PMID- 26973274
OWN - NLM
STAT- MEDLINE
DCOM- 20160802
LR  - 20161126
IS  - 1349-3299 (Electronic)
IS  - 1349-2365 (Linking)
VI  - 57
IP  - 2
DP  - 2016
TI  - Biological Antioxidant Potential Negatively Correlates With Carotid Artery 
      Intima-Media Thickness.
PG  - 220-5
LID - 10.1536/ihj.15-389 [doi]
AB  - Oxidative stress is a crucial factor in the pathogenesis and development of 
      cardiovascular disease. Recently, simplified methods for the detection of 
      reactive oxygen species (ROS) using the derivatives of reactive oxygen 
      metabolites (d-ROMs) test as an index of ROS products and the biological 
      antioxidant potential (BAP) test as an index of antioxidant potential have been 
      utilized. These methods are easy to perform, quick, inexpensive since they use 
      small equipment, and provide reliable results compared with established oxidative 
      stress and antioxidant markers. Because oxidative stress has been shown to 
      represent the balance of production of ROS and antioxidant capacity, it is more 
      appropriate to evaluate ROS and antioxidant capacity simultaneously. However, no 
      study has examined the associations among d-ROMs, BAP values, and carotid artery 
      intima-media thickness (IMT) concurrently. Therefore, we studied the associations 
      among d-ROMs, BAP values, and the carotid artery IMT. Carotid artery IMT, blood 
      pressure (BP), fasting circulating d-ROMs, BAP, glucose metabolism, lipid, and 
      C-reactive protein levels were measured in 95 subjects (age: 49.5 +/- 13.8 years; 
      men: 41; women: 54), including 42 healthy subjects and 53 patients with 
      hypertension, dyslipidemia, and diabetes mellitus who were not on medication. The 
      results of multiple regression analysis revealed that dependent carotid artery 
      IMT determinants remained significantly associated with age, systolic BP, total 
      cholesterol, and BAP, whereas dependent BAP determinants remained significantly 
      associated with body mass index and carotid artery IMT. BAP was strongly 
      correlated with carotid artery IMT in our cohort. Our results suggest that BAP 
      may be a useful risk marker for carotid atherosclerosis.
FAU - Yagi, Hideki
AU  - Yagi H
AD  - Department of Clinical Laboratory Medicine, Gunma University Graduate School of 
      Medicine.
FAU - Sumino, Hiroyuki
AU  - Sumino H
FAU - Yoshida, Kensuke
AU  - Yoshida K
FAU - Aoki, Tomoyuki
AU  - Aoki T
FAU - Tsunekawa, Katsuhiko
AU  - Tsunekawa K
FAU - Araki, Osamu
AU  - Araki O
FAU - Kimura, Takao
AU  - Kimura T
FAU - Nara, Makoto
AU  - Nara M
FAU - Nakajima, Katsuyuki
AU  - Nakajima K
FAU - Murakami, Masami
AU  - Murakami M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20160311
PL  - Japan
TA  - Int Heart J
JT  - International heart journal
JID - 101244240
RN  - 0 (Antioxidants)
RN  - 0 (Reactive Oxygen Species)
RN  - 9007-41-4 (C-Reactive Protein)
SB  - IM
MH  - Antioxidants/*metabolism
MH  - Blood Pressure
MH  - Body Mass Index
MH  - C-Reactive Protein/*metabolism
MH  - Carotid Arteries/*diagnostic imaging/metabolism
MH  - Carotid Artery Diseases
MH  - *Carotid Intima-Media Thickness
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Oxidative Stress/*physiology
MH  - Reactive Oxygen Species/*metabolism
MH  - Risk Factors
EDAT- 2016/03/15 06:00
MHDA- 2016/08/03 06:00
CRDT- 2016/03/15 06:00
PHST- 2016/03/15 06:00 [entrez]
PHST- 2016/03/15 06:00 [pubmed]
PHST- 2016/08/03 06:00 [medline]
AID - 10.1536/ihj.15-389 [doi]
PST - ppublish
SO  - Int Heart J. 2016;57(2):220-5. doi: 10.1536/ihj.15-389. Epub 2016 Mar 11.