PMID- 26978512
OWN - NLM
STAT- MEDLINE
DCOM- 20160428
LR  - 20181023
IS  - 1997-7298 (Print)
IS  - 1997-7298 (Linking)
VI  - 115
IP  - 12
DP  - 2015
TI  - [Low back pain: possibilities of pathogenetic treatment].
PG  - 162-168
LID - 10.17116/jnevro2015115112162-168 [doi]
AB  - Intervertebral disc (IVD) degeneration is one of the major causes of low back 
      pain (LBP). Due to the complexity of spinal pain syndromes, it is often difficult 
      to determine the extent of the IVD's contribution to the genesis of spinal pain. 
      Inflammatory response to IVD' injury has been acknowledged to be important in the 
      process of disc degeneration and may play an important role in pain generation. 
      In this article, the inflammatory mechanisms of LBP will be discussed with 
      special focus on interactions between inflammatory mediators and IVD 
      biomechanics. Tumor necrosis factor-alpha (TNF-alpha) is a key mediator of inflammatory 
      reactions in the pathogenesis of degenerative disk disease. The role of TNF-alpha 
      inhibitors as a potential target of therapeutic interventions in prevention of 
      neuronal damage and neuroprotection in LBP is discussed.
FAU - Tabeeva, G R
AU  - Tabeeva GR
AD  - Sechenov First Moscow State Medical University, Moscow.
LA  - rus
PT  - English Abstract
PT  - Journal Article
PT  - Review
PL  - Russia (Federation)
TA  - Zh Nevrol Psikhiatr Im S S Korsakova
JT  - Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova
JID - 9712194
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - Biomechanical Phenomena
MH  - Humans
MH  - Intervertebral Disc Degeneration/complications/*drug therapy
MH  - Low Back Pain/*drug therapy/*etiology/physiopathology
MH  - Tumor Necrosis Factor-alpha/*antagonists & inhibitors
EDAT- 2015/01/01 00:00
MHDA- 2016/04/29 06:00
CRDT- 2016/03/16 06:00
PHST- 2016/03/16 06:00 [entrez]
PHST- 2015/01/01 00:00 [pubmed]
PHST- 2016/04/29 06:00 [medline]
AID - 10.17116/jnevro2015115112162-168 [doi]
PST - ppublish
SO  - Zh Nevrol Psikhiatr Im S S Korsakova. 2015;115(12):162-168. doi: 
      10.17116/jnevro2015115112162-168.