PMID- 26975037
OWN - NLM
STAT- MEDLINE
DCOM- 20170719
LR  - 20180814
IS  - 1532-0979 (Electronic)
IS  - 0147-5185 (Linking)
VI  - 40
IP  - 7
DP  - 2016 Jul
TI  - Renal Cell Carcinoma Occurring in Patients With Prior Neuroblastoma: A 
      Heterogenous Group of Neoplasms.
PG  - 989-97
LID - 10.1097/PAS.0000000000000632 [doi]
AB  - Renal cell carcinoma (RCC) associated with neuroblastoma (NB) was included as a 
      distinct entity in the 2004 World Health Organization classification of kidney 
      tumors. A spectrum of RCC subtypes has been reported in NB survivors. We herein 
      describe a series of 8 RCCs diagnosed in 7 patients with a history of NB. 
      Microscopic evaluation, immunohistochemical staining for PAX8, cathepsin K, and 
      succinate dehydrogenase subunit B (SDHB), and fluorescence in situ hybridization 
      (FISH) for TFE3 and TFEB were performed. Four distinct morphologic subtypes were 
      identified: 3 tumors were characterized by cells with abundant oncocytoid 
      cytoplasm and irregular nuclei; 3 showed features of microphthalmia transcription 
      factor family translocation RCC (MiTF-RCC); 1 had features of hybrid 
      oncocytic-chromophobe tumor; 1 had papillary RCC histology. All RCCs expressed 
      PAX8 and retained SDHB expression. Cathepsin K was positive in 2 MiTF-RCCs, 1 was 
      TFEB FISH positive, and the other was indeterminate. Cathepsin K was negative in 
      a third MiTF-RCC with TFE3 rearrangement. TFE3 FISH was negative in 4 and 
      insufficient in 1 of the other 5 RCCs. While a subset of RCCs associated with NB 
      is characterized by cells with prominent oncocytoid cytoplasm, other RCC subtypes 
      also occur in post-NB patients. Renal neoplasms occurring in patients with a 
      history of NB do not represent a single entity but a heterogenous group of RCCs. 
      SDHB mutations do not explain the subset of nontranslocation RCCs with oncocytoid 
      features; therefore, further studies are needed to clarify whether they may 
      represent a distinct entity with unique molecular abnormalities or may belong to 
      other emerging RCC subtypes.
FAU - Falzarano, Sara M
AU  - Falzarano SM
AD  - *Robert J. Tomsich Pathology and Laboratory Medicine Institute, Cleveland Clinic, 
      Cleveland, OH double dagger Department of Pathology and Laboratory Medicine, Indiana 
      University, Indianapolis, IN  section signDepartment of Pathology, Emory University School of 
      Medicine, Atlanta, GA  parallelDepartment of Pathology, Kaiser Permanente Panorama City 
      Medical Center, Panorama City  paragraph signDivision of Pathology, Children's Hospital Los 
      Angeles, Los Angeles, CA #Department of Pathology and Michigan Center for 
      Translational Pathology, University of Michigan, Ann Arbor, MI daggerSection of 
      Pathological Anatomy, University of Ancona, Ancona, Italy.
FAU - McKenney, Jesse K
AU  - McKenney JK
FAU - Montironi, Rodolfo
AU  - Montironi R
FAU - Eble, John N
AU  - Eble JN
FAU - Osunkoya, Adeboye O
AU  - Osunkoya AO
FAU - Guo, Juan
AU  - Guo J
FAU - Zhou, Shengmei
AU  - Zhou S
FAU - Xiao, Hong
AU  - Xiao H
FAU - Dhanasekaran, Saravana M
AU  - Dhanasekaran SM
FAU - Shukla, Sudhanshu
AU  - Shukla S
FAU - Mehra, Rohit
AU  - Mehra R
FAU - Magi-Galluzzi, Cristina
AU  - Magi-Galluzzi C
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Am J Surg Pathol
JT  - The American journal of surgical pathology
JID - 7707904
RN  - 0 (Biomarkers, Tumor)
SB  - IM
MH  - Biomarkers, Tumor/analysis
MH  - Carcinoma, Renal Cell/*pathology
MH  - Child
MH  - Child, Preschool
MH  - Cohort Studies
MH  - Female
MH  - Humans
MH  - Immunohistochemistry
MH  - In Situ Hybridization, Fluorescence
MH  - Infant
MH  - Kidney Neoplasms/*pathology
MH  - Male
MH  - Neoplasms, Second Primary/*pathology
MH  - Neuroblastoma/*pathology
MH  - Polymerase Chain Reaction
MH  - Survivors
EDAT- 2016/03/15 06:00
MHDA- 2017/07/20 06:00
CRDT- 2016/03/15 06:00
PHST- 2016/03/15 06:00 [entrez]
PHST- 2016/03/15 06:00 [pubmed]
PHST- 2017/07/20 06:00 [medline]
AID - 10.1097/PAS.0000000000000632 [doi]
PST - ppublish
SO  - Am J Surg Pathol. 2016 Jul;40(7):989-97. doi: 10.1097/PAS.0000000000000632.