PMID- 2697183
OWN - NLM
STAT- MEDLINE
DCOM- 19900412
LR  - 20151119
IS  - 0250-7005 (Print)
IS  - 0250-7005 (Linking)
VI  - 9
IP  - 6
DP  - 1989 Nov-Dec
TI  - Human leukocyte antigen (HLA) frequency among patients with nasopharyngeal 
      carcinoma in Taiwan.
PG  - 1649-53
AB  - In order to assess the association between human leukocyte antigens (HLA) and 
      nasopharyngeal carcinoma (NPC), a total of 10 familial and 10 sporadic NPC 
      patients and 171 unrelated healthy controls were studied. HLA typing was 
      performed using commercial trays which defined 30 specificities of HLA-A, B and C 
      loci and 10 specificities of HLA-D locus according to the method of Tiwari and 
      Terasaki. HLA-A2, B16 and DR1 were found to be higher among patients with NPC 
      than unrelated healthy controls with an odds ratio (OR) and a 95% confidence 
      interval of 5.91 (2.1-16.6), 6.00 (2.0-18.0) and 6.89 (1.3-37.5), respectively. 
      Further analysis showed that A2(+) B16(+) haplotype was significantly associated 
      with a much higher risk of NPC (OR = 15.5) as compared with A2(-) B16(-) 
      haplotype. No difference in frequency distributions of HLA-A, B, C and D antigens 
      was observed between familial and sporadic NPC patients.
FAU - Wu, S B
AU  - Wu SB
AD  - Institute of Public Health, National Taiwan University College of Medicine, 
      Taipei.
FAU - Hwang, S J
AU  - Hwang SJ
FAU - Chang, A S
AU  - Chang AS
FAU - Hsieh, T
AU  - Hsieh T
FAU - Hsu, M M
AU  - Hsu MM
FAU - Hsieh, R P
AU  - Hsieh RP
FAU - Chen, C J
AU  - Chen CJ
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Greece
TA  - Anticancer Res
JT  - Anticancer research
JID - 8102988
RN  - 0 (Antigens, CD)
RN  - 0 (Antigens, Differentiation)
RN  - 0 (Biomarkers, Tumor)
RN  - 0 (HLA Antigens)
RN  - 0 (Lymphocyte Function-Associated Antigen-1)
RN  - 0 (Receptors, Leukocyte-Adhesion)
SB  - IM
MH  - Adult
MH  - Antigens, CD/*analysis
MH  - Antigens, Differentiation/*analysis
MH  - Biomarkers, Tumor/*analysis
MH  - Female
MH  - HLA Antigens/analysis
MH  - Haplotypes
MH  - Humans
MH  - Lymphocyte Function-Associated Antigen-1
MH  - Male
MH  - Nasopharyngeal Neoplasms/diagnosis/genetics/*immunology
MH  - Receptors, Leukocyte-Adhesion/*analysis
MH  - Reference Values
MH  - Taiwan
EDAT- 1989/11/01 00:00
MHDA- 1989/11/01 00:01
CRDT- 1989/11/01 00:00
PHST- 1989/11/01 00:00 [pubmed]
PHST- 1989/11/01 00:01 [medline]
PHST- 1989/11/01 00:00 [entrez]
PST - ppublish
SO  - Anticancer Res. 1989 Nov-Dec;9(6):1649-53.