PMID- 26971581
OWN - NLM
STAT- MEDLINE
DCOM- 20170623
LR  - 20180618
IS  - 1096-8652 (Electronic)
IS  - 0361-8609 (Linking)
VI  - 91
IP  - 6
DP  - 2016 Jun
TI  - Safety and efficacy of rapid (1,000 mg in 1 hr) intravenous iron dextran for 
      treatment of maternal iron deficient anemia of pregnancy.
PG  - 590-3
LID - 10.1002/ajh.24361 [doi]
AB  - Maternal iron deficiency anemia (IDA) is associated with risk of adverse 
      perinatal outcomes. Oral iron is recommended to reverse anemia, but has 
      gastrointestinal toxicity and frequent non-adherence. Intravenous (IV) iron is 
      reserved for intolerance of, or unresponsiveness to, oral therapy, malabsorption, 
      and severe anemia (1% with hemoglobin [Hgb] levels <7 g/dL). With rare (<100 per 
      one million) adverse events (AEs) ability to infuse a sufficient dose of low 
      molecular weight iron dextran (LMWID) over 60 min, LMWID is an attractive option. 
      This study demonstrated safety and efficacy of rapid IV infusion of 1,000 mg 
      LMWID to gravidas with moderate to severe IDA. An observational treatment study 
      of 1,000 mg LMWID administered over 1 hr for IDA in 189 consecutive, unselected 
      second and third trimester gravidas after oral iron failure was conducted. All 
      received a test dose of 25 mg LMWID and were monitored for AEs during the 60-min 
      infusion. No premedication was administered unless more than one drug allergy or 
      asthma was present in which case IV methylprednisolone was administered. All were 
      followed through pregnancy and delivery. Monitored parameters included Hgb, mean 
      corpuscular volume, serum ferritin, and percent transferrin saturation. About 189 
      subjects received 1,000 mg LMWID. No serious AEs occurred. About 2% experienced 
      transient infusion reactions. Hgb improved by 1-1.9 g/dL in 82% and >/=2 g/dL in 
      24%. Second trimester treatment was not associated with greater Hgb improvement 
      than third trimester treatment. Anemia resolved in 95%. Administration of a 
      single large dose of IV LMWID was effective, safe, and convenient. Am. J. 
      Hematol. 91:590-593, 2016. (c) 2016 Wiley Periodicals, Inc.
CI  - (c) 2016 Wiley Periodicals, Inc.
FAU - Wong, Lee
AU  - Wong L
AD  - Department of Obstetrics and Gynecology, MedStar Franklin Square Medical Center, 
      Baltimore, Maryland.
FAU - Smith, Samuel
AU  - Smith S
AD  - Department of Obstetrics and Gynecology, MedStar Franklin Square Medical Center, 
      Baltimore, Maryland.
FAU - Gilstrop, Marisa
AU  - Gilstrop M
AD  - Department of Obstetrics and Gynecology, Christiana Care Health System, Newark, 
      Delaware.
FAU - Derman, Richard
AU  - Derman R
AD  - Department of Obstetrics and Gynecology, Christiana Care Health System, Newark, 
      Delaware.
FAU - Auerbach, Sarah
AU  - Auerbach S
AD  - West Virginia School of Osteopathic Medicine, Lewisburg, West Virginia.
FAU - London, Nicola
AU  - London N
AD  - Department of Obstetrics and Gynecology, MedStar Franklin Square Medical Center, 
      Baltimore, Maryland.
FAU - Lenowitz, Steven
AU  - Lenowitz S
AD  - Department of Obstetrics and Gynecology, MedStar Franklin Square Medical Center, 
      Baltimore, Maryland.
FAU - Bahrain, Huzefa
AU  - Bahrain H
AD  - Auerbach Hematology and Oncology, Baltimore, Maryland.
FAU - McClintock, Jessica
AU  - McClintock J
AD  - Department of Obstetrics and Gynecology, MedStar Franklin Square Medical Center, 
      Baltimore, Maryland.
FAU - Auerbach, Michael
AU  - Auerbach M
AD  - Department of Medicine, Georgetown University School of Medicine, Washington, DC.
LA  - eng
PT  - Journal Article
DEP - 20160413
PL  - United States
TA  - Am J Hematol
JT  - American journal of hematology
JID - 7610369
RN  - 0 (Hemoglobins)
RN  - 0 (Transferrin)
RN  - 9004-66-4 (Iron-Dextran Complex)
RN  - 9007-73-2 (Ferritins)
SB  - IM
MH  - Administration, Intravenous
MH  - Adult
MH  - Anemia, Iron-Deficiency/complications/*drug therapy
MH  - Erythrocyte Indices
MH  - Female
MH  - Ferritins/blood
MH  - Gravidity
MH  - Hemoglobins/analysis
MH  - Humans
MH  - Iron-Dextran Complex/*administration & dosage/adverse effects
MH  - Pregnancy
MH  - Retrospective Studies
MH  - Transferrin/analysis
MH  - Treatment Outcome
EDAT- 2016/03/15 06:00
MHDA- 2017/06/24 06:00
CRDT- 2016/03/15 06:00
PHST- 2016/02/22 00:00 [received]
PHST- 2016/03/05 00:00 [revised]
PHST- 2016/03/07 00:00 [accepted]
PHST- 2016/03/15 06:00 [entrez]
PHST- 2016/03/15 06:00 [pubmed]
PHST- 2017/06/24 06:00 [medline]
AID - 10.1002/ajh.24361 [doi]
PST - ppublish
SO  - Am J Hematol. 2016 Jun;91(6):590-3. doi: 10.1002/ajh.24361. Epub 2016 Apr 13.