PMID- 26973447
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20160314
LR  - 20200929
IS  - 1662-4548 (Print)
IS  - 1662-453X (Electronic)
IS  - 1662-453X (Linking)
VI  - 10
DP  - 2016
TI  - Sexual Stimulation Increases the Survival of New Cells in the Accessory Olfactory 
      Bulb of the Male Rat.
PG  - 65
LID - 10.3389/fnins.2016.00065 [doi]
LID - 65
AB  - Sexual behavior in rodents is modulated by the olfactory system. The olfactory 
      bulb (OB) is a structure that undergoes continues neurogenesis in adulthood. We 
      have previously shown that 15 days after males rats pace the sexual interaction 
      and ejaculate 1 or 3 times, there is an increase in the density of new cells that 
      reach the accessory olfactory bulb (AOB). The aim of the present study was to 
      evaluate if sexual behavior in male rats increases the density of new neurons 
      that survive 45 days after sexual behavior in the AOB and in the main OB (MOB). 
      Male rats were randomly divided in four groups: (1) Control (Ctr), males without 
      sexual interaction; (2) Exposed (Exp), males only exposed to a sexually receptive 
      female; (3) No pacing (NP), males that mated in conditions in which the female 
      paced the sexual interaction; (4) One ejaculation (1E), males that paced the 
      sexual interaction with a receptive female and ejaculated once; and (5) Three 
      ejaculations (3E), males that paced the sexual interaction and were allowed to 
      ejaculate three times. All males were injected with the DNA synthesis marker 
      5-bromo-2-deoxyuridine (BrdU), and were tested in one of the above conditions. 45 
      days later they were sacrificed, and the OBs were processed to identify new cells 
      and evaluate if they had differentiated into neurons. Our data indicate that 
      males that ejaculated three times showed an increase in the density of new cells 
      that survive in the posterior part of the granular cell layer of the AOB and have 
      more new neurons that the control group. However, no significant differences were 
      found in the percentage of new cells that differentiate into neurons. No 
      significant increase in the density of new cells was observed in the MOB. Our 
      data show that pacing the sexual interaction until three ejaculations increases 
      the density of new cells and neurons in the granular layer of the AOB, confirming 
      that sexual behavior induces long-lasting plastic changes in the OB.
FAU - Unda, Nancy M
AU  - Unda NM
AD  - Neurobiologia Conductual y Cognitiva, Instituto de Neurobiologia, Universidad 
      Nacional Autonoma de Mexico Juriquilla, Mexico.
FAU - Portillo, Wendy
AU  - Portillo W
AD  - Neurobiologia Conductual y Cognitiva, Instituto de Neurobiologia, Universidad 
      Nacional Autonoma de Mexico Juriquilla, Mexico.
FAU - Corona, Rebeca
AU  - Corona R
AD  - Neurobiologia Conductual y Cognitiva, Instituto de Neurobiologia, Universidad 
      Nacional Autonoma de Mexico Juriquilla, Mexico.
FAU - Paredes, Raul G
AU  - Paredes RG
AD  - Neurobiologia Conductual y Cognitiva, Instituto de Neurobiologia, Universidad 
      Nacional Autonoma de Mexico Juriquilla, Mexico.
LA  - eng
PT  - Journal Article
DEP - 20160301
PL  - Switzerland
TA  - Front Neurosci
JT  - Frontiers in neuroscience
JID - 101478481
PMC - PMC4771754
OTO - NOTNLM
OT  - male rats
OT  - neurogenesis
OT  - neuronal plasticity
OT  - olfactory bulb
OT  - sexual behavior
EDAT- 2016/03/15 06:00
MHDA- 2016/03/15 06:01
PMCR- 2016/01/01
CRDT- 2016/03/15 06:00
PHST- 2015/11/11 00:00 [received]
PHST- 2016/02/10 00:00 [accepted]
PHST- 2016/03/15 06:00 [entrez]
PHST- 2016/03/15 06:00 [pubmed]
PHST- 2016/03/15 06:01 [medline]
PHST- 2016/01/01 00:00 [pmc-release]
AID - 10.3389/fnins.2016.00065 [doi]
PST - epublish
SO  - Front Neurosci. 2016 Mar 1;10:65. doi: 10.3389/fnins.2016.00065. eCollection 
      2016.