PMID- 26986105
OWN - NLM
STAT- MEDLINE
DCOM- 20160801
LR  - 20191210
IS  - 1536-5964 (Electronic)
IS  - 0025-7974 (Print)
IS  - 0025-7974 (Linking)
VI  - 95
IP  - 11
DP  - 2016 Mar
TI  - A Preoperative Nutritional Index for Predicting Cancer-Specific and Overall 
      Survival in Chinese Patients With Laryngeal Cancer: A Retrospective Study.
PG  - e2962
LID - 10.1097/MD.0000000000002962 [doi]
LID - e2962
AB  - Pinato prognostic nutritional index (PNI) adequately predicts long-term outcomes 
      of various malignancies. However, its value in predicting outcomes in laryngeal 
      squamous cell carcinoma (LSCC) is unknown. All patients newly diagnosed with LSCC 
      presenting to the Department of Head and Neck Oncology at Sun Yat-sen University 
      Cancer Center between January 1, 1990 and July 31, 2010 were eligible. The PNI 
      was calculated as serum albumin (g/L) + 5 x total lymphocyte count/L. The Cutoff 
      Finder software program was used to classify the patients into 3 groups for which 
      the PNI score was at least 70% sensitive, at least 70% specific, or equivocal. 
      Cancer-specific survival was estimated using the Kaplan-Meier method, and 
      predictors were assessed with Cox regression analysis. Median time between 
      surgery and PNI administration for the 975 eligible patients was 83 months. Index 
      score groups were significantly associated with age, T stage, TNM stage, and type 
      of surgery. Five-year CSS and OS were 57.3% and 56.6% in patients with PNI scores 
      below 48.65 (low-probability of survival), 72.8% and 71.3% with scores between 
      48.65 and 56.93 (moderate-probability of survival), and 77.6% and 75.3% with 
      scores above 56.93 (high-probability of survival); 10-year CSS and OS were 44.2% 
      and 42.7%, 61.6% and 55.6%, 68.3% and 63.5%, respectively. The PNI score groups 
      significantly predicted CSS and OS (P < 0.001). The PNI is an inexpensive and 
      readily available score that predicted survival in patients with LSCC after 
      curative laryngectomy.
FAU - Fu, Yan
AU  - Fu Y
AD  - From the Department of Head and Neck Oncology, Sun Yat-sen University Cancer 
      Center, State Key Laboratory of Oncology in South China, Collaborative Innovation 
      Center for Cancer Medicine, Guangzhou, Guangdong, People's Republic of China.
FAU - Chen, Shu-Wei
AU  - Chen SW
FAU - Chen, Shi-Qi
AU  - Chen SQ
FAU - Ou-Yang, Dian
AU  - Ou-Yang D
FAU - Liu, Wei-Wei
AU  - Liu WW
FAU - Song, Ming
AU  - Song M
FAU - Yang, An-Kui
AU  - Yang AK
FAU - Zhang, Quan
AU  - Zhang Q
LA  - eng
PT  - Journal Article
PT  - Observational Study
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Medicine (Baltimore)
JT  - Medicine
JID - 2985248R
SB  - IM
MH  - Age Factors
MH  - *Carcinoma, Squamous Cell/mortality/pathology/physiopathology/surgery
MH  - China/epidemiology
MH  - Female
MH  - Humans
MH  - Kaplan-Meier Estimate
MH  - *Laryngeal Neoplasms/mortality/pathology/physiopathology/surgery
MH  - Laryngectomy/*methods
MH  - Male
MH  - Neoplasm Staging
MH  - *Nutrition Assessment
MH  - Nutritional Status
MH  - Outcome Assessment, Health Care
MH  - Predictive Value of Tests
MH  - Preoperative Care/methods
MH  - Prognosis
MH  - Retrospective Studies
MH  - Survival Analysis
PMC - PMC4839886
COIS- The authors have no conflicts of interest to disclose.
EDAT- 2016/03/18 06:00
MHDA- 2016/08/02 06:00
PMCR- 2016/03/18
CRDT- 2016/03/18 06:00
PHST- 2016/03/18 06:00 [entrez]
PHST- 2016/03/18 06:00 [pubmed]
PHST- 2016/08/02 06:00 [medline]
PHST- 2016/03/18 00:00 [pmc-release]
AID - 00005792-201603150-00012 [pii]
AID - 10.1097/MD.0000000000002962 [doi]
PST - ppublish
SO  - Medicine (Baltimore). 2016 Mar;95(11):e2962. doi: 10.1097/MD.0000000000002962.