PMID- 26972401
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20160314
LR  - 20180219
IS  - 2352-4146 (Electronic)
IS  - 1995-7645 (Linking)
VI  - 9
IP  - 3
DP  - 2016 Mar
TI  - Regulating effect of activated NF-kappaB on edema induced by traumatic brain injury 
      of rats.
PG  - 274-7
LID - S1995-7645(16)00028-6 [pii]
LID - 10.1016/j.apjtm.2016.01.027 [doi]
AB  - OBJECTIVE: To observe the effect of nuclear transcription factor-kappaB (NF-kappaB) on 
      cerebral edema in rats with traumatic brain injury (TBI). METHODS: Male SD rats 
      with fluid percussion injury (FPI) were selected. After separation and culture, 
      rats' astrocytes all suffered FPI. The expression of NF-kappaB and the water content 
      were detected at the animal and cellular levels, while the activity of NOX was 
      evaluated at the cellular level. RESULTS: According to the results, the positive 
      expression of NF-kappaB and expression of mRNA were significantly increased and the 
      water content was increased for rats after TBI, while NF-kappaB inhibitor BAY11-7082 
      could significantly reduce the effect of TBI. 1 and 3 h after FPI of astrocytes, 
      the activation of NF-kappaB was increased and BAY 11-7082 could significantly improve 
      the injury-induced swelling of astrocytes. After the injury of astrocytes, the 
      activity of NOX was also increased, while BAY 11-7082 could reduce the activity 
      of NOX. CONCLUSIONS: The results show that the activation of NF-kappaB in astrocytes 
      is a key factor in the process of cerebral edema after TBI of rats.
CI  - Copyright (c) 2016 Hainan Medical College. Production and hosting by Elsevier B.V. 
      All rights reserved.
FAU - Wang, Zi-Ran
AU  - Wang ZR
AD  - Department of Cerebral Surgery, Linyi People's Hospital, Shandong 276000, China.
FAU - Li, Yu-Xin
AU  - Li YX
AD  - Department of Cerebral Surgery, Linyi People's Hospital, Shandong 276000, China.
FAU - Lei, Hong-Yan
AU  - Lei HY
AD  - Department of Cerebral Surgery, Linyi People's Hospital, Shandong 276000, China.
FAU - Yang, Dai-Qun
AU  - Yang DQ
AD  - Department of Cerebral Surgery, Linyi People's Hospital, Shandong 276000, China.
FAU - Wang, Li-Quan
AU  - Wang LQ
AD  - Department of Cerebral Surgery, Linyi People's Hospital, Shandong 276000, China.
FAU - Luo, Ming-Yu
AU  - Luo MY
AD  - Department of Cerebral Surgery, Linyi People's Hospital, Shandong 276000, China. 
      Electronic address: nyjzlhy@163.com.
LA  - eng
PT  - Journal Article
DEP - 20160115
PL  - India
TA  - Asian Pac J Trop Med
JT  - Asian Pacific journal of tropical medicine
JID - 101533720
OTO - NOTNLM
OT  - Astrocytes
OT  - Nuclear transcription factor-kappaB
OT  - Rat
OT  - Traumatic brain injury
EDAT- 2016/03/15 06:00
MHDA- 2016/03/15 06:01
CRDT- 2016/03/15 06:00
PHST- 2015/12/15 00:00 [received]
PHST- 2015/12/20 00:00 [revised]
PHST- 2015/12/30 00:00 [accepted]
PHST- 2016/03/15 06:00 [entrez]
PHST- 2016/03/15 06:00 [pubmed]
PHST- 2016/03/15 06:01 [medline]
AID - S1995-7645(16)00028-6 [pii]
AID - 10.1016/j.apjtm.2016.01.027 [doi]
PST - ppublish
SO  - Asian Pac J Trop Med. 2016 Mar;9(3):274-7. doi: 10.1016/j.apjtm.2016.01.027. Epub 
      2016 Jan 15.