PMID- 26971884
OWN - NLM
STAT- MEDLINE
DCOM- 20170117
LR  - 20170117
IS  - 1097-0029 (Electronic)
IS  - 1059-910X (Linking)
VI  - 79
IP  - 5
DP  - 2016 May
TI  - Postnatal development of Mongolian gerbil female prostate: An immunohistochemical 
      and 3D modeling study.
PG  - 438-46
LID - 10.1002/jemt.22649 [doi]
AB  - The development of the prostate in male rodents, which involves complex 
      epithelial-mesenchymal interactions between the urogenital sinus epithelium (UGE) 
      and the urogenital sinus mesenchyme (UGM), has been deeply studied. In females, 
      however, this process is not very clear. In this study, the postnatal development 
      of the prostate in female Mongolian gerbils employing three-dimensional (3D) 
      reconstructions, histochemical, and immunohistochemical techniques was 
      characterized. It was observed that prostatic branching and differentiation in 
      females was induced by a single mesenchyme localized at a ventrolateral position, 
      which was named as ventrolateral mesenchyme (VLM); furthermore, the canalization 
      of solid buds began on the third postnatal day (P3) and the branching 
      morphogenesis on P5. We observed secretions in the acini at the end of the first 
      month, and, on P45, the acini were completely differentiated. The strong cell 
      proliferation phase in the first week coincided with the mesenchymal expression 
      of estrogen receptor 1 (ESR1). The expression of androgen receptor (AR) 
      paralleled cell differentiation, and, on P30, immunolabelling with p63 was 
      restricted to basal cells. This study serves as a baseline parameter for future 
      research on disruptions that could affect the development of the female prostate.
CI  - (c) 2016 Wiley Periodicals, Inc.
FAU - Sanches, Bruno D A
AU  - Sanches BD
AD  - Department of Structural and Functional Biology, State University of Campinas, 
      Av. Bertrand Russel s/n, Campinas, Sao Paulo, Brazil.
FAU - Zani, Bruno C
AU  - Zani BC
AD  - Department of Biology, Laboratory of Microscopy and Microanalysis, University of 
      Estadual Paulista - UNESP, Rua Cristovao Colombo, Sao Jose do Rio Preto, Sao 
      Paulo, Brazil.
FAU - Maldarine, Juliana S
AU  - Maldarine JS
AD  - Department of Biology, Laboratory of Microscopy and Microanalysis, University of 
      Estadual Paulista - UNESP, Rua Cristovao Colombo, Sao Jose do Rio Preto, Sao 
      Paulo, Brazil.
FAU - Biancardi, Manoel F
AU  - Biancardi MF
AD  - Department of Morphology, Federal University of Goias, Samambaia II, Goiania, 
      Goias, Brazil.
FAU - Santos, Fernanda C A
AU  - Santos FC
AD  - Department of Morphology, Federal University of Goias, Samambaia II, Goiania, 
      Goias, Brazil.
FAU - Goes, Rejane M
AU  - Goes RM
AD  - Department of Biology, Laboratory of Microscopy and Microanalysis, University of 
      Estadual Paulista - UNESP, Rua Cristovao Colombo, Sao Jose do Rio Preto, Sao 
      Paulo, Brazil.
FAU - Vilamaior, Patricia S L
AU  - Vilamaior PS
AD  - Department of Biology, Laboratory of Microscopy and Microanalysis, University of 
      Estadual Paulista - UNESP, Rua Cristovao Colombo, Sao Jose do Rio Preto, Sao 
      Paulo, Brazil.
FAU - Taboga, Sebastiao R
AU  - Taboga SR
AD  - Department of Biology, Laboratory of Microscopy and Microanalysis, University of 
      Estadual Paulista - UNESP, Rua Cristovao Colombo, Sao Jose do Rio Preto, Sao 
      Paulo, Brazil.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20160312
PL  - United States
TA  - Microsc Res Tech
JT  - Microscopy research and technique
JID - 9203012
RN  - 0 (Estrogen Receptor alpha)
RN  - 0 (Receptors, Androgen)
SB  - IM
MH  - Animals
MH  - Cell Differentiation
MH  - Estrogen Receptor alpha/metabolism
MH  - Female
MH  - Gerbillinae/*embryology/metabolism
MH  - Male
MH  - Prostate/cytology/*embryology/metabolism
MH  - Receptors, Androgen/metabolism
OTO - NOTNLM
OT  - branching morphogenesis
OT  - female prostate
OT  - prostate development
OT  - ventrolateral mesenchyme
EDAT- 2016/03/15 06:00
MHDA- 2017/01/18 06:00
CRDT- 2016/03/15 06:00
PHST- 2015/11/25 00:00 [received]
PHST- 2016/02/20 00:00 [accepted]
PHST- 2016/03/15 06:00 [entrez]
PHST- 2016/03/15 06:00 [pubmed]
PHST- 2017/01/18 06:00 [medline]
AID - 10.1002/jemt.22649 [doi]
PST - ppublish
SO  - Microsc Res Tech. 2016 May;79(5):438-46. doi: 10.1002/jemt.22649. Epub 2016 Mar 
      12.