PMID- 26972957
OWN - NLM
STAT- MEDLINE
DCOM- 20161213
LR  - 20181202
IS  - 1872-8227 (Electronic)
IS  - 0168-8227 (Linking)
VI  - 113
DP  - 2016 Mar
TI  - Association between vaspin level and coronary artery disease in patients with 
      type 2 diabetes.
PG  - 26-32
LID - S0168-8227(16)00002-4 [pii]
LID - 10.1016/j.diabres.2015.12.001 [doi]
AB  - AIM: Adipokines contribute to the atherosclerotic process, connecting obesity and 
      diabetes to cardiovascular disease. Vaspin is a recently discovered adipokine, so 
      data about the relationship of vaspin to coronary artery disease in type-2 
      diabetes mellitus (T2DM) is limited. The current study was designed to evaluate 
      the association of vaspin with the presence of coronary artery disease in T2DM. 
      METHODS: We enrolled 228 patients with T2DM, with or without CAD, between March 
      2010 and July 2011, and 120 healthy control participants. Serum vaspin, 
      homeostasis model assessment of insulin resistance (HOMA-IR) and other 
      cardiovascular risk factors were assayed. RESULTS: Vaspin levels were 
      significantly increased in patients with T2DM compared to healthy individuals, 
      and were further increased in patients with both T2DM and CAD compared to those 
      with T2DM but without CAD. Moreover, vaspin correlated positively with body mass 
      index, fasting plasma glucose, insulin and HOMA-IR in all patients with T2DM 
      (P<0.05). Furthermore, in multivariate logistic regression analysis, vaspin level 
      was associated with the presence of CAD in patients with T2DM. CONCLUSIONS: 
      Vaspin correlates with CAD in T2DM.
CI  - Copyright (c) 2016 Elsevier Ireland Ltd. All rights reserved.
FAU - Hao, Fei
AU  - Hao F
AD  - Department of Endocrinology, First Affiliated Hospital of Harbin Medical 
      University, 23 Youzheng Street, Nangang District, Harbin 150001, Heilongjiang, PR 
      China.
FAU - Zhang, Hiujuan
AU  - Zhang H
AD  - Department of Endocrinology, First Affiliated Hospital of Harbin Medical 
      University, 23 Youzheng Street, Nangang District, Harbin 150001, Heilongjiang, PR 
      China. Electronic address: hydzhj@126.com.
FAU - Zhu, Jinying
AU  - Zhu J
AD  - Department of Endocrinology, First Affiliated Hospital of Harbin Medical 
      University, 23 Youzheng Street, Nangang District, Harbin 150001, Heilongjiang, PR 
      China.
FAU - Kuang, Hongyu
AU  - Kuang H
AD  - Department of Endocrinology, First Affiliated Hospital of Harbin Medical 
      University, 23 Youzheng Street, Nangang District, Harbin 150001, Heilongjiang, PR 
      China.
FAU - Yu, Qiuxia
AU  - Yu Q
AD  - Department of Endocrinology, First Affiliated Hospital of Harbin Medical 
      University, 23 Youzheng Street, Nangang District, Harbin 150001, Heilongjiang, PR 
      China.
FAU - Bai, Mengmeng
AU  - Bai M
AD  - Department of Endocrinology, First Affiliated Hospital of Harbin Medical 
      University, 23 Youzheng Street, Nangang District, Harbin 150001, Heilongjiang, PR 
      China.
FAU - Mu, Jiawei
AU  - Mu J
AD  - Department of Endocrinology, First Affiliated Hospital of Harbin Medical 
      University, 23 Youzheng Street, Nangang District, Harbin 150001, Heilongjiang, PR 
      China.
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20160128
PL  - Ireland
TA  - Diabetes Res Clin Pract
JT  - Diabetes research and clinical practice
JID - 8508335
RN  - 0 (Adipokines)
RN  - 0 (Biomarkers)
RN  - 0 (Insulin)
RN  - 0 (Serpins)
SB  - IM
MH  - Adipokines/blood
MH  - Aged
MH  - Biomarkers/*blood
MH  - Case-Control Studies
MH  - Coronary Artery Disease/blood/*diagnosis/etiology
MH  - Diabetes Mellitus, Type 2/blood/*complications
MH  - Female
MH  - Humans
MH  - Insulin/blood
MH  - Insulin Resistance
MH  - Male
MH  - Middle Aged
MH  - Retrospective Studies
MH  - Risk Factors
MH  - Serpins/*blood
OTO - NOTNLM
OT  - Coronary artery disease
OT  - Diabetes mellitus
OT  - Human
OT  - Type 2
OT  - Vaspin protein
EDAT- 2016/03/15 06:00
MHDA- 2016/12/15 06:00
CRDT- 2016/03/15 06:00
PHST- 2015/07/20 00:00 [received]
PHST- 2015/12/07 00:00 [revised]
PHST- 2015/12/26 00:00 [accepted]
PHST- 2016/03/15 06:00 [entrez]
PHST- 2016/03/15 06:00 [pubmed]
PHST- 2016/12/15 06:00 [medline]
AID - S0168-8227(16)00002-4 [pii]
AID - 10.1016/j.diabres.2015.12.001 [doi]
PST - ppublish
SO  - Diabetes Res Clin Pract. 2016 Mar;113:26-32. doi: 10.1016/j.diabres.2015.12.001. 
      Epub 2016 Jan 28.