PMID- 26978887
OWN - NLM
STAT- MEDLINE
DCOM- 20160415
LR  - 20240327
IS  - 2457-4325 (Print)
IS  - 2501-2533 (Electronic)
IS  - 2457-4325 (Linking)
VI  - 59
IP  - 3
DP  - 2015 Jul-Sep
TI  - NONICHEMIC CENTRAL RETINAL VEIN OCCLUSION ASSOCIATED WITH HEREDITARY 
      THROMBOPHYLIA.
PG  - 172-6
AB  - Retinal vein occlusion (RVO) is the second most common retinal vein disease with 
      significant visual loss via thrombus or compression of vein wall. Thrombophilia 
      is the predisposition to vascular thrombosis with the existence of genetic defect 
      that leads to blood hypercoagulability. This report describes the case of a 55 
      year old male patient, with an active life who presented himself at the emergency 
      room with acute visual lose, insidious and progressive visual field constriction, 
      without any known history of neurological or vascular diseases. The examinations 
      revealed unilateral optic nerve head edema, the fluorescein angiography was 
      specific for nonischemic central retinal vein occlusion CRVO complicated with 
      macular edema. Blood examinations has emphasized the presence of the heterozygous 
      mutation A1298C in the methylenetetrahydrofolate reductase gene (MTHFR), the only 
      one presented from the thrombophilia screen panel and a slightly elevated 
      cholesterol level. During the follow-up period, the patient received anti-VEGF 
      treatment (Bevacizumab, 3x 0.1 ml intravitreal injections) with improved visual 
      acuity and amendment of macular edema. The complex etiology calls for 
      interdisciplinary approach to determine better the cause of this ophthalmological 
      disease. Although studies have found a correlation between some thrombophilia 
      mutations and retinal vein occlusion, more studies that contain a larger number 
      of patients are necessary in order to determine the final role of these gene 
      variants.
FAU - Fisus, Andreea Dana
AU  - Fisus AD
FAU - Pop, Doina Suzana
AU  - Pop DS
FAU - Rusu, Monica Blanka
AU  - Rusu MB
FAU - Vultur, Florina
AU  - Vultur F
FAU - Horvath, Karin Ursula
AU  - Horvath KU
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - Romania
TA  - Rom J Ophthalmol
JT  - Romanian journal of ophthalmology
JID - 101677459
RN  - 0 (Angiogenesis Inhibitors)
RN  - 0 (Genetic Markers)
RN  - 2S9ZZM9Q9V (Bevacizumab)
RN  - EC 1.5.1.20 (MTHFR protein, human)
RN  - EC 1.5.1.20 (Methylenetetrahydrofolate Reductase (NADPH2))
SB  - IM
MH  - Angiogenesis Inhibitors/administration & dosage
MH  - Bevacizumab/administration & dosage
MH  - Diagnosis, Differential
MH  - Fluorescein Angiography/methods
MH  - Genetic Markers/genetics
MH  - Genotype
MH  - Heterozygote
MH  - Humans
MH  - Intravitreal Injections
MH  - Ischemia/diagnosis
MH  - Male
MH  - Methylenetetrahydrofolate Reductase (NADPH2)/*genetics
MH  - Middle Aged
MH  - *Mutation
MH  - Ophthalmoscopy/methods
MH  - Retinal Vein Occlusion/*diagnosis/drug therapy/*genetics
MH  - Thrombophilia/complications/*genetics
MH  - Treatment Outcome
MH  - Visual Field Tests/methods
PMC - PMC5712964
EDAT- 2016/03/17 06:00
MHDA- 2016/04/16 06:00
PMCR- 2015/08/01
CRDT- 2016/03/17 06:00
PHST- 2016/03/17 06:00 [entrez]
PHST- 2016/03/17 06:00 [pubmed]
PHST- 2016/04/16 06:00 [medline]
PHST- 2015/08/01 00:00 [pmc-release]
AID - RomJOphthalmol-59-172 [pii]
PST - ppublish
SO  - Rom J Ophthalmol. 2015 Jul-Sep;59(3):172-6.