PMID- 26980363 OWN - NLM STAT- MEDLINE DCOM- 20160516 LR - 20190610 IS - 2260-1341 (Print) IS - 2273-4309 (Electronic) IS - 2260-1341 (Linking) VI - 5 IP - 1 DP - 2016 TI - Genetic Moderators of the Impact of Physical Activity on Depressive Symptoms. PG - 6-14 LID - 10.14283/jfa.2016.76 [doi] AB - BACKGROUND: Converging evidence suggests that physical activity is an effective intervention for both clinical depression and sub-threshold depressive symptoms; however, findings are not always consistent. These mixed results might reflect heterogeneity in response to physical activity, with some subgroups of individuals responding positively, but not others. OBJECTIVES: 1) To examine the impact of genetic variation and sex on changes in depressive symptoms in older adults after a physical activity (PA) intervention, and 2) to determine if PA differentially improves particular symptom dimensions of depression. DESIGN: Randomized controlled trial. SETTING: Four field centers (Cooper Institute, Stanford University, University of Pittsburgh, and Wake Forest University). PARTICIPANTS: 396 community-dwelling adults aged 70-89 years who participated in the Lifestyle Interventions and Independence for Elders Pilot Study (LIFE-P). INTERVENTION: 12-month PA intervention compared to an education control. MEASUREMENTS: Polymorphisms in the serotonin transporter (5-HTT), brain-derived neurotrophic factor (BDNF), and apolipoprotein E (APOE) genes; 12-month change in the Center for Epidemiologic Studies Depression Scale total score, as well as scores on the depressed affect, somatic symptoms, and lack of positive affect subscales. RESULTS: Men randomized to the PA arm showed the greatest decreases in somatic symptoms, with a preferential benefit in male carriers of the BDNF Met allele. Symptoms of lack of positive affect decreased more in men compared to women, particularly in those possessing the 5-HTT L allele, but the effect did not differ by intervention arm. APOE status did not affect change in depressive symptoms. CONCLUSIONS: Results of this study suggest that the impact of PA on depressive symptoms varies by genotype and sex, and that PA may mitigate somatic symptoms of depression more than other symptoms. The results suggest that a targeted approach to recommending PA therapy for treatment of depression is viable. FAU - Dotson, V M AU - Dotson VM AD - Vonetta Dotson, Ph.D., Department of Clinical and Health, Psychology, University of Florida, P.O. Box 100165, Gainesville, FL 32610-0165, USA. Phone: +1 (352) 273-6041. Fax: +1 (352) 273-6156. Email: vonetta@phhp.ufl.edu. FAU - Hsu, F C AU - Hsu FC FAU - Langaee, T Y AU - Langaee TY FAU - McDonough, C W AU - McDonough CW FAU - King, A C AU - King AC FAU - Cohen, R A AU - Cohen RA FAU - Newman, A B AU - Newman AB FAU - Kritchevsky, S B AU - Kritchevsky SB FAU - Myers, V AU - Myers V FAU - Manini, T M AU - Manini TM FAU - Pahor, M AU - Pahor M CN - LIFE STUDY GROUP LA - eng SI - ClinicalTrials.gov/NCT00116194 GR - P30 AG024827/AG/NIA NIH HHS/United States GR - P30 AG028740-01/AG/NIA NIH HHS/United States GR - P30 AG028740/AG/NIA NIH HHS/United States GR - Intramural NIH HHS/United States GR - UL1 TR001427/TR/NCATS NIH HHS/United States GR - K24AG021507/AG/NIA NIH HHS/United States GR - U01AG22376/AG/NIA NIH HHS/United States GR - KL2 TR001429/TR/NCATS NIH HHS/United States GR - K24 AG021507/AG/NIA NIH HHS/United States GR - 1 P30 AG21332/AG/NIA NIH HHS/United States GR - U01 AG022376/AG/NIA NIH HHS/United States GR - P30 AG021332/AG/NIA NIH HHS/United States PT - Journal Article PT - Multicenter Study PT - Randomized Controlled Trial PT - Research Support, N.I.H., Extramural PT - Research Support, N.I.H., Intramural PL - France TA - J Frailty Aging JT - The Journal of frailty & aging JID - 101604797 RN - 0 (Apolipoproteins E) RN - 0 (Brain-Derived Neurotrophic Factor) RN - 0 (SLC6A4 protein, human) RN - 0 (Serotonin Plasma Membrane Transport Proteins) RN - 7171WSG8A2 (BDNF protein, human) SB - IM MH - Aged MH - Aged, 80 and over MH - Apolipoproteins E/*genetics MH - Brain-Derived Neurotrophic Factor/*genetics MH - *Depression/diagnosis/genetics/physiopathology/therapy MH - Exercise Therapy/*methods MH - Female MH - Humans MH - Independent Living/psychology MH - *Life Style MH - Male MH - *Motor Activity/genetics/physiology MH - Polymorphism, Genetic MH - Psychiatric Status Rating Scales MH - Serotonin Plasma Membrane Transport Proteins/*genetics MH - Sex Factors MH - Treatment Outcome PMC - PMC4905714 MID - NIHMS758551 COIS- The authors have no conflicts of interest to report. FIR - Blair, Steven N IR - Blair SN FIR - Church, Timothy IR - Church T FIR - Ashmore, Jamile A IR - Ashmore JA FIR - Dubreuil, Judy IR - Dubreuil J FIR - Frierson, Georita IR - Frierson G FIR - Jordan, Alexander N IR - Jordan AN FIR - Morss, Gina IR - Morss G FIR - Rodarte, Ruben Q IR - Rodarte RQ FIR - Wallace, Jason M IR - Wallace JM FIR - Guralnik, Jack M IR - Guralnik JM FIR - Hadley, Evan C IR - Hadley EC FIR - Romashkan, Sergei IR - Romashkan S FIR - King, Abby C IR - King AC FIR - Haskell, William L IR - Haskell WL FIR - Pruitt, Leslie A IR - Pruitt LA FIR - Abbott-Pilolla, Kari IR - Abbott-Pilolla K FIR - Bolen, Karen IR - Bolen K FIR - Fortmann, Stephen IR - Fortmann S FIR - Laws, Ami IR - Laws A FIR - Prosak, Carolyn IR - Prosak C FIR - Wallace, Kristin IR - Wallace K FIR - Fielding, Roger IR - Fielding R FIR - Nelson, Miriam IR - Nelson M FIR - Kaplan, Robert M IR - Kaplan RM FIR - Groessl, Erik J IR - Groessl EJ FIR - Pahor, Marco IR - Pahor M FIR - Perri, Michael IR - Perri M FIR - Caudle, Connie IR - Caudle C FIR - Crump, Lauren IR - Crump L FIR - Hayden, Sarah IR - Hayden S FIR - Holmes, Latonia IR - Holmes L FIR - Maraldi, Cinzia IR - Maraldi C FIR - Quirin, Crystal IR - Quirin C FIR - Newman, Anne B IR - Newman AB FIR - Studenski, Stephanie IR - Studenski S FIR - Goodpaster, Bret H IR - Goodpaster BH FIR - Glynn, Nancy W IR - Glynn NW FIR - Aiken, Erin K IR - Aiken EK FIR - Anthony, Steve IR - Anthony S FIR - Beck, Sarah IR - Beck S FIR - Kadosh, Judith IR - Kadosh J FIR - Kost, Piera IR - Kost P FIR - Newman, Mark IR - Newman M FIR - Rush, Jennifer IR - Rush J FIR - Spanos, Roberta IR - Spanos R FIR - Taylor, Christopher A IR - Taylor CA FIR - Vincent, Pam IR - Vincent P FIR - Ives, Diane IR - Ives D FIR - Kritchevsky, Stephen B IR - Kritchevsky SB FIR - Brubaker, Peter IR - Brubaker P FIR - Demons, Jamehl IR - Demons J FIR - Furberg, Curt IR - Furberg C FIR - Katula, Jeffrey A IR - Katula JA FIR - March, Anthony IR - March A FIR - Nicklas, Barbara J IR - Nicklas BJ FIR - Williamson, Jeff D IR - Williamson JD FIR - Fries, Rose IR - Fries R FIR - Kennedy, Kimberly IR - Kennedy K FIR - Murphy, Karin M IR - Murphy KM FIR - Nagaria, Shruti IR - Nagaria S FIR - Wickley-Krupel, Katie IR - Wickley-Krupel K FIR - Miller, Michael E IR - Miller ME FIR - Espeland, Mark IR - Espeland M FIR - Hsu, Fang-Chi IR - Hsu FC FIR - Rejeski, Walter J IR - Rejeski WJ FIR - Babcock, Don P Jr IR - Babcock DP Jr FIR - Costanza, Lorraine IR - Costanza L FIR - Harvin, Lea N IR - Harvin LN FIR - Kaltenbach, Lisa IR - Kaltenbach L FIR - Lang, Wei IR - Lang W FIR - Roberson, Wesley A IR - Roberson WA FIR - Rushing, Julia IR - Rushing J FIR - Rushing, Scott IR - Rushing S FIR - Walkup, Michael P IR - Walkup MP EDAT- 2016/03/17 06:00 MHDA- 2016/05/18 06:00 PMCR- 2016/06/13 CRDT- 2016/03/17 06:00 PHST- 2016/03/17 06:00 [entrez] PHST- 2016/03/17 06:00 [pubmed] PHST- 2016/05/18 06:00 [medline] PHST- 2016/06/13 00:00 [pmc-release] AID - 10.14283/jfa.2016.76 [doi] PST - ppublish SO - J Frailty Aging. 2016;5(1):6-14. doi: 10.14283/jfa.2016.76.