PMID- 26978172
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20191120
IS  - 0040-3660 (Print)
IS  - 0040-3660 (Linking)
VI  - 87
IP  - 10
DP  - 2015
TI  - [Leptin, resistin, and hormonal and metabolic parameters in women with type 2 
      diabetes and in those with its concurrence with asthma].
PG  - 37-41
LID - 10.17116/terarkh2015871037-41 [doi]
AB  - AIM: To investigate the relationship between resistin, adiponectin, leptin, and 
      hormonal and metabolic parameters in patients with type 2 diabetes mellitus 
      (T2DM) and in those with its concurrence with asthma. MATERIAL AND METHODS: 
      Twenty-seven patients with T2DM and 26 patients with T2DM concurrent with asthma 
      were examined. The examination data of 23 apparently healthy women served as a 
      control. Anthropometric measurements, carbohydrate and lipid metabolic 
      parameters, and leptin, resistin, adiponectin, interleukin (IL)-6 and IL-10 
      levels were studied. RESULTS: Hyperleptinemia, hyperresistinemia, and lower 
      adiponectin concentrations were found in the patients with T2DM and in those with 
      its concurrence with asthma. These changes in the patients from these groups 
      occurred in the presence of subclinical inflammation. Obvious insulin resistance 
      (IR) accompanied by compensatory hyperinsulinemia was identified in the examined 
      women. The detected atherogenic dyslipidemia appeared as increases in the levels 
      of total cholesterol (C), triglycerides, low-density lipoprotein C, and 
      atherogenic index and as a decrease in those of high-density lipoprotein C. The 
      women with the concurrence of the diseases showed a positive correlation of the 
      level of resistin with insulin and the HOMA index. CONCLUSION: The patients with 
      T2DM and those with its concurrence with asthma exhibited obvious IR accompanied 
      by compensatory hyperinsulinemia. Hyperresistinemia plays a role in the 
      development of IR in the concurrence of these diseases. The patients with T2DM 
      and those with its concurrence with asthma were found to have hyperleptinemia, 
      hyperresistinemia, and a trend for decreasing adiponectin values in the presence 
      of subclinical inflammation.
FAU - Verbovoy, A F
AU  - Verbovoy AF
AD  - Samara State Medical University, Health Ministry of Russia, Samara, Russia.
FAU - Kosareva, O V
AU  - Kosareva OV
AD  - Samara State Medical University, Health Ministry of Russia, Samara, Russia.
FAU - Akhmerova, R I
AU  - Akhmerova RI
AD  - Samara State Medical University, Health Ministry of Russia, Samara, Russia.
LA  - rus
PT  - English Abstract
PT  - Journal Article
TT  - Leptin, rezistin i gormonal'no-metabolicheskie pokazateli u zhenshchin s 
      sakharnym diabetom 2-go tipa i pri ego sochetanii s bronkhial'noi astmoi.
PL  - Russia (Federation)
TA  - Ter Arkh
JT  - Terapevticheskii arkhiv
JID - 2984818R
SB  - IM
EDAT- 2015/01/01 00:00
MHDA- 2015/01/01 00:01
CRDT- 2016/03/16 06:00
PHST- 2016/03/16 06:00 [entrez]
PHST- 2015/01/01 00:00 [pubmed]
PHST- 2015/01/01 00:01 [medline]
AID - 10.17116/terarkh2015871037-41 [doi]
PST - ppublish
SO  - Ter Arkh. 2015;87(10):37-41. doi: 10.17116/terarkh2015871037-41.