PMID- 26985801
OWN - NLM
STAT- MEDLINE
DCOM- 20161213
LR  - 20161230
IS  - 2325-8179 (Electronic)
IS  - 2325-8160 (Linking)
VI  - 47
IP  - 3
DP  - 2016 Mar
TI  - Multi-Modal Longitudinal Evaluation of Subthreshold Laser Lesions in Human 
      Retina, Including Scanning Laser Ophthalmoscope-Adaptive Optics Imaging.
PG  - 268-75
LID - 10.3928/23258160-20160229-10 [doi]
AB  - BACKGROUND AND OBJECTIVE: Subthreshold retinal laser therapy is efficacious for a 
      variety of retinovascular disorders. Currently, it is unknown which laser 
      parameters can ensure no detectable damage to human retina tissue. MATERIALS AND 
      METHODS: One informed physician participant with a normal retina was treated with 
      three levels (75%, 50%, and 25%) of subthreshold 577-nm laser (PASCAL; Topcon, 
      Santa Clara, CA) at 20-millisecond (ms) duration and 100 microm spot size. Several 
      high-resolution retinal imaging modalities, including spectral-domain optical 
      coherence tomography (SD-OCT) and scanning laser ophthalmoscope-adaptive optics 
      (SLO-AO), were used to longitudinally image retinal laser lesions during a 
      9-month period. RESULTS: SLO-AO and SD-OCT imaging of subthreshold laser therapy 
      in human retina showed no cone cell or RPE damage at all time points during a 
      9-month period using the 25% threshold power 577-nm laser in the human retina. 
      CONCLUSION: It is likely that subthreshold laser therapy with 577-nm laser at 
      20-ms duration in the human retina is safe at the 25% of threshold power level.
CI  - Copyright 2016, SLACK Incorporated.
FAU - Wood, Edward H
AU  - Wood EH
FAU - Leng, Theodore
AU  - Leng T
FAU - Schachar, Ira H
AU  - Schachar IH
FAU - Karth, Peter A
AU  - Karth PA
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Ophthalmic Surg Lasers Imaging Retina
JT  - Ophthalmic surgery, lasers & imaging retina
JID - 101599215
SB  - IM
MH  - Fluorescein Angiography
MH  - Humans
MH  - Laser Coagulation/instrumentation
MH  - Lasers, Semiconductor/*adverse effects
MH  - Multimodal Imaging
MH  - Ophthalmoscopes
MH  - Photoreceptor Cells, Vertebrate/*pathology
MH  - Retina/*injuries
MH  - Retinal Diseases/*diagnostic imaging
MH  - Tomography, Optical Coherence
EDAT- 2016/03/18 06:00
MHDA- 2016/12/15 06:00
CRDT- 2016/03/18 06:00
PHST- 2015/08/29 00:00 [received]
PHST- 2016/01/21 00:00 [accepted]
PHST- 2016/03/18 06:00 [entrez]
PHST- 2016/03/18 06:00 [pubmed]
PHST- 2016/12/15 06:00 [medline]
AID - 10.3928/23258160-20160229-10 [doi]
PST - ppublish
SO  - Ophthalmic Surg Lasers Imaging Retina. 2016 Mar;47(3):268-75. doi: 
      10.3928/23258160-20160229-10.