PMID- 26985913
OWN - NLM
STAT- MEDLINE
DCOM- 20170623
LR  - 20211204
IS  - 1952-4013 (Electronic)
IS  - 1167-1122 (Linking)
VI  - 26
IP  - 3
DP  - 2016 Jun 1
TI  - Epithelial skin cancers after kidney transplantation: a retrospective 
      single-centre study of 376 recipients.
PG  - 265-70
LID - 10.1684/ejd.2016.2758 [doi]
AB  - Post-transplant non-melanoma skin cancers (NMSC) are the most common malignancies 
      in kidney transplant recipients. To analyse risk factors associated with the 
      occurrence of basal cell carcinomas (BBC) and squamous cell carcinomas (SCC) in 
      kidney transplant recipients. Statistical analysis was performed on 376 kidney 
      transplant recipients screened for NMSC in 2002-2009 and followed until 2013. 
      NMSC developed in 23.67% of individuals with an SCC/BCC ratio of 2.15:1 and an 
      age-standardised incidence ratio (IR) of 2.71 cases (95% CI: 1.97-3.46) per 100 
      patients/year. Based on multivariable analysis, NMSC occurrence significantly 
      correlated with higher age (p<0.001), fair skin type (p = 0.01), and particularly 
      SCCs with male gender (p = 0.001). Patients with >10 actinic keratoses were at 
      higher risk of developing NMSCs (IRR = 2.95; 95% CI: 1.97-4.42; p<0.001) and more 
      prone to SCCs, compared to BCCs (p = 0.04). Also, more SCC carriers had high 
      counts of warty lesions (p = 0.006). Calcineurin inhibitors were associated with 
      higher NMSC incidence (IRR = 2.81; 95% CI: 1.1-7.01; p = 0.03), while no 
      difference was seen with the mammalian target of rapamycin (mTOR) inhibitors. Our 
      results confirm an influence of the individual immunosuppressive regimen, in 
      addition to the duration of immunosuppression, and suggest that older patients, 
      males, fair skinned recipients or those affected with high counts of actinic 
      keratoses (field cancerisation) are particularly prone to development of NMSC.
FAU - Kaufmann, Robin Adrian
AU  - Kaufmann RA
AD  - Department of Dermatology, Inselspital, University Hospital Bern, Freiburgstrasse 
      4, CH-3010 Bern, Switzerland.
FAU - Oberholzer, Patrick Antony
AU  - Oberholzer PA
AD  - Department of Dermatology, Inselspital, University Hospital Bern, Freiburgstrasse 
      4, CH-3010 Bern, Switzerland.
FAU - Cazzaniga, Simone
AU  - Cazzaniga S
AD  - Department of Dermatology, Inselspital, University Hospital Bern, Freiburgstrasse 
      4, CH-3010 Bern, Switzerland, Centro Studi GISED, Via Garibaldi 13/15, I-24122 
      Bergamo, Italy.
FAU - Hunger, Robert Emil
AU  - Hunger RE
AD  - Department of Dermatology, Inselspital, University Hospital Bern, Freiburgstrasse 
      4, CH-3010 Bern, Switzerland.
LA  - eng
PT  - Journal Article
PL  - France
TA  - Eur J Dermatol
JT  - European journal of dermatology : EJD
JID - 9206420
RN  - 0 (Calcineurin Inhibitors)
RN  - 0 (Immunosuppressive Agents)
RN  - 0 (Protein Kinase Inhibitors)
SB  - IM
MH  - Adult
MH  - Age Factors
MH  - Calcineurin Inhibitors/therapeutic use
MH  - Carcinoma, Basal Cell/*epidemiology
MH  - Carcinoma, Squamous Cell/*epidemiology
MH  - Female
MH  - Humans
MH  - Immunosuppression Therapy/*methods
MH  - Immunosuppressive Agents/*therapeutic use
MH  - Incidence
MH  - Keratosis, Actinic/epidemiology
MH  - *Kidney Transplantation
MH  - Longitudinal Studies
MH  - Male
MH  - Middle Aged
MH  - Protein Kinase Inhibitors/therapeutic use
MH  - Retrospective Studies
MH  - Risk Factors
MH  - Sex Factors
MH  - Skin Neoplasms/*epidemiology
MH  - Skin Pigmentation
OTO - NOTNLM
OT  - immunosuppression
OT  - kidney transplant recipients
OT  - non-melanoma skin cancer
EDAT- 2016/03/18 06:00
MHDA- 2017/06/24 06:00
CRDT- 2016/03/18 06:00
PHST- 2016/03/18 06:00 [entrez]
PHST- 2016/03/18 06:00 [pubmed]
PHST- 2017/06/24 06:00 [medline]
AID - ejd.2016.2758 [pii]
AID - 10.1684/ejd.2016.2758 [doi]
PST - ppublish
SO  - Eur J Dermatol. 2016 Jun 1;26(3):265-70. doi: 10.1684/ejd.2016.2758.