PMID- 2698967
OWN - NLM
STAT- MEDLINE
DCOM- 19900515
LR  - 20190828
IS  - 0021-521X (Print)
IS  - 0021-521X (Linking)
VI  - 39
IP  - 6
DP  - 1989
TI  - Complicated central effects of endothelin on blood pressure in rats.
PG  - 825-32
AB  - The role of endothelin (ENT) in the control of systemic blood pressure (BP) was 
      examined in conscious rats. Intracerebroventricular (i.c.v.) administration of 
      ENT (0.002 or 0.2 micrograms, i.e., 0.78 or 78 pmol/2 microliters 0.9% saline) to 
      conscious rats had complicated effects on BP. A significant fall in BP occurred 
      in the initial 2-4 min after administration; and then after recovery toward the 
      control level, BP decreased again within 17 min, following which a constant rise 
      in BP occurred. In addition to the changes in BP, 3 of 9 rats which received 0.2 
      micrograms lapsed into severe barrel rotation-like behavior only to die 6-8 min 
      after i.c.v. injection. It was therefore assumed that ENT had central effects on 
      BP regulation and motor activity.
FAU - Minamisawa, K
AU  - Minamisawa K
AD  - Department of Internal Medicine, Yokohama City University School of Medicine, 
      Japan.
FAU - Hashimoto, R
AU  - Hashimoto R
FAU - Ishii, M
AU  - Ishii M
FAU - Kimura, F
AU  - Kimura F
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Japan
TA  - Jpn J Physiol
JT  - The Japanese journal of physiology
JID - 2985184R
RN  - 0 (Endothelins)
RN  - 0 (Peptides)
SB  - IM
MH  - Animals
MH  - Blood Pressure/*drug effects/physiology
MH  - Endothelins
MH  - Hypotension/chemically induced
MH  - Injections, Intraventricular
MH  - Male
MH  - Peptides/administration & dosage/*pharmacology
MH  - Rats
MH  - Rats, Inbred Strains
MH  - Time Factors
EDAT- 1989/01/01 00:00
MHDA- 1989/01/01 00:01
CRDT- 1989/01/01 00:00
PHST- 1989/01/01 00:00 [pubmed]
PHST- 1989/01/01 00:01 [medline]
PHST- 1989/01/01 00:00 [entrez]
AID - 10.2170/jjphysiol.39.825 [doi]
PST - ppublish
SO  - Jpn J Physiol. 1989;39(6):825-32. doi: 10.2170/jjphysiol.39.825.