PMID- 26973051
OWN - NLM
STAT- MEDLINE
DCOM- 20170427
LR  - 20180628
IS  - 1879-1891 (Electronic)
IS  - 0002-9394 (Linking)
VI  - 165
DP  - 2016 May
TI  - Spectral-Domain Optical Coherence Tomography-Derived Characteristics of Bruch 
      Membrane Opening in a Young Adult Australian Population.
PG  - 154-63
LID - S0002-9394(16)30100-3 [pii]
LID - 10.1016/j.ajo.2016.03.008 [doi]
AB  - PURPOSE: To characterize and quantify Bruch membrane opening (BMO)-based optic 
      nerve head (ONH) parameters in a large, young and healthy, predominantly white 
      population. DESIGN: Cross-sectional study and reliability analysis. METHODS: The 
      ONH of 1344 predominantly white subjects were imaged with spectral-domain optical 
      coherence tomography (SD-OCT). A customized script, coded in Matlab, was used to 
      manually segment and measure multiple BMO-based parameters of the ONH. 
      Measurements were compared to those obtained with confocal scanning laser 
      ophthalmoscopy (Heidelberg Retina Tomograph; HRT). Regression analysis was 
      performed to assess the relationship between BMO parameters and other ocular and 
      demographic variables. RESULTS: Mean BMO disc and neuroretinal rim (NRR) areas 
      ranged from 0.94 to 4.06 mm(2) (mean 1.77 +/- 0.38 mm(2)) and 0.94 to 3.99 mm(2) 
      (mean 1.56 +/- 0.31 mm(2)), respectively. When compared to the equivalent HRT 
      measurements, SD-OCT-derived measures differed significantly for all comparable 
      ONH parameters (P < .001). The limits of agreement computed from Bland-Altman 
      plots comparing SD-OCT and HRT measurements showed suboptimal agreement between 
      the techniques. Linear regression analysis demonstrated an effect of ethnicity, 
      axial length, and refractive error on BMO-based parameters. CONCLUSIONS: We have 
      quantified BMO-based parameters in a large cohort of young adults using SD-OCT. 
      These data will be informative in constructing normative profiles for clinical 
      and research purposes in glaucoma diagnosis and management.
CI  - Copyright (c) 2016 Elsevier Inc. All rights reserved.
FAU - Sanfilippo, Paul Gerard
AU  - Sanfilippo PG
AD  - Centre for Ophthalmology and Visual Science, University of Western Australia, 
      Lions Eye Institute, Perth, Australia; Centre for Eye Research Australia, 
      University of Melbourne, Royal Victorian Eye and Ear Hospital, East Melbourne, 
      Australia. Electronic address: prseye@gmail.com.
FAU - Huynh, Emily
AU  - Huynh E
AD  - Centre for Ophthalmology and Visual Science, University of Western Australia, 
      Lions Eye Institute, Perth, Australia.
FAU - Yazar, Seyhan
AU  - Yazar S
AD  - Centre for Ophthalmology and Visual Science, University of Western Australia, 
      Lions Eye Institute, Perth, Australia.
FAU - Hewitt, Alex William
AU  - Hewitt AW
AD  - Centre for Ophthalmology and Visual Science, University of Western Australia, 
      Lions Eye Institute, Perth, Australia; Centre for Eye Research Australia, 
      University of Melbourne, Royal Victorian Eye and Ear Hospital, East Melbourne, 
      Australia; School of Medicine, Menzies Research Institute Tasmania, University of 
      Tasmania, Hobart, Tasmania, Australia.
FAU - Mackey, David Anthony
AU  - Mackey DA
AD  - Centre for Ophthalmology and Visual Science, University of Western Australia, 
      Lions Eye Institute, Perth, Australia; Centre for Eye Research Australia, 
      University of Melbourne, Royal Victorian Eye and Ear Hospital, East Melbourne, 
      Australia; School of Medicine, Menzies Research Institute Tasmania, University of 
      Tasmania, Hobart, Tasmania, Australia.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20160310
PL  - United States
TA  - Am J Ophthalmol
JT  - American journal of ophthalmology
JID - 0370500
SB  - IM
CIN - Am J Ophthalmol. 2017 Feb;174:179. PMID: 27916202
CIN - Am J Ophthalmol. 2017 Feb;174:178-179. PMID: 27919401
MH  - Adolescent
MH  - Australia
MH  - Bruch Membrane/*anatomy & histology/diagnostic imaging
MH  - Cross-Sectional Studies
MH  - Female
MH  - Humans
MH  - Intraocular Pressure/physiology
MH  - Male
MH  - Nerve Fibers
MH  - Observer Variation
MH  - Ophthalmoscopy/methods
MH  - Optic Disk/*anatomy & histology/diagnostic imaging
MH  - Prospective Studies
MH  - Reference Values
MH  - Reproducibility of Results
MH  - Retinal Ganglion Cells/cytology
MH  - *Tomography, Optical Coherence
MH  - Visual Acuity/physiology
MH  - Young Adult
EDAT- 2016/03/15 06:00
MHDA- 2017/04/28 06:00
CRDT- 2016/03/15 06:00
PHST- 2015/12/08 00:00 [received]
PHST- 2016/03/03 00:00 [revised]
PHST- 2016/03/04 00:00 [accepted]
PHST- 2016/03/15 06:00 [entrez]
PHST- 2016/03/15 06:00 [pubmed]
PHST- 2017/04/28 06:00 [medline]
AID - S0002-9394(16)30100-3 [pii]
AID - 10.1016/j.ajo.2016.03.008 [doi]
PST - ppublish
SO  - Am J Ophthalmol. 2016 May;165:154-63. doi: 10.1016/j.ajo.2016.03.008. Epub 2016 
      Mar 10.