PMID- 26981778
OWN - NLM
STAT- MEDLINE
DCOM- 20180130
LR  - 20181202
IS  - 1949-2553 (Electronic)
IS  - 1949-2553 (Linking)
VI  - 7
IP  - 17
DP  - 2016 Apr 26
TI  - ABCG1 maintains high-grade glioma survival in vitro and in vivo.
PG  - 23416-24
LID - 10.18632/oncotarget.8030 [doi]
AB  - The overall survival for adults with malignant glioma (glioblastoma) remains poor 
      despite advances in radiation and chemotherapy. One of the mechanisms by which 
      cancer cells develop relative resistance to treatment is through de-regulation of 
      endoplasmic reticulum (ER) homeostasis. We have recently shown that ABCG1, an 
      ATP-binding cassette transporter, maintains ER homeostasis and suppresses ER 
      stress-induced apoptosis in low-grade glioma. Herein, we demonstrate that ABCG1 
      expression is increased in human adult glioblastoma, where it correlates with 
      poor survival in individuals with the mesenchymal subtype. Leveraging a mouse 
      model of mesenchymal glioblastoma (NPcis), shRNA-mediated Abcg1 knockdown (KD) 
      increased CHOP ER stress protein expression and resulted in greater NPcis glioma 
      cell death in vitro. Moreover, Abcg1 KD reduced NPcis glioma growth and increased 
      mouse survival in vivo. Collectively, these results demonstrate that ABCG1 is 
      critical for malignant glioma cell survival, and might serve as a future 
      therapeutic target for these deadly brain cancers.
FAU - Chen, Yi-Hsien
AU  - Chen YH
AD  - Department of Neurology, Washington University School of Medicine, St. Louis, MO, 
      USA.
FAU - Cimino, Patrick J
AU  - Cimino PJ
AD  - Department of Pathology, Washington University School of Medicine, St. Louis, MO, 
      USA.
FAU - Luo, Jingqin
AU  - Luo J
AD  - Department of Surgery, Washington University School of Medicine, St. Louis, MO, 
      USA.
FAU - Dahiya, Sonika
AU  - Dahiya S
AD  - Department of Pathology, Washington University School of Medicine, St. Louis, MO, 
      USA.
FAU - Gutmann, David H
AU  - Gutmann DH
AD  - Department of Neurology, Washington University School of Medicine, St. Louis, MO, 
      USA.
LA  - eng
GR  - P30 CA091842/CA/NCI NIH HHS/United States
GR  - P50 CA094056/CA/NCI NIH HHS/United States
GR  - R01 NS065547/NS/NINDS NIH HHS/United States
PT  - Journal Article
PL  - United States
TA  - Oncotarget
JT  - Oncotarget
JID - 101532965
RN  - 0 (ABCG1 protein, human)
RN  - 0 (ATP Binding Cassette Transporter, Subfamily G, Member 1)
RN  - 0 (Biomarkers, Tumor)
SB  - IM
MH  - ATP Binding Cassette Transporter, Subfamily G, Member 1/*metabolism
MH  - Adult
MH  - Animals
MH  - Apoptosis
MH  - Biomarkers, Tumor/*metabolism
MH  - Brain Neoplasms/metabolism/*pathology
MH  - Case-Control Studies
MH  - Cell Proliferation
MH  - Follow-Up Studies
MH  - Glioma/metabolism/*pathology
MH  - Humans
MH  - Male
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Neoplasm Grading
MH  - Survival Rate
MH  - Tumor Cells, Cultured
MH  - Xenograft Model Antitumor Assays
PMC - PMC5029636
OTO - NOTNLM
OT  - ER stress
OT  - apoptosis
OT  - brain tumor
OT  - glioblastoma
OT  - glioma stem cell
COIS- None to disclose.
EDAT- 2016/03/17 06:00
MHDA- 2018/01/31 06:00
PMCR- 2016/04/26
CRDT- 2016/03/17 06:00
PHST- 2015/09/29 00:00 [received]
PHST- 2016/02/25 00:00 [accepted]
PHST- 2016/03/17 06:00 [entrez]
PHST- 2016/03/17 06:00 [pubmed]
PHST- 2018/01/31 06:00 [medline]
PHST- 2016/04/26 00:00 [pmc-release]
AID - 8030 [pii]
AID - 10.18632/oncotarget.8030 [doi]
PST - ppublish
SO  - Oncotarget. 2016 Apr 26;7(17):23416-24. doi: 10.18632/oncotarget.8030.