PMID- 26970388
OWN - NLM
STAT- MEDLINE
DCOM- 20170531
LR  - 20181202
IS  - 1879-0410 (Electronic)
IS  - 0955-0674 (Linking)
VI  - 40
DP  - 2016 Jun
TI  - Cell cycle control of DNA joint molecule resolution.
PG  - 74-80
LID - S0955-0674(16)30025-4 [pii]
LID - 10.1016/j.ceb.2016.02.018 [doi]
AB  - The establishment of stable interactions between chromosomes underpins vital 
      cellular processes such as recombinational DNA repair and bipolar chromosome 
      segregation. On the other hand, timely disengagement of persistent connections is 
      necessary to assure efficient partitioning of the replicated genome prior to cell 
      division. Whereas great progress has been made in defining how cohesin-mediated 
      chromosomal interactions are disengaged as cells prepare to undergo chromosome 
      segregation, little is known about the metabolism of DNA joint molecules (JMs), 
      generated during the repair of chromosomal lesions. Recent work on Mus81 and 
      Yen1/GEN1, two conserved structure-selective endonucleases, revealed unforeseen 
      links between JM-processing and cell cycle progression. Cell cycle kinases and 
      phosphatases control Mus81 and Yen1/GEN1 to restrain deleterious JM-processing 
      during S-phase, while safeguarding chromosome segregation during mitosis.
CI  - Copyright (c) 2016 Elsevier Ltd. All rights reserved.
FAU - Wild, Philipp
AU  - Wild P
AD  - Institute of Biochemistry, HPM D6.5 - ETH Zurich, Otto-Stern-Weg 3, 8093 Zurich, 
      Switzerland.
FAU - Matos, Joao
AU  - Matos J
AD  - Institute of Biochemistry, HPM D6.5 - ETH Zurich, Otto-Stern-Weg 3, 8093 Zurich, 
      Switzerland. Electronic address: joao.matos@bc.biol.ethz.ch.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20160309
PL  - England
TA  - Curr Opin Cell Biol
JT  - Current opinion in cell biology
JID - 8913428
RN  - 0 (DNA, Cruciform)
RN  - 9007-49-2 (DNA)
SB  - IM
MH  - Animals
MH  - *Cell Cycle
MH  - Chromosome Segregation
MH  - Chromosomes/metabolism
MH  - DNA/*metabolism
MH  - *DNA Repair
MH  - DNA, Cruciform
MH  - Humans
MH  - Saccharomycetales/classification/*cytology/*metabolism
EDAT- 2016/03/13 06:00
MHDA- 2017/06/01 06:00
CRDT- 2016/03/13 06:00
PHST- 2015/11/24 00:00 [received]
PHST- 2016/02/02 00:00 [revised]
PHST- 2016/02/19 00:00 [accepted]
PHST- 2016/03/13 06:00 [entrez]
PHST- 2016/03/13 06:00 [pubmed]
PHST- 2017/06/01 06:00 [medline]
AID - S0955-0674(16)30025-4 [pii]
AID - 10.1016/j.ceb.2016.02.018 [doi]
PST - ppublish
SO  - Curr Opin Cell Biol. 2016 Jun;40:74-80. doi: 10.1016/j.ceb.2016.02.018. Epub 2016 
      Mar 9.