PMID- 26985678
OWN - NLM
STAT- MEDLINE
DCOM- 20161229
LR  - 20220318
IS  - 1791-2431 (Electronic)
IS  - 1021-335X (Linking)
VI  - 35
IP  - 5
DP  - 2016 May
TI  - Strong inflammatory response and Th1-polarization profile in children with acute 
      lymphoblastic leukemia without apparent infection.
PG  - 2699-706
LID - 10.3892/or.2016.4657 [doi]
AB  - Children with acute lymphoblastic leukemia (ALL) often present fever. Febrile 
      states are usually associated with infectious processes that generate an 
      inflammatory response involving various molecules, including cytokines. However, 
      an inflammatory response may also occur in the absence of infection. We 
      hypothesized that the levels of inflammatory cytokines are increased in children 
      with ALL without apparent infection. The serum levels of 13 cytokines in 99 
      patients with ALL and 48 non-oncological patients without apparent infection were 
      measured using multiplex analyte profiling technology (Luminex(R)). The 
      concentration of circulating pro-inflammatory cytokines associated with fever was 
      similar between patients with ALL and fever at diagnosis and those without fever. 
      The levels of tumor necrosis factor alpha, interleukin (IL)-6, IL-8, monocyte 
      chemoattractant protein-1 (MCP-1) and IL-10 were higher in patients with ALL vs. 
      the control group (P<0.05). Moreover, the levels of the T helper 1 (interferon‑gamma 
      and IL-12) cytokines were higher in patients with ALL vs. the control group. 
      Transforming growth factor beta was lower in patients with ALL vs. the control group 
      (P<0.05). The levels of IL-1beta, IL-2, IL-4, IL-13, and IL-17 were similar in the 
      two groups. Our results indicate that the circulating levels of seven of the 
      important studied cytokines are elevated in patients with newly diagnosed ALL 
      without apparent infection, reflecting a strong and deregulated inflammatory 
      state in this disease, with a Th1-polarization profile.
FAU - Perez-Figueroa, E
AU  - Perez-Figueroa E
AD  - Immunology and Proteomics Research Laboratory, Children's Hospital of Mexico 
      Federico Gomez, Mexico, D.F., Mexico.
FAU - Sanchez-Cuaxospa, M
AU  - Sanchez-Cuaxospa M
AD  - Immunology and Proteomics Research Laboratory, Children's Hospital of Mexico 
      Federico Gomez, Mexico, D.F., Mexico.
FAU - Martinez-Soto, K A
AU  - Martinez-Soto KA
AD  - Immunology and Proteomics Research Laboratory, Children's Hospital of Mexico 
      Federico Gomez, Mexico, D.F., Mexico.
FAU - Sanchez-Zauco, N
AU  - Sanchez-Zauco N
AD  - Immunology and Proteomics Research Laboratory, Children's Hospital of Mexico 
      Federico Gomez, Mexico, D.F., Mexico.
FAU - Medina-Sanson, A
AU  - Medina-Sanson A
AD  - Department of Hematology-Oncology, Children's Hospital of Mexico Federico Gomez, 
      Mexico, D.F., Mexico.
FAU - Jimenez-Hernandez, E
AU  - Jimenez-Hernandez E
AD  - Oncology Service, Children's Hospital Moctezuma, Mexico, D.F., Mexico.
FAU - Torres-Nava, J R
AU  - Torres-Nava JR
AD  - Oncology Service, Children's Hospital Moctezuma, Mexico, D.F., Mexico.
FAU - Felix-Castro, J M
AU  - Felix-Castro JM
AD  - Oncology Service, Highly Specialized Unit, General Hospital National Medical 
      Center La Raza, Mexican Institute of Social Security, Mexico, D.F., Mexico.
FAU - Gomez, A
AU  - Gomez A
AD  - Research Unit on Infectious Diseases, Pediatric Hospital, National Medical Center 
      XXI Century, Mexican Institute of Social Security, Mexico, D.F., Mexico.
FAU - Ortega, E
AU  - Ortega E
AD  - Department of Immunology, Institute for Biomedical Research, National Autonomous 
      University of Mexico, Mexico, D.F., Mexico.
FAU - Maldonado-Bernal, C
AU  - Maldonado-Bernal C
AD  - Immunology and Proteomics Research Laboratory, Children's Hospital of Mexico 
      Federico Gomez, Mexico, D.F., Mexico.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20160307
PL  - Greece
TA  - Oncol Rep
JT  - Oncology reports
JID - 9422756
RN  - 0 (Chemokines)
SB  - IM
MH  - Adolescent
MH  - Cell Polarity
MH  - Chemokines/blood
MH  - Child
MH  - Child, Preschool
MH  - Female
MH  - Fever/blood/immunology
MH  - Humans
MH  - Infant
MH  - Male
MH  - Precursor Cell Lymphoblastic Leukemia-Lymphoma/blood/*immunology
MH  - Th1 Cells/*physiology
EDAT- 2016/03/18 06:00
MHDA- 2016/12/31 06:00
CRDT- 2016/03/18 06:00
PHST- 2015/11/06 00:00 [received]
PHST- 2015/12/17 00:00 [accepted]
PHST- 2016/03/18 06:00 [entrez]
PHST- 2016/03/18 06:00 [pubmed]
PHST- 2016/12/31 06:00 [medline]
AID - 10.3892/or.2016.4657 [doi]
PST - ppublish
SO  - Oncol Rep. 2016 May;35(5):2699-706. doi: 10.3892/or.2016.4657. Epub 2016 Mar 7.