the children developed 
      IgE-associated atopic eczema above a level of 0.83 mol% eicosapentaenoic acid in 
      colostrum. [Correction added on 7 July 2016, after online publication: In the 
      preceding sentence, the correct word should be "above" instead of "below" and 
      this has been amended in this current version.] CONCLUSION: High omega-3 LCPUFA 
      milk levels in mothers who received omega-3 LCPUFA supplements were related to 
      fewer allergies in their children.
CI  - (c)2016 Foundation Acta Paediatrica. Published by John Wiley & Sons Ltd.
FAU - Warstedt, Kristina
AU  - Warstedt K
AD  - Division of Pediatrics, Department of Clinical and Experimental Medicine, Faculty 
      of Medicine, Linkoping University, Linkoping, Sweden.
AD  - Clinical and Experimental Research, Faculty of Medicine, Linkoping University, 
      Linkoping, Sweden.
FAU - Furuhjelm, Catrin
AU  - Furuhjelm C
AD  - Division of Pediatrics, Department of Clinical and Experimental Medicine, Faculty 
      of Medicine, Linkoping University, Linkoping, Sweden.
AD  - Childrens Hospital, Linkoping University Hospital, The County Council in 
      Ostergotland, Linkoping, Sweden.
FAU - Falth-Magnusson, Karin
AU  - Falth-Magnusson K
AD  - Division of Pediatrics, Department of Clinical and Experimental Medicine, Faculty 
      of Medicine, Linkoping University, Linkoping, Sweden.
AD  - Childrens Hospital, Linkoping University Hospital, The County Council in 
      Ostergotland, Linkoping, Sweden.
FAU - Fageras, Malin
AU  - Fageras M
AD  - Division of Pediatrics, Department of Clinical and Experimental Medicine, Faculty 
      of Medicine, Linkoping University, Linkoping, Sweden.
AD  - AstraZeneca, Molndal, Sweden.
FAU - Duchen, Karel
AU  - Duchen K
AD  - Division of Pediatrics, Department of Clinical and Experimental Medicine, Faculty 
      of Medicine, Linkoping University, Linkoping, Sweden. 
      Karel.Duchen.Munoz@regionostergotland.se.
AD  - Childrens Hospital, Linkoping University Hospital, The County Council in 
      Ostergotland, Linkoping, Sweden. Karel.Duchen.Munoz@regionostergotland.se.
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20160408
PL  - Norway
TA  - Acta Paediatr
JT  - Acta paediatrica (Oslo, Norway : 1992)
JID - 9205968
RN  - 0 (Fatty Acids, Omega-3)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
CIN - Acta Paediatr. 2016 Nov;105(11):1348. PMID: 27381168
MH  - Adult
MH  - *Breast Feeding
MH  - *Dietary Supplements
MH  - Fatty Acids, Omega-3/administration & dosage/*immunology
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Hypersensitivity/*prevention & control
MH  - *Immunity, Maternally-Acquired
MH  - Immunoglobulin E/immunology
MH  - Infant
MH  - Infant, Newborn
MH  - Maternal Nutritional Physiological Phenomena/drug effects/*immunology
MH  - Milk, Human/chemistry/*immunology
MH  - Pregnancy
MH  - Skin Tests
MH  - Sweden
OTO - NOTNLM
OT  - Allergic disease
OT  - Breastfeeding
OT  - Immunoglobulin E
OT  - Omega-3
OT  - Pregnancy
EDAT- 2016/03/13 06:00
MHDA- 2017/03/18 06:00
CRDT- 2016/03/13 06:00
PHST- 2015/09/18 00:00 [received]
PHST- 2015/12/30 00:00 [revised]
PHST- 2016/03/07 00:00 [accepted]
PHST- 2016/03/13 06:00 [pubmed]
PHST- 2017/03/18 06:00 [medline]
PHST- 2016/03/13 06:00 [entrez]
AID - 10.1111/apa.13395 [doi]
PST - ppublish
SO  - Acta Paediatr. 2016 Nov;105(11):1337-1347. doi: 10.1111/apa.13395. Epub 2016 Apr 
      8.