PMID- 26981838
OWN - NLM
STAT- MEDLINE
DCOM- 20161230
LR  - 20220409
IS  - 1557-7430 (Electronic)
IS  - 1044-5498 (Linking)
VI  - 35
IP  - 6
DP  - 2016 Jun
TI  - Long Noncoding RNA Highly Upregulated in Liver Cancer Regulates the Tumor 
      Necrosis Factor-alpha-Induced Apoptosis in Human Vascular Endothelial Cells.
PG  - 296-300
LID - 10.1089/dna.2015.3203 [doi]
AB  - Atherosclerosis is the major cause of myocardial infarction and stroke, which is 
      a leading cause of morbidity and mortality in developed countries. During the 
      pathological process of atherosclerosis, inflammation participates in all stages 
      of atherosclerosis. Tumor necrosis factor-alpha (TNF-alpha), one of the most important 
      inflammatory factor, induces apoptosis of endothelial cells, which play a central 
      role in endothelial dysfunction. However, the underlying mechanism involved in 
      long noncoding RNA (lncRNA) remains unclear. In the present study, we 
      demonstrated the role of lncRNA highly upregulated in liver cancer (HULC) in 
      TNF-alpha-induced apoptosis. HULC expression was decreased with TNF-alpha treatment. 
      Restoring HULC expression rescued the apoptosis induced by TNF-alpha. HULC regulated 
      TNF-alpha-induced apoptosis through regulation of miR-9 expression. Furthermore, RNA 
      immunoprecipitation and RNA pull-down assays showed that HULC modulated miR-9 
      expression through association with DNA methyltransferases and suppression of 
      miR-9 expression. HULC-miR-9 pathway may be a potential target for treating 
      atherosclerosis.
FAU - Ma, Yongjiang
AU  - Ma Y
AD  - Department of Cardiology, First Affiliated Hospital of General Hospital of 
      Chinese People's Liberation Army , Beijing, China .
FAU - Huang, Dangsheng
AU  - Huang D
AD  - Department of Cardiology, First Affiliated Hospital of General Hospital of 
      Chinese People's Liberation Army , Beijing, China .
FAU - Yang, Feifei
AU  - Yang F
AD  - Department of Cardiology, First Affiliated Hospital of General Hospital of 
      Chinese People's Liberation Army , Beijing, China .
FAU - Tian, Miao
AU  - Tian M
AD  - Department of Cardiology, First Affiliated Hospital of General Hospital of 
      Chinese People's Liberation Army , Beijing, China .
FAU - Wang, Yumei
AU  - Wang Y
AD  - Department of Cardiology, First Affiliated Hospital of General Hospital of 
      Chinese People's Liberation Army , Beijing, China .
FAU - Shen, Dong
AU  - Shen D
AD  - Department of Cardiology, First Affiliated Hospital of General Hospital of 
      Chinese People's Liberation Army , Beijing, China .
FAU - Wang, Qiushuang
AU  - Wang Q
AD  - Department of Cardiology, First Affiliated Hospital of General Hospital of 
      Chinese People's Liberation Army , Beijing, China .
FAU - Chen, Qiang
AU  - Chen Q
AD  - Department of Cardiology, First Affiliated Hospital of General Hospital of 
      Chinese People's Liberation Army , Beijing, China .
FAU - Zhang, Liwei
AU  - Zhang L
AD  - Department of Cardiology, First Affiliated Hospital of General Hospital of 
      Chinese People's Liberation Army , Beijing, China .
LA  - eng
PT  - Journal Article
DEP - 20160316
PL  - United States
TA  - DNA Cell Biol
JT  - DNA and cell biology
JID - 9004522
RN  - 0 (HULC long non-coding RNA, human)
RN  - 0 (MIRN92 microRNA, human)
RN  - 0 (MicroRNAs)
RN  - 0 (RNA, Long Noncoding)
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - Apoptosis
MH  - Atherosclerosis/immunology/*metabolism
MH  - CpG Islands
MH  - DNA Methylation
MH  - Human Umbilical Vein Endothelial Cells
MH  - Humans
MH  - MicroRNAs/*genetics
MH  - Promoter Regions, Genetic
MH  - RNA, Long Noncoding/*metabolism
MH  - Tumor Necrosis Factor-alpha/metabolism
EDAT- 2016/03/17 06:00
MHDA- 2016/12/31 06:00
CRDT- 2016/03/17 06:00
PHST- 2016/03/17 06:00 [entrez]
PHST- 2016/03/17 06:00 [pubmed]
PHST- 2016/12/31 06:00 [medline]
AID - 10.1089/dna.2015.3203 [doi]
PST - ppublish
SO  - DNA Cell Biol. 2016 Jun;35(6):296-300. doi: 10.1089/dna.2015.3203. Epub 2016 Mar 
      16.