PMID- 26989058
OWN - NLM
STAT- MEDLINE
DCOM- 20171130
LR  - 20181202
IS  - 1708-0428 (Electronic)
IS  - 0960-8923 (Linking)
VI  - 26
IP  - 10
DP  - 2016 Oct
TI  - Serum Leptin and Adiponectin Concentration in Type 2 Diabetes Patients in the 
      Short and Long Term Following Biliopancreatic Diversion.
PG  - 2442-8
LID - 10.1007/s11695-016-2126-z [doi]
AB  - BACKGROUND: A deranged adipokine system is implicated in obesity and in type 2 
      diabetes mellitus (T2DM), and the lack of remission of T2DM after bariatric 
      surgery could be also accounted for by the postoperative persistence of this 
      condition. METHODS: Thirty T2DM patients undergoing biliopancreatic diversion 
      (BPD) with a wide range of baseline body mass index (BMI) were evaluated prior to 
      and at 1 and 5 years following BPD. Besides the usual clinical evaluations, acute 
      insulin response (AIR) to intravenous glucose load as a parameter of insulin 
      secretion and the serum leptin and adiponectin concentration were measured 
      throughout the follow-up period in all patients. RESULTS: A long-term T2DM 
      remission was observed in 21 patients (70 %). Serum leptin level reduced at the 
      first year and remained substantially unchanged at a long term in both the 
      remitter and non-remitter patients, while following the operation, a progressive 
      significant increase of serum adiponectin level was observed only in remitter 
      patients (from 9.2 to 12.3 mug/mL at 1 year and to 15.18 mug/mL at 5 years in the 
      remitters and from 8.8 to 8.75 mug/mL at 1 year and to 11.8 mug/mL at 5 years in 
      the non-remitters). Serum leptin mean values were positively associated with the 
      BMI ones both prior to and following BPD (p < 0.005), while serum adiponectin 
      values were positively related (p < 0.04) to the postoperative AIR data. 
      CONCLUSIONS: The improvement of the pattern of cytokine production, as evidenced 
      by postoperative rise in serum adiponectin concentration, might play a role in 
      T2DM remission after bariatric surgery.
FAU - Adami, Gian Franco
AU  - Adami GF
AD  - Department of Internal Medicine, University of Genova, Azienda Ospedaliera 
      Universitaria San Martino, Largo Benzi 8, 16132, Genova, Italy. adami@unige.it.
FAU - Gradaschi, Raffaella
AU  - Gradaschi R
AD  - Department of Clinical Nutrition, University of Genova, Azienda Ospedaliera 
      Universitaria San Martino, Genova, Italy.
FAU - Andraghetti, Gabriella
AU  - Andraghetti G
AD  - Department of Internal Medicine, University of Genova, Azienda Ospedaliera 
      Universitaria San Martino, Largo Benzi 8, 16132, Genova, Italy.
FAU - Scopinaro, Nicola
AU  - Scopinaro N
AD  - Department of Surgery, University of Genova, Azienda Ospedaliera Universitaria 
      San Martino, Genova, Italy.
FAU - Cordera, Renzo
AU  - Cordera R
AD  - Department of Internal Medicine, University of Genova, Azienda Ospedaliera 
      Universitaria San Martino, Largo Benzi 8, 16132, Genova, Italy.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Obes Surg
JT  - Obesity surgery
JID - 9106714
RN  - 0 (ADIPOQ protein, human)
RN  - 0 (Adiponectin)
RN  - 0 (Leptin)
SB  - IM
MH  - Adiponectin/*blood
MH  - Adult
MH  - Aged
MH  - *Biliopancreatic Diversion
MH  - Diabetes Mellitus, Type 2/*blood/*surgery
MH  - Female
MH  - Humans
MH  - Insulin Resistance
MH  - Leptin/*blood
MH  - Male
MH  - Middle Aged
MH  - Obesity/*blood/surgery
MH  - Postoperative Period
MH  - Time Factors
OTO - NOTNLM
OT  - Acute insulin response
OT  - Adiponectin
OT  - Bariatric surgery
OT  - Leptin
OT  - Type 2 diabetes
EDAT- 2016/03/19 06:00
MHDA- 2017/12/01 06:00
CRDT- 2016/03/19 06:00
PHST- 2016/03/19 06:00 [entrez]
PHST- 2016/03/19 06:00 [pubmed]
PHST- 2017/12/01 06:00 [medline]
AID - 10.1007/s11695-016-2126-z [pii]
AID - 10.1007/s11695-016-2126-z [doi]
PST - ppublish
SO  - Obes Surg. 2016 Oct;26(10):2442-8. doi: 10.1007/s11695-016-2126-z.