PMID- 26971848
OWN - NLM
STAT- MEDLINE
DCOM- 20161213
LR  - 20181202
IS  - 1878-1594 (Electronic)
IS  - 1521-690X (Linking)
VI  - 30
IP  - 1
DP  - 2016 Jan
TI  - Somatic and germline mutations in NETs: Implications for their diagnosis and 
      management.
PG  - 115-27
LID - S1521-690X(15)00096-2 [pii]
LID - 10.1016/j.beem.2015.09.007 [doi]
AB  - It is now understood that specific somatic and germline mutations may lead to the 
      development of the neuroendocrine tumours (NETs). NETs usually occur as sporadic 
      isolated tumours, although they also may present as part of complex familial 
      endocrine cancer syndromes, such as multiple endocrine neoplasia type 1 (MEN1) 
      and type 2 (MEN2), Von Hippel-Lindau (VHL) and neurofibromatosis syndromes, 
      tuberous sclerosis, Carney triad and dyad, Reed syndrome and 
      polycythaemia-paraganglioma syndromes. Only in MEN2 syndrome is there a specific 
      genotype-phenotype correlation, although in both sporadic and syndromic NETs some 
      gene mutations are associated with specific clinico-pathological features and 
      prognosis. There have been several advances in our understanding of the NETs 
      leading to earlier detection and targeted therapeutic treatment, but given the 
      poor prognosis associated with metastatic NETs, it will be necessary to find new 
      biomarkers for the prediction of malignant potential and to find novel 
      therapeutic targets for NETs.
CI  - Copyright (c) 2015 Elsevier Ltd. All rights reserved.
FAU - Minnetti, Marianna
AU  - Minnetti M
AD  - Dept. of Endocrinology, Oxford Centre for Diabetes, Endocrinology and Metabolism, 
      Radcliffe Dept. of Medicine, University of Oxford, UK.
FAU - Grossman, Ashley
AU  - Grossman A
AD  - Dept. of Endocrinology, Oxford Centre for Diabetes, Endocrinology and Metabolism, 
      Radcliffe Dept. of Medicine, University of Oxford, UK. Electronic address: 
      Ashley.grossman@ocdem.ox.ac.uk.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20151009
PL  - Netherlands
TA  - Best Pract Res Clin Endocrinol Metab
JT  - Best practice & research. Clinical endocrinology & metabolism
JID - 101120682
SB  - IM
MH  - Genes, Neoplasm
MH  - Genetic Testing/methods
MH  - *Germ-Line Mutation
MH  - Humans
MH  - Neuroendocrine Tumors/diagnosis/*genetics/therapy
OTO - NOTNLM
OT  - genetic
OT  - lung NETs
OT  - multiple endocrine neoplasia
OT  - mutation
OT  - neuroendocrine tumour
OT  - pancreatic NETs
OT  - paraganglioma/phaeocromocytoma
OT  - sporadic NETs
OT  - syndromic NETs
EDAT- 2016/03/15 06:00
MHDA- 2016/12/15 06:00
CRDT- 2016/03/15 06:00
PHST- 2016/03/15 06:00 [entrez]
PHST- 2016/03/15 06:00 [pubmed]
PHST- 2016/12/15 06:00 [medline]
AID - S1521-690X(15)00096-2 [pii]
AID - 10.1016/j.beem.2015.09.007 [doi]
PST - ppublish
SO  - Best Pract Res Clin Endocrinol Metab. 2016 Jan;30(1):115-27. doi: 
      10.1016/j.beem.2015.09.007. Epub 2015 Oct 9.