PMID- 26980386
OWN - NLM
STAT- MEDLINE
DCOM- 20161223
LR  - 20161230
IS  - 1945-8932 (Electronic)
IS  - 1945-8932 (Linking)
VI  - 30
IP  - 2
DP  - 2016 Mar-Apr
TI  - The association between serum lead and total immunoglobulin E levels according to 
      allergic sensitization.
PG  - e48-52
LID - 10.2500/ajra.2016.30.4302 [doi]
AB  - BACKGROUND: Results of several studies showed that blood lead concentration is 
      positively associated with total immunoglobulin E (IgE) value. However, no study 
      has investigated whether allergic sensitization could be responsible for the 
      association between lead exposure and total IgE value. OBJECTIVE: We investigated 
      whether there was difference in the association between lead exposure and the 
      total IgE value, depending on the presence or absence of Dermatophagoides farinae 
      sensitization. METHODS: We used data obtained from the Korea National Health and 
      Nutrition Examination Survey. Serum levels of heavy metals, such as mercury, 
      cadmium, and lead, were measured. Total and D. farinae specific IgE levels were 
      measured, and the urinary cotinine level was investigated. Information about sex, 
      age, body mass index, and household income were also obtained. We analyzed the 
      association between serum lead and total IgE levels, after adjusting other 
      variables. RESULTS: In an multivariate linear regression analysis, only the serum 
      concentration of lead among the three heavy metals was positively associated with 
      logarithmic transformed total IgE (coefficient [B], 0.026 [95% confidence 
      interval CI], 0.008-0.044). When we performed the same analysis on groups 
      divided by allergic D. farinae sensitization status, we found a significant 
      positive association between serum lead and logarithmic transformed total IgE 
      values in subjects with D. farinae sensitization (B, 0.043 [95% CI, 0.014-0.071]) 
      but not in subjects without D. farinae sensitization (B, 0.015 [95% CI, -0.008 to 
      0.039]). CONCLUSIONS: A positive association between the serum lead and total IgE 
      levels was statistically significant in subjects with D. farinae sensitization, 
      which indicated that the immunologic effects of lead exposure may be greater in 
      people with allergic sensitization.
FAU - Kim, Jeong Hong
AU  - Kim JH
AD  - 1Department of Otorhinolaryngology, Jeju National University School of Medicine, 
      Jeju, Korea.
FAU - Chang, Jung Hyun
AU  - Chang JH
FAU - Choi, Hyun Seung
AU  - Choi HS
FAU - Kim, Hyun Jik
AU  - Kim HJ
FAU - Kang, Ju Wan
AU  - Kang JW
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Am J Rhinol Allergy
JT  - American journal of rhinology & allergy
JID - 101490775
RN  - 0 (Antigens, Dermatophagoides)
RN  - 2P299V784P (Lead)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - K5161X06LL (Cotinine)
SB  - IM
MH  - Adult
MH  - Animals
MH  - Antigens, Dermatophagoides/immunology
MH  - Cotinine/urine
MH  - Dermatophagoides farinae
MH  - Environmental Exposure/adverse effects
MH  - Female
MH  - Humans
MH  - Hypersensitivity/*immunology
MH  - Immunization
MH  - Immunoglobulin E/blood/*immunology
MH  - Lead/adverse effects/blood/*immunology
MH  - Male
MH  - Middle Aged
MH  - Republic of Korea
EDAT- 2016/03/17 06:00
MHDA- 2016/12/24 06:00
CRDT- 2016/03/17 06:00
PHST- 2016/03/17 06:00 [entrez]
PHST- 2016/03/17 06:00 [pubmed]
PHST- 2016/12/24 06:00 [medline]
AID - 10.2500/ajra.2016.30.4302 [doi]
PST - ppublish
SO  - Am J Rhinol Allergy. 2016 Mar-Apr;30(2):e48-52. doi: 10.2500/ajra.2016.30.4302.