PMID- 26976296
OWN - NLM
STAT- MEDLINE
DCOM- 20170306
LR  - 20181113
IS  - 1877-8755 (Electronic)
IS  - 1138-7548 (Linking)
VI  - 72
IP  - 2
DP  - 2016 Jun
TI  - Morin attenuates hepatic insulin resistance in high-fat-diet-induced obese mice.
PG  - 269-80
LID - 10.1007/s13105-016-0477-5 [doi]
AB  - Morin is a natural bioflavonoid that exhibits antioxidant and anti-inflammatory 
      properties. The present study was designed to evaluate the effect of morin on 
      insulin resistance, oxidative stress, and inflammation in a high-fat-diet 
      (HFD)-induced obese mice. Obesity was induced in ICR mice by feeding a HFD 
      (60 % kcal from fat) for 12 weeks. After the first 6 weeks, obese mice were 
      treated with morin (50 or 100 mg/kg/day) once daily for further 6 weeks. Blood 
      glucose, lipid profile, insulin, leptin, adiponectin, and markers of oxidative 
      stress and inflammation were then measured. Liver was excised, subjected to 
      histopathology, glycogen determination, and gene and protein expression analysis. 
      Morin administration reduced blood glucose, serum insulin, leptin, 
      malondialdehyde, interleukin-6 (IL-6), and monocyte chemoattractant protein-1 
      (MCP-1) levels and increased serum adiponectin levels. Moreover, there was a 
      reduction in serum lipid and liver triglyceride levels. Liver histology indicated 
      that morin limited accumulation of lipid droplets. Interestingly, morin reduced 
      expression of hepatic sterol regulatory element binding protein 1c (SREBP1c), 
      fatty acid synthase (FAS), and acetyl-CoA carboxylase (ACC) and up-regulated 
      hepatic carnitine palmitoyltransferase 1a (CPT1a) expression. Morin also 
      stimulated glycogen storage and suppressed phosphoenolpyruvate carboxykinase 
      (PEPCK) and glucose-6-phosphatase (G6Pase) protein expression. Furthermore, 
      hepatic superoxide dismutase (SOD) and catalase (CAT) expression were increased 
      after morin treatment. These findings indicate that morin has a positive effect 
      in the HFD-induced obesity condition by suppressing lipogenesis, gluconeogenesis, 
      inflammation, and oxidative stress activities.
FAU - Naowaboot, Jarinyaporn
AU  - Naowaboot J
AD  - Division of Pharmacology, Department of Preclinical Science, Faculty of Medicine, 
      Thammasat University (Rangsit Campus), Pathum Thani, 12120, Thailand. 
      naowaboot@yahoo.com.
FAU - Wannasiri, Supaporn
AU  - Wannasiri S
AD  - Division of Physiology, Department of Preclinical Science, Faculty of Medicine, 
      Thammasat University (Rangsit Campus), Pathum Thani, 12120, Thailand.
FAU - Pannangpetch, Patchareewan
AU  - Pannangpetch P
AD  - Department of Pharmacology, Faculty of Medicine, Khon Kaen University, Khon Kaen, 
      40002, Thailand.
LA  - eng
PT  - Journal Article
DEP - 20160314
PL  - Spain
TA  - J Physiol Biochem
JT  - Journal of physiology and biochemistry
JID - 9812509
RN  - 0 (Anti-Inflammatory Agents, Non-Steroidal)
RN  - 0 (Anti-Obesity Agents)
RN  - 0 (Antioxidants)
RN  - 0 (Biomarkers)
RN  - 0 (Flavonoids)
RN  - 8NFQ3F76WR (morin)
SB  - IM
MH  - Animals
MH  - Anti-Inflammatory Agents, Non-Steroidal/administration & dosage/*therapeutic use
MH  - Anti-Obesity Agents/administration & dosage
MH  - Antioxidants/administration & dosage/*therapeutic use
MH  - Biomarkers/blood/metabolism
MH  - Diet, High-Fat/adverse effects
MH  - Dose-Response Relationship, Drug
MH  - Flavonoids/administration & dosage/*therapeutic use
MH  - Gene Expression Regulation/drug effects
MH  - Gluconeogenesis/drug effects
MH  - Hyperglycemia/etiology/prevention & control
MH  - Hyperinsulinism/etiology/prevention & control
MH  - Hyperlipidemias/etiology/prevention & control
MH  - *Insulin Resistance
MH  - Lipid Peroxidation/drug effects
MH  - Lipogenesis/drug effects
MH  - Liver/*drug effects/immunology/metabolism/pathology
MH  - Male
MH  - Mice, Inbred ICR
MH  - Obesity/*drug therapy/immunology/metabolism/pathology
MH  - Oxidative Stress/drug effects
MH  - Weight Gain/drug effects
OTO - NOTNLM
OT  - Inflammation
OT  - Insulin resistance
OT  - Morin
OT  - Obesity
OT  - Oxidative stress
EDAT- 2016/03/16 06:00
MHDA- 2017/03/07 06:00
CRDT- 2016/03/16 06:00
PHST- 2015/09/16 00:00 [received]
PHST- 2016/03/03 00:00 [accepted]
PHST- 2016/03/16 06:00 [entrez]
PHST- 2016/03/16 06:00 [pubmed]
PHST- 2017/03/07 06:00 [medline]
AID - 10.1007/s13105-016-0477-5 [pii]
AID - 10.1007/s13105-016-0477-5 [doi]
PST - ppublish
SO  - J Physiol Biochem. 2016 Jun;72(2):269-80. doi: 10.1007/s13105-016-0477-5. Epub 
      2016 Mar 14.