PMID- 26978168
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20191120
IS  - 0040-3660 (Print)
IS  - 0040-3660 (Linking)
VI  - 87
IP  - 10
DP  - 2015
TI  - [Cardiovascular autonomic neuropathy in patients with type 2 diabetes mellitus 
      and coronary artery disease: Diagnosis and severity assessment].
PG  - 11-18
LID - 10.17116/terarkh2015871011-18 [doi]
AB  - AIM: To study the nature and severity of heart rate variability (HRV) and heart 
      rate turbulence (HRT) abnormalities in patients with coronary artery disease 
      (CAD) and type 2 diabetes mellitus (T2DM) and to assess the prevalence of 
      cardiovascular autonomic neuropathy (CAN) and its severity in patients with T2DM 
      concurrent with CAD. MATERIAL AND METHODS: A total of 185 patients with T2DM 
      and/or CAD were examined and divided into 3 groups: 1) 92 patients with CAD and 
      T2DM; 2) 43 patients with CAD without T2DM; 3) 49 patients with T2DM without CAD. 
      All the patients underwent 24-hour ECG monitoring with HRV and HRT analysis. 
      RESULTS: CAN was identified and the severity of CAN was assessed based on the 
      abnormal HRV and HRT parameters. CAN, especially severe one, was more common in 
      Group 1 (the relative risk was 3.3 [95% CI 1.3-8.2]; p<0.05), than in Group 3. In 
      Group 1, CAN was associated with the duration of T2DM and the level of glycated 
      hemoglobin (p<0.05). The patients with severe CAN in Group 1 showed a 4-fold 
      higher risk for multivessel coronary artery lesions than those without CAN 
      (p<0.05). CONCLUSION: Glycemic control quality, T2DM duration, and obvious 
      coronary atherosclerotic lesions were demonstrated to be associated with the 
      presence and severity of CAN. The developed methods may be used in practice to 
      detect and more accurately determine the severity of CAN and to predict 
      cardiovascular risk in patients with T2DM and CAD.
FAU - Beshlieva, D D
AU  - Beshlieva DD
AD  - Endocrinology Research Center, Ministry of Health of Russia, Moscow, Russia.
FAU - Kalashnikov, V Yu
AU  - Kalashnikov VY
AD  - Endocrinology Research Center, Ministry of Health of Russia, Moscow, Russia.
FAU - Smirnova, O M
AU  - Smirnova OM
AD  - Endocrinology Research Center, Ministry of Health of Russia, Moscow, Russia.
LA  - rus
PT  - English Abstract
PT  - Journal Article
TT  - Kardiovaskulyarnaya avtonomnaya nevropatiya u bol'nykh sakharnym diabetom 2-go 
      tipa i ishemicheskoi bolezn'yu serdtsa: diagnostika i otsenka tyazhesti.
PL  - Russia (Federation)
TA  - Ter Arkh
JT  - Terapevticheskii arkhiv
JID - 2984818R
SB  - IM
EDAT- 2015/01/01 00:00
MHDA- 2015/01/01 00:01
CRDT- 2016/03/16 06:00
PHST- 2016/03/16 06:00 [entrez]
PHST- 2015/01/01 00:00 [pubmed]
PHST- 2015/01/01 00:01 [medline]
AID - 10.17116/terarkh2015871011-18 [doi]
PST - ppublish
SO  - Ter Arkh. 2015;87(10):11-18. doi: 10.17116/terarkh2015871011-18.