PMID- 26972485
OWN - NLM
STAT- MEDLINE
DCOM- 20180108
LR  - 20181113
IS  - 1098-1063 (Electronic)
IS  - 1050-9631 (Print)
IS  - 1050-9631 (Linking)
VI  - 26
IP  - 8
DP  - 2016 Aug
TI  - High-resolution investigation of memory-specific reinstatement in the hippocampus 
      and perirhinal cortex.
PG  - 995-1007
LID - 10.1002/hipo.22582 [doi]
AB  - Episodic memory involves remembering the details that characterize a prior 
      experience. Successful memory recovery has been associated with the reinstatement 
      of brain activity patterns in a number of sensory regions across the cortex. 
      However, how the hippocampus and surrounding medial temporal lobe (MTL) cortex 
      contribute to this process is less clear. Models of episodic memory posit that 
      hippocampal pattern reinstatement, also referred to as pattern completion, may 
      mediate cortical reinstatement during retrieval. Empirical evidence of this 
      process, however, remains elusive. Here, we use high-resolution fMRI and 
      encoding-retrieval multi-voxel pattern similarity analyses to demonstrate for the 
      first time that the hippocampus, particularly right hippocampal subfield CA1, 
      shows evidence of reinstating individual episodic memories. Furthermore, 
      reinstatement in perirhinal cortex (PrC) is also evident. Critically, we identify 
      distinct factors that may mediate the cortical reinstatement in PrC. First, we 
      find that encoding activation in PrC is related to later reinstatement in this 
      region, consistent with the theory that encoding strength in the regions that 
      process the memoranda is important for later reinstatement. Conversely, retrieval 
      activation in right CA1 was correlated with reinstatement in PrC, consistent with 
      models of pattern completion. This dissociation is discussed in the context of 
      the flow of information into and out of the hippocampus during encoding and 
      retrieval, respectively. (c) 2016 Wiley Periodicals, Inc.
CI  - (c) 2016 Wiley Periodicals, Inc.
FAU - Tompary, Alexa
AU  - Tompary A
AD  - Department of Psychology, New York University.
FAU - Duncan, Katherine
AU  - Duncan K
AD  - Department of Psychology, University of Toronto.
FAU - Davachi, Lila
AU  - Davachi L
AD  - Department of Psychology, New York University.
AD  - Center for Neural Science, New York University.
LA  - eng
GR  - R01 MH074692/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, U.S. Gov't, Non-P.H.S.
DEP - 20160404
PL  - United States
TA  - Hippocampus
JT  - Hippocampus
JID - 9108167
SB  - IM
MH  - Adult
MH  - Analysis of Variance
MH  - Association
MH  - Brain Mapping
MH  - CA1 Region, Hippocampal/diagnostic imaging/*physiology
MH  - Female
MH  - Functional Laterality
MH  - Humans
MH  - Logistic Models
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - *Memory, Episodic
MH  - Neuropsychological Tests
MH  - Perirhinal Cortex/diagnostic imaging/*physiology
MH  - Young Adult
PMC - PMC4949140
MID - NIHMS768851
OTO - NOTNLM
OT  - CA1
OT  - encoding-retrieval similarity
OT  - high-resolution fMRI
OT  - medial temporal lobes
EDAT- 2016/03/15 06:00
MHDA- 2018/01/09 06:00
PMCR- 2017/08/01
CRDT- 2016/03/15 06:00
PHST- 2015/09/18 00:00 [received]
PHST- 2016/02/03 00:00 [revised]
PHST- 2016/03/01 00:00 [accepted]
PHST- 2016/03/15 06:00 [entrez]
PHST- 2016/03/15 06:00 [pubmed]
PHST- 2018/01/09 06:00 [medline]
PHST- 2017/08/01 00:00 [pmc-release]
AID - 10.1002/hipo.22582 [doi]
PST - ppublish
SO  - Hippocampus. 2016 Aug;26(8):995-1007. doi: 10.1002/hipo.22582. Epub 2016 Apr 4.